Zobrazeno 1 - 10
of 1 574
pro vyhledávání: '"Dennis W Dickson"'
Autor:
Paula Castellanos Otero, Tiffany W Todd, Wei Shao, Caroline J Jones, Kexin Huang, Lillian M Daughrity, Mei Yue, Udit Sheth, Tania F Gendron, Mercedes Prudencio, Björn Oskarsson, Dennis W Dickson, Leonard Petrucelli, Yong-Jie Zhang
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0298080 (2024)
Inclusions containing TAR DNA binding protein 43 (TDP-43) are a pathological hallmark of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). One of the disease-specific features of TDP-43 inclusions is the aberrant phosphorylation
Externí odkaz:
https://doaj.org/article/8a84232f980c4c2ab3c974b7c2363957
Autor:
Yuka Koike, Sarah Pickles, Virginia Estades Ayuso, Karen Jansen-West, Yue A Qi, Ziyi Li, Lillian M Daughrity, Mei Yue, Yong-Jie Zhang, Casey N Cook, Dennis W Dickson, Michael Ward, Leonard Petrucelli, Mercedes Prudencio
Publikováno v:
PLoS Biology, Vol 21, Iss 3, p e3002028 (2023)
A major function of TAR DNA-binding protein-43 (TDP-43) is to repress the inclusion of cryptic exons during RNA splicing. One of these cryptic exons is in UNC13A, a genetic risk factor for amyotrophic lateral sclerosis (ALS) and frontotemporal dement
Externí odkaz:
https://doaj.org/article/c620da5c535e493fbf35161ed1b10532
Publikováno v:
Free Neuropathology, Vol 1 (2020)
Background: The majority of cases of frontotemporal lobar degeneration (FTLD) are characterized by focal cortical atrophy with an underlying tau or TDP-43 proteinopathy. A subset of FTLD cases, however, lack tau and TDP-43 immunoreactivity, but have
Externí odkaz:
https://doaj.org/article/b1053bf272a349769d3e5604473f566c
Autor:
Olivia J Conway, Minerva M Carrasquillo, Xue Wang, Jenny M Bredenberg, Joseph S Reddy, Samantha L Strickland, Curtis S Younkin, Jeremy D Burgess, Mariet Allen, Sarah J Lincoln, Thuy Nguyen, Kimberly G Malphrus, Alexandra I Soto, Ronald L Walton, Bradley F Boeve, Ronald C Petersen, John A Lucas, Tanis J Ferman, William P Cheshire, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, Neill R Graff-Radford, Nilüfer Ertekin-Taner
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background Rare coding variants ABI3_rs616338-T and PLCG2_rs72824905-G were identified as risk or protective factors, respectively, for Alzheimer’s disease (AD). Methods We tested the association of these variants with five neurodegenerati
Externí odkaz:
https://doaj.org/article/26aae77c26cb4a6c9e381ff00070adea
Autor:
Agnieszka Ciesielska, Lluis Samaranch, Waldy San Sebastian, Dennis W Dickson, Samuel Goldman, John Forsayeth, Krystof S Bankiewicz
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0169965 (2017)
In Parkinson's disease (PD), aromatic L-amino acid decarboxylase (AADC) is the rate-limiting enzyme in the conversion of L-DOPA (Sinemet) to dopamine (DA). Previous studies in PD animal models demonstrated that lesion of dopaminergic neurons is assoc
Externí odkaz:
https://doaj.org/article/ea75beb4441043c3b6b8c31c4b570fb2
Autor:
Kasey L Jackson, Wen-Lang Lin, Sumitra Miriyala, Robert D Dayton, Manikandan Panchatcharam, Kevin J McCarthy, Monica Castanedes-Casey, Dennis W Dickson, Ronald L Klein
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169291 (2017)
One of the proteins most frequently found in neuropathological lesions is the ubiquitin binding protein p62 (sequestosome 1). Post-mortem analysis of p62 is a defining diagnostic marker in several neurodegenerative diseases including amyotrophic late
Externí odkaz:
https://doaj.org/article/3dee2022fb8c45f6b60958ecc55492be
Autor:
Catherine Labbé, Kotaro Ogaki, Oswaldo Lorenzo-Betancor, Minerva M Carrasquillo, Michael G Heckman, Allan McCarthy, Alexandra I Soto-Ortolaza, Ronald L Walton, Timothy Lynch, Joanna Siuda, Grzegorz Opala, Anna Krygowska-Wajs, Maria Barcikowska, Krzysztof Czyzewski, Dennis W Dickson, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128586 (2015)
Genome-wide association studies (GWAS) in Parkinson's disease (PD) have identified over 20 genomic regions associated with disease risk. Many of these loci include several candidate genes making it difficult to pinpoint the causal gene. The locus on
Externí odkaz:
https://doaj.org/article/aa2f264e4c774cc6bbd495cb2c0ff877
Autor:
Cindy Zehr, Jada Lewis, Eileen McGowan, Julia Crook, Wen-Lang Lin, Kate Godwin, Joshua Knight, Dennis W Dickson, Mike Hutton
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 3, Pp 553-562 (2004)
Transgenic mice overexpressing human tau with the P301L mutation develop neurofibrillary tangles, extensive gliosis, adult-onset motor abnormalities, and neuronal loss in affected brain regions. We investigated the mechanism of neuronal cell death in
Externí odkaz:
https://doaj.org/article/4ef6b8dafab54eb48ed6eb9b88fb1212
Publikováno v:
Neurobiology of Disease, Vol 14, Iss 2, Pp 251-264 (2003)
Pin1, a peptidyl-prolyl isomerase binds to mitotic serine or threonine phosphoproteins. In Alzheimer's disease (AD) evidence points to the reactivation of mitosis in vulnerable neurons. Tangles composed of hyperphosphorylated tau contain phosphorylat
Externí odkaz:
https://doaj.org/article/c76b6c26a2e7470d9402fdf66ad2d9a6
Autor:
Gary W Beecham, Kara Hamilton, Adam C Naj, Eden R Martin, Matt Huentelman, Amanda J Myers, Jason J Corneveaux, John Hardy, Jean-Paul Vonsattel, Steven G Younkin, David A Bennett, Philip L De Jager, Eric B Larson, Paul K Crane, M Ilyas Kamboh, Julia K Kofler, Deborah C Mash, Linda Duque, John R Gilbert, Harry Gwirtsman, Joseph D Buxbaum, Patricia Kramer, Dennis W Dickson, Lindsay A Farrer, Matthew P Frosch, Bernardino Ghetti, Jonathan L Haines, Bradley T Hyman, Walter A Kukull, Richard P Mayeux, Margaret A Pericak-Vance, Julie A Schneider, John Q Trojanowski, Eric M Reiman, Alzheimer's Disease Genetics Consortium (ADGC), Gerard D Schellenberg, Thomas J Montine
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004606 (2014)
Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association study and analysis of kno
Externí odkaz:
https://doaj.org/article/16fab959c9274eda9e554f003340125a