Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Deping Chai"'
Autor:
Nannan Liu, Michael N. Zimmerman, Richard M. Keenan, Victor K. Johnston, Deping Chai, Rosanna Tedesco, Duke M. Fitch, Juili Lin-Goerke, Kenneth Wiggall, Antony N. Shaw, Nestor O. Concha, Ramesh Bambal, Michael G. Darcy, Robert T. Sarisky, Dashyant Dhanak, Kevin J. Duffy, Adam T. Gates
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4350-4353
The synthesis and optimisation of HCV NS5B polymerase inhibitors with improved potency versus the existing compound 1 is described. Substitution in the benzothiadiazine portion of the molecule, furnishing improvement in potency in the high protein Re
Autor:
George Burton, Karen A. Evans, Ralph A. Rivero, Deping Chai, Robert T. Sarisky, Juili Lin-Goerke, Todd L. Graybill, Victor K. Johnston
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2205-2208
An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids is reported. Starting from commercially available chiral Fmoc-protected alpha-amino acids loaded onto Wang resin, Fmoc removal, reductive amination followed
Autor:
Chao Han, Warren W. Gerhardt, Dashyant Dhanak, Kevin J. Duffy, Nestor O. Concha, Adam T. Gates, Richard M. Keenan, Victor K. Johnston, Glenn A. Hofmann, Duke M. Fitch, Nannan Liu, Kenneth Wiggall, Antony N. Shaw, Dina L. Halegoua, Robert T. Sarisky, Michael N. Zimmerman, Ramesh Bambal, Michael G. Darcy, Arun C. Kaura, Juili Lin-Goerke, Deping Chai, Rosanna Tedesco
Publikováno v:
Journal of Medicinal Chemistry. 49:971-983
Recently, we disclosed a new class of HCV polymerase inhibitors discovered through high-throughput screening (HTS) of the GlaxoSmithKline proprietary compound collection. This interesting class of 3-(1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy
Publikováno v:
Tetrahedron. 59:3183-3188
The aglycone of 26-O-deacetyl pavoninin-5, (25R)-cholest-5-en-3β,15α,26-triol, 5a , was synthesized in 10 steps in 17% overall yield from diosgenin, 3 . Removing mercury from the Clemmensen reduction of diosgenin 3 , gave a higher yield of (25R)-ch
Publikováno v:
Steroids. 67:1041-1044
We describe the synthesis of (25R)-cholest-5-en-3beta,26-diol ((25R)-26-hydroxycholesterol) from diosgenin in four steps in 58% overall, yield via a modified Clemmensen reduction followed by a Barton deoxygenation reaction.
Autor:
Duke M. Fitch, Stephen Schauer, Steven D. Knight, Zhengping Wang, Michael N. Zimmerman, Kurt R. Auger, Roman Sakowicz, Dashyant Dhanak, Han-Jie Zhou, Amita M. Chaudhari, Carrie E. Aroyan, Jeffrey T. Finer, Deping Chai, Jeffrey R. Jackson, Lance Ridgers, Luke W. Ashcraft, Seyed Ahmed, Kenneth Wood, Erin D. Hugger, Jennifer Kuo Chen Huang, Melchor V. Marin, John D. Elliott, Andrew Mcdonald, Cynthia A. Parrish, David Sutton, Ramesh Baliga, Mariela Colón, Lisa D. Belmont, Carla A. Donatelli, Nicholas D. Adams, Joelle Lorraine Burgess, Hong Jiang, Rosanna Tedesco, Bing Yao, Jianchao Wang, Kevin J. Duffy, Gustave Bergnes, Xiangping Qian, Chiu-Mei Sung, David J. Morgans, Robert A. Copeland, Bradley P. Morgan, Michael G. Darcy, Jeffrey D. Carson, Latesh Lad, Ken A. Newlander, Lusong Luo, Daniel W. Pierce, Schmidt Stanley J
Publikováno v:
ACS medicinal chemistry letters. 1(1)
Inhibition of mitotic kinesins represents a novel approach for the discovery of a new generation of anti-mitotic cancer chemotherapeutics. We report here the discovery of the first potent and selective inhibitor of centromere-associated protein E (CE
Autor:
Rosanna Tedesco, Duke M. Fitch, Robert T. Sarisky, Antony N. Shaw, Michael N. Zimmerman, Kevin J. Duffy, Michael G. Darcy, Dashyant Dhanak, Juili Lin-Goerke, Richard M. Keenan, Adam T. Gates, Victor K. Johnston, Deping Chai, Kenneth Wiggall, Klára Valkó
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
Modification of the benzo rings of 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones into heteroaromatic systems was investigated to enhance physicochemical properties and potency profile of this class of inhibitors. The synt
Publikováno v:
Lipids. 37(12)
Sharks are the most dangerous predators of people in the sea, resulting in people being mauled and killed each year. A shark repellent could help to diminish this danger. The aglycone of the shark repellent pavoninin-5, (25R)-cholest-5-en-3beta,15alp
Autor:
Richard Wooster, Kristin K. Brown, Deping Chai, Mariela Colón, Jennifer L. Ariazi, Chad Quinn, Sharon Sweitzer, Nino Campobasso, Subhas J. Chakravorty, Gregory M. Waitt, Tony Shaw, Kevin J. Duffy, Roland S. Annan, Jacques Briand, Nathan Gaul, Christian S. Sherk, Elizabeth A. Davenport, Jeanelle McSurdy-Freed, Kelvin Nurse, Anthony J. Jurewicz, Dean E. McNulty, Gilbert F. Scott, Angela Smallwood, James P. Villa, Hong Lu, Paru Nuthulaganti, Julia Billiard, Christopher S Dodson, Jessica L. Schneck, Lisa Miller, Seth A. Gilbert
Publikováno v:
Cancer Research. 73:5418-5418
Many cancer cells generate energy by rapidly converting glucose to lactate in the cytosol, a process termed aerobic glycolysis. This metabolic phenotype is recognized as one of the hallmarks of cancer and is enabled by lactate dehydrogenase (LDH), wh
Autor:
Joel Greshock, Mariela Colón, Chad Quinn, Gilbert F. Scott, Gordon B. Mills, Richard Wooster, Gregory M. Waitt, Shaw Antony N, Roland S. Annan, Junping Jing, Kevin J. Duffy, Lisa A. Orband-Miller, Jacques Briand, Hong Lu, Julia Billiard, Seth A. Gilbert, Jeanelle McSurdy-Freed, Christopher S Dodson, Jessica L. Schneck, Jennifer B. Dennison, Deping Chai
Publikováno v:
Cancer & Metabolism
Background Most normal cells in the presence of oxygen utilize glucose for mitochondrial oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in the cytosol, a process termed aerobic glycolysis. This glycolytic