Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Denny Mahlin"'
Publikováno v:
Pharmaceutics, Vol 11, Iss 9, p 425 (2019)
This study shows the importance of the chosen method for assessing the glass-forming ability (GFA) and glass stability (GS) of a drug compound. Traditionally, GFA and GS are established using in situ melt-quenching in a differential scanning calorime
Externí odkaz:
https://doaj.org/article/7278bafa65fc4e268a7251765b5cbc04
Autor:
Khadijah Edueng, Denny Mahlin, Johan Gråsjö, Olivia Nylander, Manish Thakrani, Christel A.S. Bergström
Publikováno v:
Molecules, Vol 24, Iss 15, p 2731 (2019)
This study explores the effect of physical aging and/or crystallization on the supersaturation potential and crystallization kinetics of amorphous active pharmaceutical ingredients (APIs). Spray-dried, fully amorphous indapamide, metolazone, glibencl
Externí odkaz:
https://doaj.org/article/e3f88fc41bdd4a11a59f234d01e301f3
Autor:
Khadijah Edueng, Aleksei Kabedev, Alyssa Ekdahl, Denny Mahlin, John Baumann, Deanna Mudie, Christel A.S. Bergström
Publikováno v:
International journal of pharmaceutics. 613
Robust and reliable in vivo performance of medicines based on amorphous solid dispersions (ASDs) depend on maintenance of physical stability and efficient supersaturation. However, molecular drivers of these two kinetic processes are poorly understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e70c890d50428bfe634a0e8fb72e83
https://pubmed.ncbi.nlm.nih.gov/34896563
https://pubmed.ncbi.nlm.nih.gov/34896563
Publikováno v:
International Journal of Pharmaceutics. 529:116-122
Atomic layer deposition (ALD) enables deposition of dense nanometer thick metal oxide nanoshells on powder particles with precise thickness control. This leads to products with low weight fraction coating, also when depositing on nano- or micron size
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab24448ccb6f27b5dc423ccd9daaf6a
https://doi.org/10.1016/j.ijpharm.2017.06.046
https://doi.org/10.1016/j.ijpharm.2017.06.046
Autor:
Denny Mahlin, Khadijah Edueng, Manish Thakrani, Olivia Nylander, Christel A. S. Bergström, Johan Gråsjö
Publikováno v:
Molecules, Vol 24, Iss 15, p 2731 (2019)
Molecules
Volume 24
Issue 15
Molecules
Volume 24
Issue 15
This study explores the effect of physical aging and/or crystallization on the supersaturation potential and crystallization kinetics of amorphous active pharmaceutical ingredients (APIs). Spray-dried, fully amorphous indapamide, metolazone, glibencl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fc881b3547f0dd5fcd5f90f81884c6
https://www.mdpi.com/1420-3049/24/15/2731
https://www.mdpi.com/1420-3049/24/15/2731
Publikováno v:
International Journal of Pharmaceutics
Graphical abstract
Amorphous materials are inherently unstable and tend to crystallize upon storage. In this study, we investigated the extent to which the physical stability and inherent crystallization tendency of drugs are related to their gl
Amorphous materials are inherently unstable and tend to crystallize upon storage. In this study, we investigated the extent to which the physical stability and inherent crystallization tendency of drugs are related to their gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe9141340dffcc29e953b1b4cba5782
https://doi.org/10.1016/j.ijpharm.2015.08.101
https://doi.org/10.1016/j.ijpharm.2015.08.101
Publikováno v:
Pharmaceutical Research
The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability issue associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a962f9768ddd6bc25b826b03dc7d63
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341852
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341852
Publikováno v:
Journal of Chemical Information and Modeling. 54:3396-3403
Glass transition temperature (Tg) is an important inherent property of an amorphous solid material which is usually determined experimentally. In this study, the relation between Tg and melting temperature (Tm) was evaluated using a data set of 71 st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e9ca4c080b3f5ae7befb7846f5662f
https://doi.org/10.1021/ci5004834
https://doi.org/10.1021/ci5004834
Autor:
Joakim Bjerketorp, Leticia Pizzul, Karin Önneby, Sebastian Håkansson, Denny Mahlin, Per Wessman
Publikováno v:
World Journal of Microbiology and Biotechnology. 29:1399-1408
In this study we have compared the ability of the organic polymers Ficoll and hydroxyethylcellulose (HEC) and the disaccharides sucrose and trehalose to support cell survival during freeze-drying and subsequent storage of a gram-negative Sphingobium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b135f9a71bb63b6a9f4c9c09d4e361
https://doi.org/10.1007/s11274-013-1303-7
https://doi.org/10.1007/s11274-013-1303-7
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 32(49)
This study aims at investigating the molecular level organization and molecular mobility in montmorillonite nanocomposites with the uncharged organic low-molecular-weight compound lactose commonly used in pharmaceutical drug delivery, food technology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453a21a908a06e9d05326abdc595c9ec
https://pubmed.ncbi.nlm.nih.gov/27951698
https://pubmed.ncbi.nlm.nih.gov/27951698