Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Denzil Bernard"'
Autor:
Haibin Zhou, Jianfeng Lu, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Liu Liu, Donna McEachern, Chao-Yie Yang, Denzil Bernard, Hong Shen, Liangyou Rui, Yi Sun, Shaomeng Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Activation of cullin-RING ligases can be inhibited by targeting DCN1, but selective DCN1 inhibitors with in vivo activity are lacking. Here, the authors develop covalent DCN1 inhibitors that selectively and potently inhibit cullin-3 activation and do
Externí odkaz:
https://doaj.org/article/f1b1354b41f3482fb5e78275ffe16f27
Autor:
Chang Huang, Denzil Bernard, Jiaqi Zhu, Radha Charan Dash, Alexander Chu, Alec Knupp, Anna Hakey, M. Kyle Hadden, Antonio Garmendia, Young Tang
Publikováno v:
Virology Journal, Vol 17, Iss 1, Pp 1-11 (2020)
Abstract Background Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating diseases affecting the pork industry globally. PRRS is caused by PRRS virus (PRRSV). Currently there are no effective treatments agai
Externí odkaz:
https://doaj.org/article/5f2b1d07a8464d7e92b4f6890e5b49e4
Autor:
Haibin Zhou, Jianfeng Lu, Liu Liu, Denzil Bernard, Chao-Yie Yang, Ester Fernandez-Salas, Krishnapriya Chinnaswamy, Stephanie Layton, Jeanne Stuckey, Qing Yu, Weihua Zhou, Zhenqiang Pan, Yi Sun, Shaomeng Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Cullins are central components of the ubiquitin-proteosome system and are activated via a neddylation process mediated by the DCN1–UBC12 complex. Here, the authors develop a small molecule inhibitor of the DCN1–UBC12 interaction that specifically
Externí odkaz:
https://doaj.org/article/a1e0427493d44f3fa81a56f36c37a6f4
Publikováno v:
BioDiscovery, Vol 8, Iss , Pp 1-15 (2013)
Inactivation of the function of tumor suppressor p53 is common in human cancers. In approximately half of human cancers, the tumor suppressor function of p53 is inactivated by deletion or mutation of TP53, the gene encoding p53 protein. In the remain
Externí odkaz:
https://doaj.org/article/1cf09e64d9234501a46a15f021f7614a
Autor:
Jiaqi Zhu, Xin He, Denzil Bernard, Jianing Shen, Yue Su, Andrew Wolek, Brianna Issacs, Neha Mishra, Xiuchun Tian, Antonio Garmendia, Young Tang
Publikováno v:
Journal of Virology. 97
Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses to the swine industry worldwide. Current vaccines cannot provide cross protection against different strains, and there are no effective treatments availabl
Autor:
Sami N. Malek, Tycel Phillips, Suma Devata, Mark Kaminski, Shaomeng Wang, Shilin Xu, Denzil Bernard, Jing Zhang, Zhengfan Xu, Tianyu Sun, Fangyang Wang, Nan Hu
Fig. S1: BTK mutations detected in cDNA in five FL BTK mutant cases. Fig. S2:BTK mutations destabilize the mutant BTK proteins. Fig. S3:BTK mutations do not influence PLCγ2-1217 phosphorylation in reconstituted lymphoma cell lines. Fig. S4:BTK mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8461e4f30565d2118df29c6c23661f16
https://doi.org/10.1158/1078-0432.22483716.v1
https://doi.org/10.1158/1078-0432.22483716.v1
Autor:
Sami N. Malek, Tycel Phillips, Suma Devata, Mark Kaminski, Shaomeng Wang, Shilin Xu, Denzil Bernard, Jing Zhang, Zhengfan Xu, Tianyu Sun, Fangyang Wang, Nan Hu
Supplementary Figure and Table legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a326336ef4a2c385bd1a3879560cd9
https://doi.org/10.1158/1078-0432.22483719.v1
https://doi.org/10.1158/1078-0432.22483719.v1
Autor:
Sami N. Malek, Tycel Phillips, Suma Devata, Mark Kaminski, Shaomeng Wang, Shilin Xu, Denzil Bernard, Jing Zhang, Zhengfan Xu, Tianyu Sun, Fangyang Wang, Nan Hu
Results from IP-mass spec of HA-BTK WT and two HA-BTK mutants and a control (BTK-/- reconstituted with empty vector FG9) and embedded VENN diagram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411e6eb26af08169020a3d8b40784cb6
https://doi.org/10.1158/1078-0432.22483722
https://doi.org/10.1158/1078-0432.22483722
Autor:
Shaomeng Wang, Thomas E. Carey, Carol R. Bradford, Denzil Bernard, Donna McEachern, Yipin Lu, Guoping Wang, Meilan Liu, Joshua A. Bauer, Zaneta Nikolovska-Coleska, Su Qiu, Ke Ding, Sanjeev Shangary
MDM2 oncoprotein binds directly to the p53 tumor suppressor and inhibits its function in cancers retaining wild-type p53. Blocking this interaction using small molecules is a promising approach to reactivate p53 function and is being pursued as a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433d3cfba377d44f73ac65c042036a03
https://doi.org/10.1158/1535-7163.c.6531546
https://doi.org/10.1158/1535-7163.c.6531546
Autor:
Sami N. Malek, Daniel J. Klionsky, Alfred E. Chang, Mark S. Kaminski, Shaomeng Wang, Mehmet Yildiz, Kamlai Saiya-Cork, Denzil Bernard, Luke F. Peterson, Meiyan Jin, Zhang Xiao Ying
Table S1. Yeast strains; Table S2. Primers used for yeasts mutagenesis; Table S3: B-factor for GTP/GDP during MD simulations with WT RRAGC or with point Mutations; Table S4: Energy contribution of each residue (kcal/mol) to GTP and GDP binding; Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fe19f670e032adf0c68c9ab0a5776f
https://doi.org/10.1158/1078-0432.22462820
https://doi.org/10.1158/1078-0432.22462820