Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome

Autor: Inderjit Singh, Brooks P. Leitner, Yiwei Wang, Hanming Zhang, Phillip Joseph, Denyse D. Lutchmansingh, Mridu Gulati, Jennifer D. Possick, William Damsky, John Hwa, Paul M. Heerdt, Hyung J. Chun

Publikováno v: Pulmonary Circulation, Vol 13, Iss 2, Pp n/a-n/a (2023)

Abstract Approximately 50% of patients who recover from the acute SARS‐CoV‐2 experience Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. The pathophysiological hallmark of PASC is characterized by impaired system oxygen extraction

Externí odkaz: https://doaj.org/article/564f82af8c8848e1b174afa62350d799

'Long Haulers'

Autor: Denyse D. Lutchmansingh, Jean Paul Higuero Sevilla, Jennifer D. Possick, Mridu Gulati

Publikováno v: Seminars in Respiratory and Critical Care Medicine. 44:130-142

Post-COVID conditions continue to afflict patients long after acute severe acute respiratory syndrome-coronavirus-2 (SARS CoV-2) infection. Over 50 symptoms across multiple organ systems have been reported, with pulmonary, cardiovascular, and neurops

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d037ce005b5f0b625050a575f9df1e5
https://doi.org/10.1055/s-0042-1759568

A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY

Autor: Jennifer D. Possick, Erica L. Herzog, Geoffrey Chupp, Changwan Ryu, Inderjit Singh, Charles S. Dela Cruz, Melissa P. Knauert, Carolyn L. Rochester, Mridu Gulati, Lauren E. Ferrante, Denyse D. Lutchmansingh, Jonathan L. Koff, Danielle Antin-Ozerkis, Lauren Cohn, Mayanka Tickoo, Vikki Winks

Publikováno v: Chest

The severe acute respiratory syndrome coronavirus 2 pandemic poses extraordinary challenges. The tremendous number of coronavirus disease 2019 (COVID-19) cases in the United States has resulted in a large population of survivors with prolonged postin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fd00e0b1e650d499776ac4bf9c55ac
https://doi.org/10.1016/j.chest.2020.10.067

UNEXPLAINED DYSPNEA IN A PATIENT WITH A HISTORY OF COVID-19

Autor: Inderjit Singh, Jennifer D. Possick, Max J Biondi, Denyse D. Lutchmansingh, Mridu Gulati, Phillip Joseph

Publikováno v: Chest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c3427ed5746c024a3d10c8ecafdea2
https://doi.org/10.1016/j.chest.2021.07.2054

Distinguishing features of long COVID identified through immune profiling.

Autor: Klein J; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Wood J; Abilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jaycox JR; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Dhodapkar RM; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Ophthalmology, USC Keck School of Medicine, Los Angeles, CA, USA., Lu P; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Gehlhausen JR; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA., Tabachnikova A; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Greene K; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Tabacof L; Abilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Malik AA; Yale Institute for Global Health, Yale School of Public Health, New Haven, CT, USA., Silva Monteiro V; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Silva J; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Kamath K; SerImmune, Goleta, CA, USA., Zhang M; SerImmune, Goleta, CA, USA., Dhal A; SerImmune, Goleta, CA, USA., Ott IM; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Valle G; Department of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, USA., Peña-Hernández M; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Microbiology, Yale School of Medicine, New Haven, CT, USA., Mao T; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Bhattacharjee B; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Takahashi T; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Lucas C; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., Song E; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., McCarthy D; Abilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Breyman E; Abilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tosto-Mancuso J; Abilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dai Y; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Perotti E; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Akduman K; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Tzeng TJ; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Xu L; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Geraghty AC; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA., Monje M; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Yildirim I; Yale Institute for Global Health, Yale School of Public Health, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.; Department of Pediatrics (Infectious Diseases), Yale New Haven Hospital, New Haven, CT, USA.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Shon J; SerImmune, Goleta, CA, USA., Medzhitov R; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Lutchmansingh D; Department of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, USA., Possick JD; Department of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, USA., Kaminski N; Department of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, USA., Omer SB; Yale Institute for Global Health, Yale School of Public Health, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.; Department of Internal Medicine (Infectious Diseases), Yale School of Medicine, New Haven, CT, USA., Krumholz HM; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT, USA.; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Health Policy and Management, Yale School of Public Health, New Haven, CT, USA., Guan L; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA.; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Dela Cruz CS; Department of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, USA.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA., van Dijk D; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA. david.vandijk@yale.edu.; Department of Computer Science, Yale University, New Haven, CT, USA. david.vandijk@yale.edu.; Department of Internal Medicine (Cardiology), Yale School of Medicine, New Haven, CT, USA. david.vandijk@yale.edu., Ring AM; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. aaron.ring@yale.edu.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA. aaron.ring@yale.edu., Putrino D; Abilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. david.putrino@mountsinai.org.; Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, USA. david.putrino@mountsinai.org., Iwasaki A; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. akiko.iwasaki@yale.edu.; Center for Infection and Immunity, Yale School of Medicine, New Haven, CT, USA. akiko.iwasaki@yale.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. akiko.iwasaki@yale.edu.

Publikováno v: Nature [Nature] 2023 Nov; Vol. 623 (7985), pp. 139-148. Date of Electronic Publication: 2023 Sep 25.