TLR9 agonism differentially impacts human NK cell-mediated direct killing and antibody-dependent cell-mediated cytotoxicity.

Autor: Mahr AR; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Bennett-Boehm MMC; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA.; Department of Interdisciplinary Informatics, University of Nebraska at Omaha, Omaha, NE, USA., Rothemejer FH; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Weber IS; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Regan AK; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Franzen JQ; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Bisson CR; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Truong AN; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Olesen R; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Schleimann MH; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Rauter CM; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Smith AL; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA., El-Gamal D; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA., Søgaard OS; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Tolstrup M; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Denton PW; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA. pdenton@unomaha.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Jun 25; Vol. 14 (1), pp. 14595. Date of Electronic Publication: 2024 Jun 25.

Development and implementation of natural killer cell simultaneous ADCC and direct killing assay.

Autor: Bennett-Boehm MMC; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA.; Department of Information Science and Technology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Mahr AR; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Hartwell ST; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Regan AK; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Weber IS; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Blackmon A; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Bisson CR; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Truong AN; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Circo BA; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Nienhueser J; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Rogers DR; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Booher N; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Rajagopalan N; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Martens JWS; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Denton PW; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA.

Publikováno v: Heliyon [Heliyon] 2023 Nov 28; Vol. 9 (12), pp. e22991. Date of Electronic Publication: 2023 Nov 28 (Print Publication: 2023).

Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial.

Autor: Gunst JD; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Højen JF; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Pahus MH; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Rosás-Umbert M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Stiksrud B; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway., McMahon JH; Department of Infectious Diseases, Alfred Hospital, Melbourne, VIC, Australia., Denton PW; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Nielsen H; Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Johansen IS; Department of Infectious Diseases, Odense University Hospital, University of Southern Denmark, Odense, Denmark., Benfield T; Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Leth S; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Internal Medicine, Gødstrup Hospital, Gødstrup, Denmark., Gerstoft J; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Viro-Immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Østergaard L; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Schleimann MH; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Olesen R; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Støvring H; Department of Public Health, Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark, Odense, Denmark., Vibholm L; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Weis N; Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Dyrhol-Riise AM; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Pedersen KBH; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Lau JSY; Department of Infectious Diseases, Alfred Hospital, Melbourne, VIC, Australia.; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Copertino DC Jr; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Linden N; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Huynh TT; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Jones RB; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Lewin SR; Department of Infectious Diseases, Alfred Hospital, Melbourne, VIC, Australia.; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.; Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Tolstrup M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Rasmussen TA; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA., Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Reikvam DH; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Søgaard OS; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. olesoega@rm.dk.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark. olesoega@rm.dk.

Publikováno v: Nature medicine [Nat Med] 2023 Oct; Vol. 29 (10), pp. 2547-2558. Date of Electronic Publication: 2023 Sep 11.

Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8 ⁺ T cell immunity.

Autor: Rosás-Umbert M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Gunst JD; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Pahus MH; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Olesen R; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Schleimann M; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Denton PW; Department of Biology, University of Nebraska at Omaha, Omaha, NE, USA., Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Ward A; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Kinloch NN; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Copertino DC; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Escribà T; IrsiCaixa, AIDS Research Institute, Institute for Health Science Research Germans Trias i Pujol (IGTP), Hospital Germans Trias I Pujol, Badalona, Spain., Llano A; IrsiCaixa, AIDS Research Institute, Institute for Health Science Research Germans Trias i Pujol (IGTP), Hospital Germans Trias I Pujol, Badalona, Spain., Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Brad Jones R; Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Mothe B; IrsiCaixa, AIDS Research Institute, Institute for Health Science Research Germans Trias i Pujol (IGTP), Hospital Germans Trias I Pujol, Badalona, Spain.; CIBERINFEC, ISCIII, Madrid, Spain.; Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Barcelona, Spain., Brander C; IrsiCaixa, AIDS Research Institute, Institute for Health Science Research Germans Trias i Pujol (IGTP), Hospital Germans Trias I Pujol, Badalona, Spain.; Centre for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Fox J; Department of Genitourinary Medicine and Infectious Disease, Guys and St Thomas' National Health Service Trust, London, UK.; Department of Genitourinary Medicine and Infectious Disease, The National Institute for Health Research Biomedical Research Centre, King's College London, London, UK., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA., Fidler S; Department of Infectious Diseases, Imperial College London, London, UK.; The National Institute for Health Research, Imperial Biomedical Research Centre, London, UK., Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA., Tolstrup M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Søgaard OS; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. olesoega@rm.dk.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark. olesoega@rm.dk.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 29; Vol. 13 (1), pp. 6473. Date of Electronic Publication: 2022 Oct 29.

CD169 (Siglec-1) as a Robust Human Cell Biomarker of Toll-Like Receptor 9 Agonist Immunotherapy.

Autor: Lende SSF; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Pahus MH; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Monrad I; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Olesen R; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Mahr AR; Department of Biology, University of Nebraska at Omaha, Omaha, NE, United States., Vibholm LK; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Østergaard L; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Søgaard OS; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Andersen AHF; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Denton PW; Department of Biology, University of Nebraska at Omaha, Omaha, NE, United States., Tolstrup M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Jul 05; Vol. 12, pp. 919097. Date of Electronic Publication: 2022 Jul 05 (Print Publication: 2022).