Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Deon Doree"'
Autor:
Christopher M. DaCosta, Robert Brommage, Isaac Van Sligtenhorst, Zhi-Ming Ding, Gwenn M. Hansen, Kenneth A. Platt, Jean-Pierre Revelli, Deon Doree, David R. Powell
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:2641-2652
Purpose In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 (PRKD1) and G2/M-phase-specific E3 ubiquitin protein ligase (G2E3) genes on chromosome 14 are associated with obesity. To date, no published evidence links
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1241da8071ecf353792b00269b89ba
https://doi.org/10.2147/dmso.s259546
https://doi.org/10.2147/dmso.s259546
Autor:
Qingyun Liu, Sabrina Jeter-Jones, Dawn Bright, Sofia Movérare-Skrtic, Peter Vogel, Jeff Liu, David Potter, Arthur T. Sands, Faika Mseeh, Petra Henning, Ulf H. Lerner, Robert Brommage, David R. Powell, Karin H Nilsson, James E. Tarver, Claes Ohlsson, Andrea Y. Thompson, Gwenn M. Hansen, Jennifer Bardenhagen, Brian Zambrowicz, Melanie K. Shadoan, Jie Cui, Deon Doree
Publikováno v:
Bone Research, Vol 7, Iss 1, Pp 1-12 (2019)
Bone Research
Bone Research
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major determinant of non-v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86097837810f29eb2b4926f9c7eafee1
http://link.springer.com/article/10.1038/s41413-018-0038-3
http://link.springer.com/article/10.1038/s41413-018-0038-3
Autor:
Alan Wilson, Angela L. Harris, Brian Zambrowicz, Wendy Xiong, Christopher M. DaCosta, David R. Powell, Bryce Alden Harrison, Nicole Cathleen Goodwin, Melinda Smith, Sabrina Jeter-Jones, Andrea Y. Thompson, Eric Strobel, Faika Mseeh, David B. Rawlins, Jennifer Greer, Deon Doree, Suma Gopinathan, Kenneth G. Carson, Zhi-Ming Ding
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(1)
LX2761 is a potent sodium/glucose cotransporter 1 inhibitor restricted to the intestinal lumen after oral administration. Studies presented here evaluated the effect of orally administered LX2761 on glycemic control in preclinical models. In healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38140540d80f7939267c966c2d73c1da
https://pubmed.ncbi.nlm.nih.gov/28442582
https://pubmed.ncbi.nlm.nih.gov/28442582
KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation
Autor:
Laura R, Pearce, Neli, Atanassova, Matthew C, Banton, Bill, Bottomley, Agatha A, van der Klaauw, Jean-Pierre, Revelli, Audrey, Hendricks, Julia M, Keogh, Elana, Henning, Deon, Doree, Sabrina, Jeter-Jones, Sumedha, Garg, Elena G, Bochukova, Rebecca, Bounds, Sofie, Ashford, Emma, Gayton, Peter C, Hindmarsh, Julian P H, Shield, Elizabeth, Crowne, David, Barford, Nick J, Wareham, Stephen, O'Rahilly, Michael P, Murphy, David R, Powell, Ines, Barroso, I Sadaf, Farooqi
Publikováno v:
Cell; Vol 155
Cell
Cell
SummaryKinase suppressor of Ras 2 (KSR2) is an intracellular scaffolding protein involved in multiple signaling pathways. Targeted deletion of Ksr2 leads to obesity in mice, suggesting a role in energy homeostasis. We explored the role of KSR2 in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e45b3961f4e92b44d6aed8e0e31ce84a
Publikováno v:
BoneKEy Reports. 4
Disruption of serotonin synthesis in neurons and the periphery by knockout (KO) of mouse genes for tryptophan hydroxylases (peripheral Tph1 and neuronal Tph2) has been claimed to decrease (Tph2 KO) and increase (Tph1 KO) bone mass. In this report, ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f2322e0f3d2d28971e60c385c33a39
https://doi.org/10.1038/bonekey.2015.87
https://doi.org/10.1038/bonekey.2015.87
Autor:
David R. Powell, Jason P. Gay, Nathaniel Wilganowski, Deon Doree, Katerina V. Savelieva, Thomas H. Lanthorn, Robert Read, Peter Vogel, Gwenn M. Hansen, Robert Brommage, Zhi-Ming Ding, Urvi Desai, Brian Zambrowicz
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 6 (2015)
Frontiers in Endocrinology, Vol 6 (2015)
After creating >4650 knockouts (KOs) of independent mouse genes, we screened them by high-throughput phenotyping and found that cannabinoid receptor 1 (Cnr1) KO mice had the same lean phenotype published by others. We asked if our KOs of DAG lipase a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ae62f027be40916dd6ca5a591e419a
http://europepmc.org/articles/PMC4451644
http://europepmc.org/articles/PMC4451644
Autor:
David R. Powell, Arthur T. Sands, Zhi-Ming Ding, Sabrina Jeter-Jones, Brian Zambrowicz, Deon Doree
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
David R Powell, Deon Doree, Sabrina Jeter-Jones, Zhi-Ming Ding, Brian Zambrowicz, Arthur Sands Lexicon Pharmaceuticals, The Woodlands, TX, USA Purpose: Oral agents are needed that improve glycemic control without increasing hypoglycemic events in pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed186d817c2cbf048e78ca0d551ad03
https://www.dovepress.com/sotagliflozin-improves-glycemic-control-in-nonobese-diabetes-prone-mic-peer-reviewed-article-DMSO
https://www.dovepress.com/sotagliflozin-improves-glycemic-control-in-nonobese-diabetes-prone-mic-peer-reviewed-article-DMSO