Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Dennis Y. Liu"'
Autor:
Darryl M. Wilson, Daniel J. Driedger, Dennis Y. Liu, Sandra Keerthisinghe, Adrian Hermann, Christoph Bieniossek, Roger G. Linington, Robert A. Britton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Polyketide or polyketide-like macrolides (pMLs) continue to serve as a source of inspiration for drug discovery. However, their inherent structural and stereochemical complexity challenges efforts to explore related regions of chemical space
Externí odkaz:
https://doaj.org/article/ade8a36322684d49b417cc35ec35dfe3
Autor:
Dennis Y. Liu, Laura Phillips, Darryl M. Wilson, Kelly M. Fulton, Susan M. Twine, Alex Wong, Roger G. Linington
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Collateral sensitivity (CS), whereby resistance to one drug is accompanied by increased sensitivity to another, provides new opportunities for antimicrobial drug discovery. Here, Liu et al. screen large chemical libraries across 29 drug-resistant E.
Externí odkaz:
https://doaj.org/article/9fab3deea0464cd0a3a2a46120dc904a
Autor:
Sanghoon Lee, Jeffrey A. van Santen, Nima Farzaneh, Dennis Y. Liu, Cameron R. Pye, Tim U. H. Baumeister, Weng Ruh Wong, Roger G. Linington
Publikováno v:
ACS Central Science, Vol 8, Iss 2, Pp 223-234 (2022)
Externí odkaz:
https://doaj.org/article/03caca7559a84f6e8830859177438647
Autor:
Jeffrey A. van Santen, Grégoire Jacob, Amrit Leen Singh, Victor Aniebok, Marcy J. Balunas, Derek Bunsko, Fausto Carnevale Neto, Laia Castaño-Espriu, Chen Chang, Trevor N. Clark, Jessica L. Cleary Little, David A. Delgadillo, Pieter C. Dorrestein, Katherine R. Duncan, Joseph M. Egan, Melissa M. Galey, F.P. Jake Haeckl, Alex Hua, Alison H. Hughes, Dasha Iskakova, Aswad Khadilkar, Jung-Ho Lee, Sanghoon Lee, Nicole LeGrow, Dennis Y. Liu, Jocelyn M. Macho, Catherine S. McCaughey, Marnix H. Medema, Ram P. Neupane, Timothy J. O’Donnell, Jasmine S. Paula, Laura M. Sanchez, Anam F. Shaikh, Sylvia Soldatou, Barbara R. Terlouw, Tuan Anh Tran, Mercia Valentine, Justin J. J. van der Hooft, Duy A. Vo, Mingxun Wang, Darryl Wilson, Katherine E. Zink, Roger G. Linington
Publikováno v:
ACS Central Science, Vol 5, Iss 11, Pp 1824-1833 (2019)
Externí odkaz:
https://doaj.org/article/b59bf6e4802544868887630ad09df6bc
Autor:
Paul Kelly, Fatemeh Hadi-Nezhad, Dennis Y Liu, Travis J Lawrence, Roger G Linington, Michael Ibba, David H Ardell
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 2, p e0007983 (2020)
The development of chemotherapies against eukaryotic pathogens is especially challenging because of both the evolutionary conservation of drug targets between host and parasite, and the evolution of strain-dependent drug resistance. There is a strong
Externí odkaz:
https://doaj.org/article/2bcd2afbb04e4533845b81c890cb991e
Autor:
Aryan Houshmand, Devon Heroux, Dennis Y. Liu, Wen Zhou, Roger G. Linington, Marcel Bally, Jeffrey J. Warren, Charles J. Walsby
Publikováno v:
Dalton Transactions. 51:11437-11447
Appending of ferrocene (Fc) to biologically-active organic backbones can generate novel multi-functional species for targeting bacteria and cancer. In this work Fc was linked to coumarin and anthraquinone with the goal of harnessing the redox-active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d995b9c54b88ca983cd884b3fb986ad
https://doi.org/10.1039/d2dt01251k
https://doi.org/10.1039/d2dt01251k
Publikováno v:
Organic & Biomolecular Chemistry. 19:6291-6300
The total synthesis of the natural product coralmycin A/epi-coralmycin A, as well as a desmethoxy analogue is described. Synthesis was achieved via a divergent, bidirectional solid-phase strategy, including a key on-resin O-acylation, O to N acyl shi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::342dd9c5264d8ddd4c3cf306d493c102
https://doi.org/10.1039/d1ob01062j
https://doi.org/10.1039/d1ob01062j
Autor:
Paige M. E. Hawkins, David M. Hoi, Chen-Yi Cheung, Trixie Wang, Diana Quan, Vishnu Mini Sasi, Dennis Y. Liu, Roger G. Linington, Colin J. Jackson, Stefan H. Oehlers, Gregory M. Cook, Warwick J. Britton, Tim Clausen, Richard J. Payne
Publikováno v:
Journal of medicinal chemistry. 65(6)
Ohmyungsamycin A and ecumicin are structurally related cyclic depsipeptide natural products that possess activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c7407a67bac14efae151a19bc11014
https://pubmed.ncbi.nlm.nih.gov/35293761
https://pubmed.ncbi.nlm.nih.gov/35293761
Autor:
Sanghoon Lee, Jeffrey A. van Santen, Nima Farzaneh, Dennis Y. Liu, Cameron R. Pye, Tim U. H. Baumeister, Weng Ruh Wong, Roger G. Linington
Publikováno v:
ACS central science. 8(2)
Few tools exist in natural products discovery to integrate biological screening and untargeted mass spectrometry data at the library scale. Previously, we reported Compound Activity Mapping as a strategy for predicting compound bioactivity profiles d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6667357f4c502aac818218d0397c7d6
https://pubmed.ncbi.nlm.nih.gov/35233454
https://pubmed.ncbi.nlm.nih.gov/35233454
Publikováno v:
Organicbiomolecular chemistry. 19(28)
The total synthesis of the natural product coralmycin A/epi-coralmycin A, as well as a desmethoxy analogue is described. Synthesis was achieved via a divergent, bidirectional solid-phase strategy, including a key on-resin O-acylation, O to N acyl shi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::424df4d2a9d2da31d81d1fbd2ec50b14
https://pubmed.ncbi.nlm.nih.gov/34212970
https://pubmed.ncbi.nlm.nih.gov/34212970