Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease

Autor: Eleanor Sinclair, Drupad K. Trivedi, Depanjan Sarkar, Caitlin Walton-Doyle, Joy Milne, Tilo Kunath, Anouk M. Rijs, Rob M. A. de Bie, Royston Goodacre, Monty Silverdale, Perdita Barran

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Studies of metabolites in neurodegeneration have not yet used sebum as a source fluid. Here the authors demonstrate the potential of metabolomics of sebum samples from individuals with Parkinson’s disease and controls.

Externí odkaz: https://doaj.org/article/9e01bc89a95e413fbdff0e9ee7e5a51b

Discovery of Volatile Biomarkers of Parkinson’s Disease from Sebum

Autor: Drupad K. Trivedi, Eleanor Sinclair, Yun Xu, Depanjan Sarkar, Caitlin Walton-Doyle, Camilla Liscio, Phine Banks, Joy Milne, Monty Silverdale, Tilo Kunath, Royston Goodacre, Perdita Barran

Publikováno v: ACS Central Science, Vol 5, Iss 4, Pp 599-606 (2019)

Externí odkaz: https://doaj.org/article/9b8c5bb9324f4f0bbc1a10b863534966

Paper Spray Ionization Ion Mobility Mass Spectrometry of Sebum Classifies Biomarker Classes for the Diagnosis of Parkinson's Disease

Autor: Monty Silverdale, Kaneez Jafri, Johannes P. C. Vissers, Keith Richardson, Caitlin Walton-Doyle, Eleanor Sinclair, Perdita E. Barran, Joy Milne, Sze Hway Lim, Depanjan Sarkar, Drupad Trivedi

Publikováno v: Sarkar, D, Sinclair, E, Lim, S H, Walton-Doyle, C, Jafri, K, Milne, J, Vissers, J P C, Richardson, K, Trivedi, D K, Silverdale, M & Barran, P 2022, ' Paper Spray Ionization Ion Mobility Mass Spectrometry of Sebum Classifies Biomarker Classes for the Diagnosis of Parkinson's Disease ', JACS Au, vol. 2, no. 9, pp. 2013-2022 . https://doi.org/10.1021/jacsau.2c00300

Parkinson’s disease (PD) is the second most common neurodegenerative disorder and identification of robust biomarkers to complement clinical diagnosis will accelerate treatment options. Here we demonstrate the use of direct infusion of sebum from s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e3b6cf5ff13c330462125e2e854d18
http://www.scopus.com/inward/record.url?scp=85139221703&partnerID=8YFLogxK

Validating differential volatilome profiles in Parkinson’s disease

Autor: Monty Silverdale, Tilo Kunath, Joy Milne, Rob M.A. de Bie, Sze Hway Lim, Anouk M. Rijs, Depanjan Sarkar, Drupad K. Trivedi, Caitlin Walton-Doyle, Katherine A. Hollywood, Perdita E. Barran, Eleanor Sinclair

Publikováno v: Sinclair, E, Walton-Doyle, C, Sarkar, D, Hollywood, K A, Milne, J, Lim, S H, Kunath, T, Rijs, A M, De Bie, R M A, Silverdale, M, Trivedi, D K & Barran, P 2021, ' Validating differential volatilome profiles in Parkinson’s disease ', ACS Central Science, vol. 7, no. 2, pp. 300-306 . https://doi.org/10.1021/acscentsci.0c01028
ACS central science, 7(2), 300-306. American Chemical Society
Acs Central Science, 7, 2, pp. 300-306
Sinclair, E, Walton-Doyle, C, Sarkar, D, Hollywood, K A, Milne, J, Lim, S H, Kunath, T, Rijs, A M, de Bie, R M A, Silverdale, M, Trivedi, D K & Barran, P 2021, ' Validating differential volatilome profiles in Parkinson's disease ', ACS Central Science, vol. 7, no. 2, pp. 300-306 . https://doi.org/10.1021/acscentsci.0c01028
ACS Central Science, Vol 7, Iss 2, Pp 300-306 (2021)
ACS Central Science, 7(2), 300-306. American Chemical Society
Acs Central Science, 7, 300-306
ACS Central Science

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that does not currently have a robust clinical diagnostic test. Nonmotor symptoms such as skin disorders have long since been associated with the disease, and more recently a char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0056f993f29c76e87d8044d8ded1d042
https://www.pure.ed.ac.uk/ws/files/199336730/acscentsci.0c01028.pdf

Sebum: a window into dysregulation of lipid metabolism in Parkinson’s disease

Autor: Eleanor Sinclair, Drupad Trivedi, Depanjan Sarkar, Caitlin Walton-Doyle, Joy Milne, Tilo Kunath, Anouk Rijs, Rob Debie, Royston Goodacre, Monty Silverdale, Perdita Barran

A metabolomics profiling approach was conducted to identify diagnostic biomarkers of PD from sebum, a non-invasively available biofluid. In this study, we used liquid chromatography-mass spectrometry (LC-MS) to analyse 274 samples from participants (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67244730e4f5ed3bfb4023bce01e7c02
https://doi.org/10.26434/chemrxiv.11603613