Targeting lysine acetylation readers and writers.

Autor: Zhou MM; Departments of Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ming-ming.zhou@mssm.edu., Cole PA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. pacole@bwh.harvard.edu.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. pacole@bwh.harvard.edu.

Publikováno v: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.

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The combination of decitabine with multi-omics confirms the regulatory pattern of the correlation between DNA methylation of the CACNA1C gene and atrial fibrillation.

Autor: Yang, Yuling, Li, Qijun, Liu, Xiaoning, Shao, Caixia, Yang, Heng, Niu, Siquan, Peng, Hong, Meng, Xiangguang

Publikováno v: Frontiers in Pharmacology; 2024, p1-18, 18p

Histone acetyltransferases and histone deacetyl transferases play crucial role during oogenesis and early embryo development.

Autor: Bozdemir N; Department of Histology and Embryology, Ankara Medipol University School of Medicine, Ankara, Turkey., Uysal F; Department of Histology and Embryology, Ankara Medipol University School of Medicine, Ankara, Turkey.

Publikováno v: Genesis (New York, N.Y. : 2000) [Genesis] 2023 Sep; Vol. 61 (5), pp. e23518. Date of Electronic Publication: 2023 May 25.

CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death.

Autor: Pavlou, Sofia^1,2 (AUTHOR) sof_pav@hotmail.com, Foskolou, Stefanie^1,2 (AUTHOR), Patikas, Nikolaos¹ (AUTHOR), Field, Sarah F.^1,2 (AUTHOR), Papachristou, Evangelia K.³ (AUTHOR), Santos, Clive D'³ (AUTHOR), Edwards, Abigail R.³ (AUTHOR), Kishore, Kamal³ (AUTHOR), Ansari, Rizwan¹ (AUTHOR), Rajan, Sandeep S.^1,2 (AUTHOR), Fernandes, Hugo J. R.^1,2 (AUTHOR), Metzakopian, Emmanouil¹ (AUTHOR) em698@medschl.cam.ac.uk

Publikováno v: Scientific Reports. 3/9/2023, Vol. 13 Issue 1, p1-11. 11p.