Impact of oral amoxicillin and amoxicillin/clavulanic acid treatment on bacterial diversity and β-lactam resistance in the canine faecal microbiota

Autor: Luca Guardabassi, Jean de Gunzburg, Teresa Pires dos Santos, Perrine Hugon, Agathe Nevière, Sakina Sayah-Jeanne, Frédérique Sablier-Gallis, Carmen Espinosa-Gongora, Lisbeth Rem Jessen, Charlotte R. Bjornvad, Peter Damborg, Dereje Dadi Gudeta, Nathalie Saint-Lu, Tanguy Corbel, Ida N. Kieler

Publikováno v: The Journal of antimicrobial chemotherapy. 75(2)

Background Aminopenicillins with or without a β-lactamase inhibitor are widely used in both human and veterinary medicine. However, little is known about their differential impact on the gut microbiota and development of antimicrobial resistance. Ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2626323873d157c73a6957316d64a38
https://pubmed.ncbi.nlm.nih.gov/31778166

Chromobacteriumspp. harbour Ambler class A β-lactamases showing high identity with KPC

Autor: Laurent Poirel, Aurélie Jayol, Luca Guardabassi, Dereje Dadi Gudeta, Valeria Bortolaia, Patrice Nordmann

Publikováno v: Journal of Antimicrobial Chemotherapy. 71:1493-1496

Objectives The origin of KPC is unknown. The aim of this study was to detect progenitors of KPC in silico and to functionally verify their β-lactam hydrolysis activity. Methods The sequence of KPC-2 was used to mine the NCBI protein sequence databas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af861b4914049adc9bdef212e262ecb0
https://doi.org/10.1093/jac/dkw020

Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota

Autor: Elizabeth M. H. Wellington, Jean Denis Docquier, Dereje Dadi Gudeta, Simona Pollini, Gregory C. A. Amos, Valeria Bortolaia, Luca Guardabassi, Gian Maria Rossolini

Publikováno v: Gudeta, D D, Bortolaia, V, Pollini, S, Docquier, J-D, Rossolini, G M, Amos, G C A, Wellington, E M H & Guardabassi, L 2016, ' Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ss-Lactamases by Functional Metagenomic Analysis of Soil Microbiota ', Frontiers in Microbiology, vol. 7, 1985 . https://doi.org/10.3389/fmicb.2016.01985
Gudeta, D D, Bortolaia, V, Pollini, S, Docquier, J-D, Rossolini, G M, Amos, G C A, Wellington, E M H & Guardabassi, L 2016, ' Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota ', Frontiers in Microbiology, vol. 7, 1985 . https://doi.org/10.3389/fmicb.2016.01985
Frontiers in Microbiology

Carbapenemases are bacterial enzymes that hydrolyze carbapenems, a group of last-resort ss-lactam antibiotics used for treatment of severe bacterial infections. They belong to three beta-lactamase classes based amino acid sequence (A, B, and D). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f14069fef2bfee85d10f19c711f6b2

New Insights into Staphylococcus aureus Stress Tolerance and Virulence Regulation from an Analysis of the Role of the ClpP Protease in the Strains Newman, COL, and SA564

Autor: Antti Sukura, Kerttu Koskenniemi, Julie H. Andersen, Kirsi Savijoki, Dereje Dadi Gudeta, Dorte Frees, Lene Hemmingsen, Pekka Varmanen, Tuula A. Nyman, Musemma K. Muhammed, Kristoffer T. Bæk

Publikováno v: Journal of Proteome Research. 11:95-108

In Staphylococcus aureus, ClpP proteases were previously shown to be essential for virulence and stress tolerance in strains derived from NCTC8325. Because these strains exhibit a severely reduced activity of the alternative sigma factor, SigB, we he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f48c0a0552dc6576ecbd75fd8964810
https://doi.org/10.1021/pr200956s

New Insights into Staphylococcus aureusStress Tolerance and Virulence Regulation from an Analysis of the Role of the ClpP Protease in the Strains Newman, COL, and SA564.

Autor: Dorte Frees, Julie Hove Andersen, Lene Hemmingsen, Kerttu Koskenniemi, Kristoffer T. Bæk, Musemma Kedir Muhammed, Dereje Dadi Gudeta, Tuula A. Nyman, Antti Sukura, Pekka Varmanen, Kirsi Savijoki

Publikováno v: Journal of Proteome Research; Jan2012, Vol. 11 Issue 1, p95-108, 14p