Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus

Autor: Marco Kaiser, Jan Philip Wurm, Birgit Märtens, Udo Bläsi, Denys Pogoryelov, Jens Wöhnert

Publikováno v: FEBS Open Bio, Vol 10, Iss 2, Pp 221-228 (2020)

During translation initiation, the heterotrimeric archaeal translation initiation factor 2 (aIF2) recruits the initiator tRNAi to the small ribosomal subunit. In the stationary growth phase and/or during nutrient stress, Sulfolobus solfataricus aIF2

Externí odkaz: https://doaj.org/article/1bf83389f2c44451b1d0e5ff73795c09

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

Autor: Stefano Woltersdorf, Thomas Duflot, Christophe Morisseau, Victor Hernandez-Olmos, Ewgenij Proschak, Apirat Chaikuad, Franca-M Klingler, Sandra K. Wittmann, Felix Knöll, Dieter Steinhilber, Jan S. Kramer, Felix F Lillich, Angelo Sala, Kerstin Hiesinger, Daniel Merk, Sylvain Fraineau, Jeremy Bellien, Bruce D. Hammock, Jan Heering, Steffen Brunst, Stefan Knapp, G. Enrico Rovati, Julie Rondeaux, Denys Pogoryelov, Carola Buccellati, Matthieu Leuillier

Publikováno v: J Med Chem
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2019, 62 (18), pp.8443-8460. ⟨10.1021/acs.jmedchem.9b00445⟩
Journal of medicinal chemistry, vol 62, iss 18
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (18), pp.8443-8460. ⟨10.1021/acs.jmedchem.9b00445⟩

International audience; The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two different catalytic activities that are located in two distinct domains. Although the physiological role of the C-term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b07e7660f038c7c67a88ec36232ea6
https://doi.org/10.1021/acs.jmedchem.9b00445

Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium

Autor: Shivam, Yadav, Martin, Centola, Mathilda, Glaesmann, Denys, Pogoryelov, Roman, Ladig, Mike, Heilemann, L C, Rai, Özkan, Yildiz, Enrico, Schleiff

Publikováno v: Nature communications. 13(1)

Cyclophilins, or immunophilins, are proteins found in many organisms including bacteria, plants and humans. Most of them display peptidyl-prolyl cis-trans isomerase activity, and play roles as chaperones or in signal transduction. Here, we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9be92895506bf852d615adafe27d51b7
https://pubmed.ncbi.nlm.nih.gov/35354803

Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA

Autor: Kerstin, Hiesinger, Annika, Schott, Jan S, Kramer, René, Blöcher, Finja, Witt, Sandra K, Wittmann, Dieter, Steinhilber, Denys, Pogoryelov, Jana, Gerstmeier, Oliver, Werz, Ewgenij, Proschak

Publikováno v: ACS Med Chem Lett

[Image: see text] Multitarget anti-inflammatory drugs interfering with the arachidonic acid cascade exhibit superior efficacy. In this study, a prototype dual inhibitor of soluble epoxide hydrolase (sEH) and LTA(4) hydrolase (LTA(4)H) with submicromo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e59bd384a1278a1fa8ee8f5c81cd521
https://pubmed.ncbi.nlm.nih.gov/32184960

Thermodynamic properties of leukotriene A 4 hydrolase inhibitors

Autor: René Bloecher, Lena Kalinowsky, Dieter Steinhilber, Jan S. Kramer, Stefan Knapp, Ewgenij Proschak, Jan Heering, Denys Pogoryelov, Sandra K. Wittmann

Publikováno v: Bioorganic & Medicinal Chemistry. 24:5243-5248

The leukotriene A4 hydrolase (LTA4H) is a bifunctional enzyme, containing a peptidase and a hydrolase activity both activities having opposing functions regulating inflammatory response. The hydrolase activity is responsible for the conversion of leu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e01724ec14858f9643587b7f853aadb
https://doi.org/10.1016/j.bmc.2016.08.047