Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

Autor: Laustsen, A, Bak, RO, Krapp, C, Kjær, L, Egedahl, JH, Petersen, CC, Pillai, S, Tang, HQ, Uldbjerg, N, Porteus, M, Roan, NR, Nyegaard, M, Denton, PW, Jakobsen, MR

Publikováno v: Nature communications, vol 9, iss 1
Laustsen, A; Bak, RO; Krapp, C; Kjær, L; Egedahl, JH; Petersen, CC; et al.(2018). Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.. Nature communications, 9(1), 3525. doi: 10.1038/s41467-018-05816-y. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3979k69n

Plasmacytoid dendritic cells (pDC) are essential for immune competence. Here we show that pDC precursor differentiated from human CD34+ hematopoietic stem and progenitor cells (HSPC) has low surface expression of pDC markers, and has limited inductio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::eda1babf21c913904b72d574a54963df
https://escholarship.org/uc/item/3979k69n

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TLR9 agonism differentially impacts human NK cell-mediated direct killing and antibody-dependent cell-mediated cytotoxicity.

Autor: Mahr AR; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Bennett-Boehm MMC; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA.; Department of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, NE, USA., Rothemejer FH; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Weber IS; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Regan AK; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Franzen JQ; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Bisson CR; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Truong AN; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Olesen R; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Schleimann MH; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Rauter CM; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Smith AL; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA., El-Gamal D; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Søgaard OS; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Tolstrup M; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Denton PW; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA. pdenton@unomaha.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Jun 25; Vol. 14 (1), pp. 14595. Date of Electronic Publication: 2024 Jun 25.

Development and implementation of natural killer cell simultaneous ADCC and direct killing assay.

Autor: Bennett-Boehm MMC; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA.; Department of Information Science and Technology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Mahr AR; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Hartwell ST; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Regan AK; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Weber IS; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Blackmon A; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Bisson CR; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Truong AN; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Circo BA; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Nienhueser J; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Rogers DR; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Booher N; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Rajagopalan N; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Martens JWS; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Denton PW; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA.

Publikováno v: Heliyon [Heliyon] 2023 Nov 28; Vol. 9 (12), pp. e22991. Date of Electronic Publication: 2023 Nov 28 (Print Publication: 2023).

Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial.

Autor: Gunst JD; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Højen JF; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Pahus MH; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Rosás-Umbert M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Stiksrud B; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway., McMahon JH; Department of Infectious Diseases, Alfred Hospital, Melbourne, VIC, Australia., Denton PW; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Nielsen H; Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Johansen IS; Department of Infectious Diseases, Odense University Hospital, University of Southern Denmark, Odense, Denmark., Benfield T; Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Leth S; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Internal Medicine, Gødstrup Hospital, Gødstrup, Denmark., Gerstoft J; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Viro-Immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Østergaard L; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Schleimann MH; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Olesen R; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Støvring H; Department of Public Health, Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark, Odense, Denmark., Vibholm L; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Weis N; Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Dyrhol-Riise AM; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Pedersen KBH; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Lau JSY; Department of Infectious Diseases, Alfred Hospital, Melbourne, VIC, Australia.; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Copertino DC Jr; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Linden N; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Huynh TT; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Jones RB; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Lewin SR; Department of Infectious Diseases, Alfred Hospital, Melbourne, VIC, Australia.; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Tolstrup M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Rasmussen TA; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA., Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Reikvam DH; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Søgaard OS; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. olesoega@rm.dk.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark. olesoega@rm.dk.

Publikováno v: Nature medicine [Nat Med] 2023 Oct; Vol. 29 (10), pp. 2547-2558. Date of Electronic Publication: 2023 Sep 11.