Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalization via macropinocytosis.

Autor: Derby SJ; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Dutton L; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Strathdee KE; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Stevenson K; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Koessinger A; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK.; CRUK Scotland Institute, Glasgow, UK., Jackson M; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Tian Y; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Yu W; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Mclay K; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Misquitta J; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Alsharif S; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Clarke CJ; CRUK Scotland Institute, Glasgow, UK., Gilmour L; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Thomason P; CRUK Scotland Institute, Glasgow, UK., McGhee E; CRUK Scotland Institute, Glasgow, UK., McGarrity-Cottrell CL; Department of Oncology and Metabolism, The University of Sheffield Medical School, Sheffield, UK., Vanderlinden A; Department of Oncology and Metabolism, The University of Sheffield Medical School, Sheffield, UK., Collis SJ; Department of Oncology and Metabolism, The University of Sheffield Medical School, Sheffield, UK., Rominyi O; Department of Oncology and Metabolism, The University of Sheffield Medical School, Sheffield, UK., Lemgruber L; Cellular Analysis Facility, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK., Solecki G; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Olson M; Department of Chemistry and Biology, Ryeson University, Toronto, Ontario, Canada., Winkler F; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Carlin LM; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK.; CRUK Scotland Institute, Glasgow, UK., Heiland DH; MILO Laboratory, Department of Neurosurgery, Freiburg, Germany., Inman GJ; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK.; CRUK Scotland Institute, Glasgow, UK., Chalmers AJ; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Norman JC; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK.; CRUK Scotland Institute, Glasgow, UK., Carruthers R; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Birch JL; Wolfson Wohl Translational Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK.

Publikováno v: Neuro-oncology [Neuro Oncol] 2024 Apr 05; Vol. 26 (4), pp. 625-639.