Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Dennis W Juma"'
Autor:
Dennis W Juma, Peninah Muiruri, Krista Yuhas, Grace John-Stewart, Ronald Ottichilo, John Waitumbi, Benson Singa, Christina Polyak, Edwin Kamau
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e0007223 (2019)
OBJECTIVE:Cotrimoxazole prevents opportunistic infections including falciparum malaria in HIV-infected individuals but there are concerns of cross-resistance to other antifolate drugs such as sulphadoxine-pyrimethamine (SP). In this study, we investi
Externí odkaz:
https://doaj.org/article/40f3c777295744a4b355e4b10584edba
Autor:
Reagan M Mogire, Hoseah M Akala, Rosaline W Macharia, Dennis W Juma, Agnes C Cheruiyot, Ben Andagalu, Mathew L Brown, Hany A El-Shemy, Steven G Nyanjom
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186364 (2017)
Malaria causes about half a million deaths annually, with Plasmodium falciparum being responsible for 90% of all the cases. Recent reports on artemisinin resistance in Southeast Asia warrant urgent discovery of novel drugs for the treatment of malari
Externí odkaz:
https://doaj.org/article/bc5a78fc4ecc46e3a76e2e60ee241e49
Autor:
Lorna J Chebon, Bidii S Ngalah, Luicer A Ingasia, Dennis W Juma, Peninah Muiruri, Jelagat Cheruiyot, Benjamin Opot, Emmanuel Mbuba, Mabel Imbuga, Hoseah M Akala, Wallace Bulimo, Ben Andagalu, Edwin Kamau
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162524 (2016)
Genetically determined artemisinin resistance in Plasmodium falciparum has been described in Southeast Asia. The relevance of recently described Kelch 13-propeller mutations for artemisinin resistance in Sub-Saharan Africa parasites is still unknown.
Externí odkaz:
https://doaj.org/article/56009bc8fab346629c57fb18b64960bd
Autor:
Reagan M. Mogire, Silviane A. Miruka, Dennis W. Juma, Case W. McNamara, Ben Andagalu, Jeremy N. Burrows, Elodie Chenu, James Duffy, Bernhards R. Ogutu, Hoseah M. Akala
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Drug discovery is an intricate and costly process. Repurposing existing drugs and active compounds offers a viable pathway to develop new therapies for various diseases. By leveraging publicly available biomedical information, it is possible
Externí odkaz:
https://doaj.org/article/9abd7be432b44ac9ad401606323a2e80
Autor:
Gladys C. Chemwor, Ben M. Andagalu, Irene A. Onyango, Benjamin H. Opot, Raphael O. Okoth, Redemptah A. Yedah, Jackline A. Juma, Edwin W. Mwakio, Dancan M. Wakoli, Joseph G. Amwoma, Agnes C. Cheruiyot, Dennis W. Juma, Bernhards R. Ogutu, Timothy E. Egbo, Eric C. Garges, Amanda L. Roth, Edwin Kamau, Oliver J. Watson, Hoseah M. Akala
Publikováno v:
International Journal of Infectious Diseases, Vol 132, Iss , Pp 17-25 (2023)
Objectives: This study examined the treatment response of mixed vs single-species Plasmodium falciparum infections to artemisinin-based combination therapies (ACTs). Methods: A total of 1211 blood samples collected on days 0, 7, 14, 21, 28, 35, and 4
Externí odkaz:
https://doaj.org/article/d19083ff7cf44a0d9b137282179c1b84
Autor:
Jackson M. Muema, James M. Mutunga, Meshack A. Obonyo, Merid N. Getahun, Ramadhan S. Mwakubambanya, Hoseah M. Akala, Agnes C. Cheruiyot, Redemptah A. Yeda, Dennis W. Juma, Ben Andagalu, Jaree L. Johnson, Amanda L. Roth, Joel L. Bargul
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background The unmet demand for effective malaria transmission-blocking agents targeting the transmissible stages of Plasmodium necessitates intensive discovery efforts. In this study, a bioactive bisbenzylisoquinoline (BBIQ), isoliensinine,
Externí odkaz:
https://doaj.org/article/be6482cc39094cfb87687c85f9ebef5d
Autor:
Ben Andagalu, Pinyi Lu, Irene Onyango, Elke Bergmann-Leitner, Ruth Wasuna, Geoffrey Odhiambo, Lorna J. Chebon-Bore, Luicer A. Ingasia, Dennis W. Juma, Benjamin Opot, Agnes Cheruiyot, Redemptah Yeda, Charles Okudo, Raphael Okoth, Gladys Chemwor, Joseph Campo, Anders Wallqvist, Hoseah M. Akala, Daniel Ochiel, Bernhards Ogutu, Sidhartha Chaudhury, Edwin Kamau
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
The impact of pre-existing immunity on the efficacy of artemisinin combination therapy is largely unknown. We performed in-depth profiling of serological responses in a therapeutic efficacy study [comparing artesunate-mefloquine (ASMQ) and artemether
Externí odkaz:
https://doaj.org/article/8860f475c2f14a1a9ac4fc3bf97ccf77
Autor:
Douglas O. Ochora, Esezah K. Kakudidi, Jane Namukobe, Perpetua Ipulet, Dancan M. Wakoli, Winnie Okore, Edwin W. Mwakio, Redempthah A. Yeda, Agnes C. Cheruiyot, Dennis W. Juma, Ben Andagalu, Amanda L. Roth, Bernhards R. Ogutu, Abiy Yenesew, Hoseah M. Akala
Publikováno v:
Plants, Vol 11, Iss 1, p 47 (2021)
Malaria is the most lethal parasitic disease in the world. The frequent emergence of resistance by malaria parasites to any drug is the hallmark of sustained malaria burden. Since the deployment of artemisinin-based combination therapies (ACTs) it is
Externí odkaz:
https://doaj.org/article/27b43c3627354952ad059357c663a37f
Autor:
Angela O. Achieng, Peninah Muiruri, Luicer A. Ingasia, Benjamin H. Opot, Dennis W. Juma, Redemptah Yeda, Bidii S. Ngalah, Bernhards R. Ogutu, Ben Andagalu, Hoseah M. Akala, Edwin Kamau
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 92-99 (2015)
Artemether–lumefantrine (AL) became the first-line treatment for uncomplicated malaria in Kenya in 2006. Studies have shown AL selects for SNPs in pfcrt and pfmdr1 genes in recurring parasites compared to the baseline infections. The genotypes asso
Externí odkaz:
https://doaj.org/article/abbbeff2eee247d5bab114bd5d409723
Autor:
Agnes C. Cheruiyot, Kenneth K Mitei, Bernhards Ogutu, Edwin Kamau, Ben Andagalu, Redemptah Yeda, Robert Verity, Raphael Okoth, Edwin W. Mwakio, Jim Ray Managbanag, Luicer Anne Olubayo Ingasia, Charles O. Okello, Hoseah M. Akala, Jackline A. Juma, Oliver J Watson, Nicholas F Brazeau, Maureen N. Maraka, David P. Kateete, Dennis W. Juma, Gladys C. Chemwor, Benjamin Opot
Publikováno v:
The Lancet Microbe. 2:e141-e150
Summary Background The epidemiology and severity of non-falciparum malaria in endemic settings has garnered little attention. We aimed to characterise the prevalence, interaction, clinical risk factors, and temporal trends of non-falciparum Plasmodiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ad5f5e7d9711ea2ca1d78064665fd60
https://doi.org/10.1016/s2666-5247(21)00009-4
https://doi.org/10.1016/s2666-5247(21)00009-4