Výsledky vyhledávání - "Denysha Carbonell"

Tumor Stem Cell Antigens as Consolidative Active Specific Immunotherapy

Autor: Andrew N. Cornforth, Carol DePriest, Denysha Carbonell, James M. Cubellis, Cheryl Mayorga, Cristina de Leon, Edward F. McClay, Robert O. Dillman, Robin E. Ellis, Thomas Amatruda

Publikováno v: Journal of Immunotherapy. 35:641-649

Only 10% of metastatic melanoma patients survive 5 years, even though many can achieve substantial tumor reduction by surgical resection and/or radiation therapy and/or systemic therapy. An effective, nontoxic, consolidation immunotherapy could benef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a687e33a2a50e16b6ac5748dd5efbcf5
https://doi.org/10.1097/cji.0b013e31826f79c8

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Resistance to the proapoptotic effects of interferon-gamma on melanoma cells used in patient-specific dendritic cell immunotherapy is associated with improved overall survival

Autor: A. W. Fowler, R. O. Dillman, A. N. Cornforth, Denysha Carbonell

Publikováno v: Cancer Immunology, Immunotherapy. 60:123-131

The use of whole cell tumor vaccines and various means of loading antigen onto dendritic cells have been under investigation for over a decade. Induction of apoptosis and the exposure of immune-stimulating proteins are thought to be beneficial for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9132ea69014fa03887d11d7fa7904a18
https://doi.org/10.1007/s00262-010-0925-y

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Establishment of stable cell lines for personalized melanoma cell vaccine

Autor: Senthamil R. Selvan, Abner Fowler, Mepur H. Ravindranath, Denysha Carbonell, Andrea Beatty, Robert O. Dillman

Publikováno v: Melanoma Research. 20:280-292

Personalized vaccine, recognized after the failure of allogenic melanoma whole cell and lysate vaccine phase III trials, involves culturing cells from a patient's own tumor within a short duration and with less passages but with optimized expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b241d5713e8660b68ede48ce4feeee
https://doi.org/10.1097/cmr.0b013e3283390696

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Successful correction of the human β-thalassemia major phenotype using a lentiviral vector

Autor: Geetha Puthenveetil, Ying Yu, Naveen Qureshi, Ping Xia, Punam Malik, Denysha Carbonell, Licheng Zeng, Alan L Hiti, Jessica Scholes, Jiing-Kuan Yee, Shulian Li

Publikováno v: Blood. 104:3445-3453

beta-thalassemias are the most common single gene disorders and are potentially amenable to gene therapy. However, retroviral vectors carrying the human beta-globin cassette have been notoriously unstable. Recently, considerable progress has been mad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea535745eb1a78219a576673073d8249
https://doi.org/10.1182/blood-2004-04-1427

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Abstract CT105: Randomized trial of dendritic vs tumor cell patient-specific vaccines: 5-year analysis

Autor: Robert O. Dillman, Thomas Amatruda, Carol DePriest, Denysha Carbonell, Andrew N. Cornforth, Edward F. McClay

Publikováno v: Cancer Research. 76:CT105-CT105

Eltrapuldencel-T (CLBS20) consists of autologous dendritic cells loaded with antigens from irradiated, self-renewing, autologous tumor cells that potentially present the entire repertoire of unique patient-specific tumor-associated antigens resulting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b10bdb142327410385596fe15c3fe74
https://doi.org/10.1158/1538-7445.am2016-ct105

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Characterization of interferon-γ-treated melanoma tumor cells for use in dendritic cell-based immunotherapy

Autor: Abner Fowler, Robert O. Dillman, Eric Fan, Andrew N. Cornforth, Denysha Carbonell

Publikováno v: Cancer biotherapyradiopharmaceuticals. 26(3)

Efficient delivery of tumor-associated antigens to professional antigen-presenting cells is important for inducing a response in patients receiving cancer immunotherapy. Interferon-gamma (IFN-γ) is used by the immune system to combat viral and funga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239efa318ec6f8bb2e7bbf3b6fca0fd4
https://pubmed.ncbi.nlm.nih.gov/21711093

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Abstract 4845: Microarray analysis of melanoma autologous tumor cell lines used as the source of tumor associated antigens in patient-specific dendritic cell immunotherapy phase II trial in patients with metastatic melanoma

Autor: Gary B. Fogel, Robert O. Dillman, Denysha Carbonell, Andrew N. Cornforth

Publikováno v: Cancer Research. 75:4845-4845

Melanoma cells that are proliferating and self-renewing in short-term cell culture, have the phenotypic and functional characteristics of tumor stem cells, and they express unique patient-specific neoantigens, as well as numerous common melanoma asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::806ac5b687f6eb11edec30b07f7b9ecf
https://doi.org/10.1158/1538-7445.am2015-4845

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Abstract 768: Lymphokine activated killer cell conditioned media induces monocytes to differentiate into a dendritic cell-like/activated monocyte phenotype with cytotoxic potential against glioblastoma

Autor: Andrew N. Cornforth, Denysha Carbonell, Eric Fan, Jessica Alldredge, Gregory J. Lee, Abner Fowler, Robert O. Dillman

Publikováno v: Cancer Research. 71:768-768

Background: Despite advances in surgery and multimodal treatment regimens, Glioblastoma (GBM) continues to have poor overall survival outcomes and associated treatment morbidity. Cell-based immunotherapy is being explored as an option in the treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bb864c429fd2e1dd1e63470ba54b299
https://doi.org/10.1158/1538-7445.am2011-768

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