Výsledky vyhledávání - "Dennis Y. Tse"

Akademický článek

The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice

Autor: Dennis Y. Tse, Seong Jae Kim, Inyoung Chung, Feng He, Theodore G. Wensel, Samuel M. Wu

Publikováno v: International Journal of Ophthalmology, Vol 10, Iss 9, Pp 1361-1369 (2017)

AIM: To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into mice. METHODS: Forty-eight 6-8-week-old C57BL/6J mice were used in this study. Simvastatin was intravitreally injected into the right eye of ea

Externí odkaz: https://doaj.org/article/bf9d8b76b8d34325ab99da8276607dd0

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Akademický článek

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)

The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis. Here authors show that trehalose, an mTOR-independent autophagy inducer, alleviates the pathological phenotypes in a mouse model of neurodegenerative disease. Trehalose

Externí odkaz: https://doaj.org/article/9d01b8cdb7714197a5184f986c9a6f8a

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Akademický článek

Correction: Corrigendum: mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-3 (2017)

Nature Communications 8: Article number: 14338 (2017); Published: 6 February 2017; Updated: 13 June 2017 This Article contains errors in Figs 2 and 3, for which we apologize. In Fig. 2c, the four images were inadvertently duplicated from the images i

Externí odkaz: https://doaj.org/article/ad88932b47944958b842a6eaf7d2a132

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Changes in relative peripheral refraction in children who switched from single‐vision lenses to Defocus Incorporated Multiple Segments lenses

Autor: Han Yu Zhang, Carly Siu Yin Lam, Wing Chun Tang, Paul H. Lee, Dennis Y. Tse, Chi Ho To

Publikováno v: Ophthalmic and Physiological Optics. 43:319-326

To investigate changes in relative peripheral refraction (RPR) associated with myopia progression in children who wore single-vision (SV) lenses for 2 years and switched to Defocus Incorporated Multiple Segments (DIMS) lenses in the third year versus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e345580e787577f6c5fa0bdea926ded5
https://doi.org/10.1111/opo.13086

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Unmasking inhibition prolongs neuronal function in retinal degeneration mouse model

Autor: Chung Him So, Qin Wang, Dennis Y. Tse, Seema Banerjee, Feng Pan, Chun Ting Qiu, Béla Völgyi, Hang-I Christie Lam

Publikováno v: The FASEB Journal. 34:15282-15299

All neurodegenerative diseases involve a relatively long period of timeframe from the onset of the disease to complete loss of functions. Extending this timeframe, even at a reduced level of function, would improve the quality of life of patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8718c4d399ebe226180d8f45a6be3042
https://doi.org/10.1096/fj.202001315rr

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Targeting Lysosomes to Reverse Hydroquinone-Induced Autophagy Defects and Oxidative Damage in Human Retinal Pigment Epithelial Cells

Autor: Henry H. L. Chan, Samuel Abokyi, Christie Hang I Lam, Feng Pan, Dennis Y. Tse, Chi Ho To, Kirk Patrick Catral, Sze-Wan Shan

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9042, p 9042 (2021)
Volume 22
Issue 16

In age-related macular degeneration (AMD), hydroquinone (HQ)-induced oxidative damage in retinal pigment epithelium (RPE) is believed to be an early event contributing to dysregulation of inflammatory cytokines and vascular endothelial growth factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52cb93d9881d6392837f2c16914700e
https://pubmed.ncbi.nlm.nih.gov/34445748

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Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression: a 2-year randomised clinical trial

Autor: Dennis Y. Tse, Hua Qi, Wing Chun Tang, Keigo Hasegawa, Rachel Ka Man Chun, Chi Ho To, Takashi Hatanaka, Roger Pak Kin Lee, Carly S.Y. Lam

Publikováno v: The British Journal of Ophthalmology

AimTo determine if ‘Defocus Incorporated Multiple Segments’ (DIMS) spectacle lenses slow childhood myopia progression.MethodsA 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8–13 years, with myopia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44bdcca0ab8bc6230a3801d13e95498
https://doi.org/10.1136/bjophthalmol-2018-313739

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SWATH Based Quantitative Proteomics Reveals Significant Lipid Metabolism in Early Myopic Guinea Pig Retina

Autor: Jingfang Bian, King-Kit Li, Ying-Hon Sze, Chi Ho To, Thomas Chuen Lam, Sally A McFadden, Carly S.Y. Lam, Dennis Y. Tse

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 4721, p 4721 (2021)
Volume 22
Issue 9

Most of the previous myopic animal studies employed a single-candidate approach and lower resolution proteomics approaches that were difficult to detect minor changes, and generated limited systems-wide biological information. Hence, a complete pictu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2043923851576c5b4e7b54f35d0465
https://pubmed.ncbi.nlm.nih.gov/33946922

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High-pH reversed-phase fractionated neural retina proteome of normal growing C57BL/6 mouse

Autor: Dennis Y. Tse, Chi Ho To, Ying Hon Sze, Thomas Chuen Lam, Jimmy Ka Wai Cheung, King Kit Li, Q Zhao

Publikováno v: Scientific Data
Scientific Data, Vol 8, Iss 1, Pp 1-9 (2021)

The retina is a key sensory tissue composed of multiple layers of cell populations that work coherently to process and decode visual information. Mass spectrometry-based proteomics approach has allowed high-throughput, untargeted protein identificati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ac9e27739f2f23119dfc3fa102ec7c
https://pubmed.ncbi.nlm.nih.gov/33500412

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Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models

Autor: Chi Ho To, Tim T Lam, Samuel Abokyi, Dennis Y. Tse

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)

Age-related macular degeneration (AMD) is a common cause of visual impairment in the elderly. There are very limited therapeutic options for AMD with the predominant therapies targeting vascular endothelial growth factor (VEGF) in the retina of patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9483225b139be86181a4eed6e7274de8
http://europepmc.org/articles/PMC7035553

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