Výsledky vyhledávání - "Deon B Doxie"

Akademický článek

HLA-DR cancer cells expression correlates with T cell infiltration and is enriched in lung adenocarcinoma with indolent behavior

Autor: Maria-Fernanda Senosain, Yong Zou, Tatiana Novitskaya, Georgii Vasiukov, Aneri B. Balar, Dianna J. Rowe, Deon B. Doxie, Jonathan M. Lehman, Rosana Eisenberg, Fabien Maldonado, Andries Zijlstra, Sergey V. Novitskiy, Jonathan M. Irish, Pierre P. Massion

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Lung adenocarcinoma (ADC) is a heterogeneous group of tumors associated with different survival rates, even when detected at an early stage. Here, we aim to investigate whether CyTOF identifies cellular and molecular predictors of tumor beha

Externí odkaz: https://doaj.org/article/6ab4fbb7ed444b2689b6cdcf1d62bde2

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Akademický článek

Risk-associated alterations in marrow T cells in pediatric leukemia

Autor: Jithendra Kini Bailur, Samuel S. McCachren, Katherine Pendleton, Juan C. Vasquez, Hong Seo Lim, Alyssa Duffy, Deon B. Doxie, Akhilesh Kaushal, Connor Foster, Deborah DeRyckere, Sharon Castellino, Melissa L. Kemp, Peng Qiu, Madhav V. Dhodapkar, Kavita M. Dhodapkar

Publikováno v: JCI Insight, Vol 5, Iss 16 (2020)

Current management of childhood leukemia is tailored based on disease risk determined by clinical features at presentation. Whether properties of the host immune response impact disease risk and outcome is not known. Here, we combine mass cytometry,

Externí odkaz: https://doaj.org/article/0fb79d513f1749a48537c85234f76e59

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Akademický článek

Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

Immunotherapy is used to treat melanoma, however patient responses vary widely highlighting the need for factors that can predict therapeutic success. Here, the authors show that MHC-II molecules expressed by tumour cells are positively correlated wi

Externí odkaz: https://doaj.org/article/459810ce61c5459985557e37a55f8eed

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HLA-DR cancer cells expression correlates with T cell infiltration and is enriched in lung adenocarcinoma with indolent behavior

Autor: Fabien Maldonado, Tatiana Novitskaya, Maria-Fernanda Senosain, Pierre P. Massion, Dianna J. Rowe, Georgii Vasiukov, Jonathan M. Irish, Deon B. Doxie, Andries Zijlstra, Sergey V. Novitskiy, Yong Zou, Aneri B. Balar, Jonathan M. Lehman, Rosana Eisenberg

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports

Lung adenocarcinoma (ADC) is a heterogeneous group of tumors associated with different survival rates, even when detected at an early stage. Here, we aim to investigate whether CyTOF identifies cellular and molecular predictors of tumor behavior. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864fdddacc4fcf1d7a556ec12986f089
https://doaj.org/article/6ab4fbb7ed444b2689b6cdcf1d62bde2

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Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types

Autor: Kirsten E. Diggins, Jonathan M. Irish, Megan L. Rasmussen, Deon B. Doxie, Allison R. Greenplate, P. Brent Ferrell, Peter J. Siska, Daniel D. McClanahan, Vivian Gama, Mark C. Kelley, Douglas B. Johnson, Caroline E. Roe, Jeffrey C. Rathmell, Nalin Leelatian, Brian K Oberholtzer

Publikováno v: Cancer Immunology Research. 7:86-99

Advances in single-cell biology have enabled measurements of >40 protein features on millions of immune cells within clinical samples. However, the data analysis steps following cell population identification are susceptible to bias, time-consuming,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0aa3571f3580dbe8489bf70feb3c154
https://doi.org/10.1158/2326-6066.cir-17-0692

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