Health economic analysis of polygenic risk score use in primary prevention of coronary artery disease – A system dynamics model

Autor: Stephen T. Vernon, Stuart Brentnall, Danielle J Currie, Cindy Peng, Michael P. Gray, Giordano Botta, Deo Mujwara, Stephen J. Nicholls, Stuart M. Grieve, Julie Redfern, Clara Chow, Jean-Frederic Levesque, Peter J. Meikle, Garry Jennings, Zanfina Ademi, Andrew Wilson, Gemma A. Figtree

Publikováno v: American Journal of Preventive Cardiology, Vol 18, Iss , Pp 100672- (2024)

Background: Primary prevention programs utilising traditional risk scores fail to identify all individuals who suffer acute cardiovascular events. We aimed to model the impact and cost effectiveness of incorporating a Polygenic risk scores (PRS) into

Externí odkaz: https://doaj.org/article/b786deb82829480a8118d138be0a781e

Integrating a Polygenic Risk Score for Coronary Artery Disease as a Risk‐Enhancing Factor in the Pooled Cohort Equation: A Cost‐Effectiveness Analysis Study

Autor: Deo Mujwara, Geoffrey Henno, Stephen T. Vernon, Siyang Peng, Paolo Di Domenico, Brock Schroeder, George B. Busby, Gemma A Figtree, Giordano Bottà

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 12 (2022)

Background Cardiovascular diseases are the leading cause of death in the United States, yet a significant proportion of adults at high risk remain undetected by standard screening practices. Polygenic risk score for coronary artery disease (CAD‐PRS

Externí odkaz: https://doaj.org/article/6be5a33f46524d94b882b807c7254908

Mathematical modelling to inform 'treat all' implementation in sub-Saharan Africa: a scoping review

Autor: Janne Estill, Jean d’Amour Sinayobye, Denis Nash, Olivia Keiser, April D. Kimmel, Olga Tymejczyk, Rose S Bono, Deo Mujwara

Publikováno v: Journal of Virus Eradication
Journal of Virus Eradication, Vol. 4, No Suppl 2 (2018) pp. 47-54
Journal of Virus Eradication, Vol 4, Iss, Pp 47-54 (2018)

Objective Despite widespread uptake, only half of sub-Saharan African countries have fully implemented the World Health Organization's ‘treat all’ policy, hindering achievement of global HIV targets. We examined literature on mathematical modelli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc710f8067e3432f17ebbaa2d4746b9
https://pubmed.ncbi.nlm.nih.gov/30515314