MeCP2 gene therapy ameliorates disease phenotype in mouse model for Pitt Hopkins syndrome

Autor: Dennys, Cassandra N., Vermudez, Sheryl Anne D., Deacon, Robert J.M., Sierra-Delgado, J. Andrea, Rich, Kelly, Zhang, Xiaojin, Buch, Aditi, Weiss, Kelly, Moxley, Yuta, Rajpal, Hemangi, Espinoza, Francisca D., Powers, Samantha, Ávila, Ariel S., Gogliotti, Rocco G., Cogram, Patricia, Niswender, Colleen M., Meyer, Kathrin C.

Publikováno v: In Neurotherapeutics September 2024 21(5)

EphA4 targeting agents protect motor neurons from cell death induced by amyotrophic lateral sclerosis -astrocytes

Autor: Dennys, Cassandra, Baggio, Carlo, Rodrigo, Rochelle, Roussel, Florence, Kulinich, Anna, Heintzman, Sarah, Fox, Ashley, Kolb, Stephen J., Shaw, Pamela J., Ethell, Iryna M., Pellecchia, Maurizio, Meyer, Kathrin C.

Publikováno v: In iScience 16 September 2022 25(9)

PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD

Autor: Pilotto, Federica, Schmitz, Alexander, Maharjan, Niran, Diab, Rim, Odriozola, Adolfo, Tripathi, Priyanka, Yamoah, Alfred, Scheidegger, Olivier, Oestmann, Angelina, Dennys, Cassandra N, Sinha Ray, Shrestha, Rodrigo, Rochelle, Kolb, Stephen, Aronica, Eleonora, Di Santo, Stefano, Widmer, Hans Rudolf, Charlet-Berguerand, Nicolas, Selvaraj, Bhuvaneish T, Chandran, Siddharthan, Meyer, Kathrin, Zuber, Benoît, Goswami, Anand, Weis, Joachim, Saxena, Smita

Publikováno v: Pilotto, F, Schmitz, A, Maharjan, N, Diab, R, Odriozola, A, Tripathi, P, Yamoah, A, Scheidegger, O, Oestmann, A, Dennys, C N, Sinha Ray, S, Rodrigo, R, Kolb, S, Aronica, E, Di Santo, S, Widmer, H R, Charlet-Berguerand, N, Selvaraj, B T, Chandran, S, Meyer, K, Zuber, B, Goswami, A, Weis, J & Saxena, S 2022, ' PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD ', Acta Neuropathologica . https://doi.org/10.1007/s00401-022-02494-5
Pilotto, Federica; Schmitz, Alexander; Maharjan, Niran; Diab, Rim; Odriozola, Adolfo; Tripathi, Priyanka; Yamoah, Alfred; Scheidegger, Olivier; Oestmann, Angelina; Dennys, Cassandra N; Sinha Ray, Shrestha; Rodrigo, Rochelle; Kolb, Stephen; Aronica, Eleonora; Di Santo, Stefano; Widmer, Hans Rudolf; Charlet-Berguerand, Nicolas; Selvaraj, Bhuvaneish T; Chandran, Siddharthan; Meyer, Kathrin; ... (2022). PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD. Acta neuropathologica, 144(5), pp. 939-966. Springer-Verlag 10.1007/s00401-022-02494-5
Pilotto, F, Schmitz, A, Maharjan, N, Diab, R, Odriozola, A, Tripathi, P, Yamoah, A, Scheidegger, O, Oestmann, A, Dennys, C N, Sinha Ray, S, Rodrigo, R, Kolb, S, Aronica, E, di Santo, S, Widmer, H R, Charlet-Berguerand, N, Selvaraj, B T, Chandran, S, Meyer, K, Zuber, B, Goswami, A, Weis, J & Saxena, S 2022, ' PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD ', Acta Neuropathologica, vol. 144, no. 5, pp. 939-966 . https://doi.org/10.1007/s00401-022-02494-5
Acta neuropathologica 144(5), 939-966 (2022). doi:10.1007/s00401-022-02494-5
Acta neuropathologica, 144(5), 939-966. Springer Verlag
Acta Neuropathologica, 144(5), 939-966. Springer Verlag

Acta neuropathologica 144(5), 939-966 (2022). doi:10.1007/s00401-022-02494-5
Published by Springer, Berlin ; Heidelberg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5cf249b50a70ecbaf50f60dd560d99
https://hdl.handle.net/20.500.11820/c3ba6926-b9b1-489d-ad10-d0e576e890e2

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Amyotrophic Lateral Sclerosis: mechanism behind mutant SOD toxicity and improving current therapeutic strategies

Autor: Dennys, Cassandra

Publikováno v: Electronic Theses and Dissertations.

Amyotrophic Lateral Sclerosis (ALS) is an always lethal motor neuron disease with unknown pathogenesis. Inhibitors of the molecular chaperone heat shock protein 90 (Hsp90) have limited neuroprotection in some models of motor neuron degeneration. Howe

Externí odkaz: https://stars.library.ucf.edu/etd/1213
https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=2212&context=etd