Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Denny L Cottle"'
Autor:
Tia DiTommaso, Lynelle K Jones, Denny L Cottle, WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E Vancollie, Fiona M Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P Steel, John P Sundberg, Jacqueline K White, Ian M Smyth
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004705 (2014)
The skin is a highly regenerative organ which plays critical roles in protecting the body and sensing its environment. Consequently, morbidity and mortality associated with skin defects represent a significant health issue. To identify genes importan
Externí odkaz:
https://doaj.org/article/03c745db72054c98b2c15844f603b5cc
Autor:
Tia DiTommaso, Denny L Cottle, Helen B Pearson, Holger Schlüter, Pritinder Kaur, Patrick O Humbert, Ian M Smyth
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004706 (2014)
Keratins are cytoskeletal intermediate filament proteins that are increasingly being recognised for their diverse cellular functions. Here we report the consequences of germ line inactivation of Keratin 76 (Krt76) in mice. Homozygous disruption of th
Externí odkaz:
https://doaj.org/article/8f10fdad58e248f49215c890e550eb36
Autor:
Ming Shen Tham, Denny L. Cottle, Allara K. Zylberberg, Kieran M. Short, Lynelle K. Jones, Perkin Chan, Sarah E. Conduit, Jennifer M. Dyson, Christina A. Mitchell, Ian M. Smyth
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA’s role in regulating renal cyst development we conditionally deleted the gene in mouse mode
Externí odkaz:
https://doaj.org/article/226bfb45e8934ee1ba253ad4552b6197
Autor:
Stephanie Grabow, Lachlan Whitehead, Stefan P Glaser, Verena C. Wimmer, Alex R. D. Delbridge, Ian M. Smyth, Ming Shen Tham, Andreas Strasser, Marco J Herold, Kerstin Brinkmann, Denny L Cottle, Duong Nhu, Guillaume Lessene, Paul Waring, Gemma L. Kelly
Publikováno v:
EMBO J
Studies of gene-targeted mice identified the roles of the different pro-survival BCL-2 proteins during embryogenesis. However, little is known about the role(s) of these proteins in adults in response to cytotoxic stresses, such as treatment with ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d646b2b2367bdbabef781d7b1d258cd6
https://europepmc.org/articles/PMC7737616/
https://europepmc.org/articles/PMC7737616/
A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder
Autor:
Denny L Cottle, John E. Dowling, Amali Mallawaarachchi, Andrew Mallett, Cas Simons, Hugh J. McCarthy, Peter D. Yurchenco, Kieran M. Short, Karen K. McKee, Ian M. Smyth, Rachel Lam, J. Miner, Stephen I. Alexander, Lynn Pais, Lynelle K. Jones, Maya Aleksandrova
Publikováno v:
Development
Laminin alpha 5 (LAMA5) is a member of a large family of proteins which trimerize and then polymerise to form a central component of all basement membranes. Consequently, the protein plays an instrumental role in shaping the normal development of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5463bff8b7ca61541b4b8cc7e20aa420
https://europepmc.org/articles/PMC7540250/
https://europepmc.org/articles/PMC7540250/
Autor:
Ying Fu, Helena C. Parkington, Nigora Mukhamedova, Gloria M. A. Ursino, Natalie A. Mellett, Lynelle K. Jones, Stacey Fynch, Peter J. Meikle, Dmitri Sviridov, Hann Low, Peter Thorn, Jacquelyn M. Weir, Michael Ditiatkovski, Denny L Cottle, Wan Jun Gan, Helen E. Thomas, Partha Pratim Das, Ming Shen Tham, Ian M. Smyth
Publikováno v:
EMBO Rep
Dysregulation of lipid homeostasis is intimately associated with defects in insulin secretion, a key feature of type 2 diabetes. Here, we explore the role of the putative lipid transporter ABCA12 in regulating insulin secretion from β-cells. Mice wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52df1a938c36888ea1e995a19b81210b
https://europepmc.org/articles/PMC7054684/
https://europepmc.org/articles/PMC7054684/
Autor:
Sebastian Dworkin, Ian M. Smyth, Suraya Roslan, Stephen M. Jane, Fiona H Tan, Charbel Darido, Rhys D. Brady, Denny L Cottle, Seema Srivastava, Stephen J. Goldie, Darren D. Partridge, Alana Auden
Publikováno v:
Cell Death and Disease, Vol 9, Iss 11, Pp 1-12 (2018)
Cell Death & Disease
Cell Death & Disease
Identifying soluble factors that influence epidermal integrity is critical for the development of preventative and therapeutic strategies for disorders such as ichthyosis, psoriasis, dermatitis and epidermal cancers. The transcription factor Grainyhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a732ea0766c69b6dbeb9b0a78ba04f
http://link.springer.com/article/10.1038/s41419-018-0901-6
http://link.springer.com/article/10.1038/s41419-018-0901-6
Autor:
Anne E O'Connor, Denny L Cottle, D. Jo Merriner, Ian M. Smyth, Christiane Pleuger, Moira K O'Bryan, Daniela Fietz, Martin Bergmann, Madeleine Cooper, Mari S. Lehti
Publikováno v:
Endocrinology. 160(11)
Ciliated bronchial epithelium 1 (CBE1) is a microtubule-associated protein localized to the manchette and developing flagellum during spermiogenesis, and associated with sperm maturation arrest in humans. It was hypothesized that CBE1 functions in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50140410a7a2b8d78e6e9b2e7acb9a9
https://pubmed.ncbi.nlm.nih.gov/31504408
https://pubmed.ncbi.nlm.nih.gov/31504408
Autor:
Lynelle K. Jones, Denny L Cottle, Allara K. Zylberberg, Gloria M. A. Ursino, Ian M. Smyth, Ming Shen Tham
Publikováno v:
Cell Reports Medicine
Summary Mutations in the lipid transport protein ABCA12 cause the life-threatening skin condition harlequin ichthyosis (HI), which is characterized by the loss of skin barrier function, inflammation, and dehydration. Inflammatory responses in HI incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eee1c152cd5894e6577b675765734e3
https://doi.org/10.1016/j.xcrm.2020.100129
https://doi.org/10.1016/j.xcrm.2020.100129
Autor:
Sally Chi Ieng Ip, J. M. Weir, Peter J. Meikle, Edel A. O'Toole, Ian M. Smyth, Denny L Cottle, David P. Kelsell, Lynelle K. Jones
Publikováno v:
British Journal of Dermatology. 177
Harlequin Ichythosis (HI) is a severe skin disease caused by mutations in the lipid transport protein, ABCA12. This disrupts extracellular lipid deposition; limiting barrier function and resulting in the differentiation of a thickened, restrictive ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41d7c02dea9651360e621328276997d
https://doi.org/10.1111/bjd.15642
https://doi.org/10.1111/bjd.15642