Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Dennis Wray"'
Autor:
John Newsom-Davis, P. Shillito, J. Harrison, N. M. F. Murray, Angela Vincent, David Beeson, Peter C. M. Molenaar, Kerry R. Mills, M. Betty, Dennis Wray, Jacqueline Palace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3f93e72e92c323d015085bc2b34d03
https://ora.ox.ac.uk/objects/uuid:b50d9362-cc2c-4084-9c9f-8d1f52296526
https://ora.ox.ac.uk/objects/uuid:b50d9362-cc2c-4084-9c9f-8d1f52296526
Publikováno v:
European Biophysics Journal. 38:523-532
Ether-a-go-go potassium channels have large intracellular regions containing 'Per-Ant-Sim' (PAS) and cyclic nucleotide binding (cNBD) domains at the N- and C-termini, respectively. In heag1 and heag2 channels, recent studies have suggested that the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de443b25c9e1e6c56fedf9f7b420bb2f
https://doi.org/10.1007/s00249-009-0402-8
https://doi.org/10.1007/s00249-009-0402-8
Publikováno v:
European Biophysics Journal. 38:569-576
The functional role of the large intracellular regions (which include the cyclic nucleotide binding domain, cNBD, and the Per-Arnt-Sim domain, PAS) in the herg channel is not well understood. We have studied possible interactions of the cNBD with oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d870add7034021dd877aedbdb60c3526
https://doi.org/10.1007/s00249-009-0408-2
https://doi.org/10.1007/s00249-009-0408-2
Publikováno v:
Journal of Biological Chemistry. 281:19233-19240
The voltage-gated Kv2.1 channel is composed of four identical subunits folded around the central pore and does not inactivate appreciably during short depolarizing pulses. To study voltage-induced relative molecular rearrangements of the channel, Kv2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c0ea521dc6713c8aab2f2e5d7cccd1
https://doi.org/10.1074/jbc.m601231200
https://doi.org/10.1074/jbc.m601231200
Autor:
Kate Bracey, Dennis Wray
Publikováno v:
Voltage-Gated Ion Channels as Drug Targets, Volume 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a6aebeafb4243c2c6d4c65a8d4f7091
https://doi.org/10.1002/3527608141.ch8a
https://doi.org/10.1002/3527608141.ch8a
Autor:
Dennis Wray, D. J. Gawler, Hugh A. Pearson, V A Porter, Nigel Hodson, Carol J. Milligan, Lin-Hua Jiang
Publikováno v:
Journal of Biological Chemistry. 275:6135-6143
We have studied the effect of 8-bromo-cyclic GMP (8-Br-cGMP) on cloned cardiac L-type calcium channel currents to determine the site and mechanism of action underlying the functional effect. Rabbit cardiac alpha(1C) subunit, in the presence or absenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fac391ffe3ee902a02ff33fb6d2d36
https://doi.org/10.1074/jbc.275.9.6135
https://doi.org/10.1074/jbc.275.9.6135
Publikováno v:
The Journal of Physiology. 521:315-326
1. The gating properties of voltage-gated potassium channels are largely determined by the amino acid sequence of their S4 segments. To investigate the nature of S4 movement during gating, we introduced single cysteines into the S4 segment of the Sha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903fdae34a944960eda83b15ab32ee26
https://doi.org/10.1111/j.1469-7793.1999.00315.x
https://doi.org/10.1111/j.1469-7793.1999.00315.x
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 438:868-878
The inwardly rectifying potassium channel Kir2.3 possesses extracellular cysteine residues at positions 113, 140, and 145, as well as at position 79 near the outer membrane boundary. In this study, we have investigated the roles of these extracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d44a400afb53e1c8b6c330511636dec
https://doi.org/10.1007/s004249900126
https://doi.org/10.1007/s004249900126
Autor:
Michaela Berger, Robert Bähring, Karl Peter Giese, Alcino J. Silva, Thorsten Leicher, Olaf Pongs, Johan F. Storm, Jochen Roeper, Dennis Wray
Publikováno v:
King's College London
Voltage-gated potassium channels (Kv) of the Shaker-related superfamily are assembled from membrane-integrated alpha subunits and auxiliary beta subunits. The beta subunits may increase Kv channel surface expression and/or confer A-type behavior to n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0feb5859101c45512bdd4a6a2c04a9
https://doi.org/10.1111/j.1749-6632.1999.tb11296.x
https://doi.org/10.1111/j.1749-6632.1999.tb11296.x
Publikováno v:
Molecular Membrane Biology. 13:53-60
A simple and rapid protein chemical approach for determining the transmembrane structure of membrane proteins is described. The method involves single substitutions of consecutive amino acid residues, within putative transmembrane segments, to cystei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1558b9dab7662b19b140f8ebfbb01196
https://doi.org/10.3109/09687689609160575
https://doi.org/10.3109/09687689609160575