Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Der-I Kao"'
Autor:
Zaniar Ghazizadeh, Der-I Kao, Sadaf Amin, Brandoch Cook, Sahana Rao, Ting Zhou, Tuo Zhang, Zhaoying Xiang, Reyn Kenyon, Omer Kaymakcalan, Chengyang Liu, Todd Evans, Shuibing Chen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Our incomplete understanding of how pancreatic beta cells form limits the generation of beta-like cells from human pluripotent stem cells (hPSC). Here, the authors identify a ROCKII inhibitor H1152 as increasing insulin secreting cells from hPSCs and
Externí odkaz:
https://doaj.org/article/aa6907d977454e5fb768c8afd2a10055
Autor:
Der-I Kao, Lauretta A. Lacko, Bi-Sen Ding, Chen Huang, Kathleen Phung, Guoqiang Gu, Shahin Rafii, Heidi Stuhlmann, Shuibing Chen
Publikováno v:
Stem Cell Reports, Vol 4, Iss 2, Pp 181-189 (2015)
Although endothelial cells have been shown to affect mouse pancreatic development, their precise function in human development remains unclear. Using a coculture system containing human embryonic stem cell (hESC)-derived progenitors and endothelial c
Externí odkaz:
https://doaj.org/article/e6d601d233eb4aff9d1439b111013bc4
Autor:
Moumita Das, Der-I Kao, Yehudah Pardo, Minglin Ma, Yen-Chun Lu, Shuibing Chen, Wei Song, Chih-kuan Tung, Mingming Wu
Publikováno v:
Soft Matter. 12:5739-5746
Cells with different cohesive properties self-assemble in a spatiotemporal and context-dependent manner. Previous studies on cell self-organization mainly focused on the spontaneous structural development within a short period of time during which th
Autor:
Ting Zhou, Chengyang Liu, Brandoch D. Cook, Todd Evans, Omer Kaymakcalan, Shuibing Chen, Zhaoying Xiang, Zaniar Ghazizadeh, Tuo Zhang, Sahana D. Rao, Sadaf Amin, Der-I Kao, Reyn Kenyon
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Diabetes is linked to loss of pancreatic beta-cells. Pluripotent stem cells offer a valuable source of human beta-cells for basic studies of their biology and translational applications. However, the signalling pathways that regulate beta-cell develo
Publikováno v:
ACS Applied Materials & Interfaces
A simple, robust, and cost-effective method is developed to fabricate nanofibrous micropatterns particularly microposts and microwells of controlled shapes. The key to this method is the use of an easily micropatternable and intrinsically conductive
Publikováno v:
Proceedings of the National Academy of Sciences. 107:15601-15606
Fragile X syndrome is caused by the absence of functional fragile X mental retardation protein (FMRP), an RNA binding protein. The molecular mechanism of aberrant protein synthesis in fmr1 KO mice is closely associated with the role of FMRP in mRNA t
Publikováno v:
Science. 302:279-282
During spliceosome activation, a large structural rearrangement occurs that involves the release of two small nuclear RNAs, U1 and U4, and the addition of a protein complex associated with Prp19p. We show here that the Prp19p-associated complex is re
Publikováno v:
Molecular and cellular biology. 34(2)
The yeast Sad1 protein was previously identified in a screen for factors involved in the assembly of the U4/U6 di-snRNP particle. Sad1 is required for pre-mRNA splicing both in vivo and in vitro, and its human orthologue has been shown to associate w
Autor:
Shuibing Chen, Der-I Kao
Publikováno v:
Stem Cells Handbook ISBN: 9781461476955
Diabetes mellitus, which affects 346 million people, is one of the leading causes of death worldwide. Pancreatic β cells play a central role in the progression of diabetes. In addition, pancreas or islet transplantation has been used to treat type 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75ca624caacd62f3580b06a23e59389e
https://doi.org/10.1007/978-1-4614-7696-2_30
https://doi.org/10.1007/978-1-4614-7696-2_30
Autor:
Shuibing Chen, Der-I Kao
Publikováno v:
Regenerative medicine. 7(4)
Diabetes mellitus, which affects 346 million people, is one of the leading causes of death worldwide. Pancreatic β-cells, existing in the islets of Langerhans, play central roles in the progression of diabetes. An efficient strategy to produce funct