Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Dennis W Choi"'
Autor:
Lorella M.T Canzoniero, Debra J Babcock, Frank J Gottron, Margaret C Grabb, Pat Manzerra, B.Joy Snider, Dennis W Choi
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 3, Pp 520-528 (2004)
The relationship between intracellular Ca2+ ([Ca2+]i) regulation and programmed cell death is not well-defined; both increases and decreases in [Ca2+]i have been observed in cells undergoing apoptosis. We determined [Ca2+]i in cultured murine cortica
Externí odkaz:
https://doaj.org/article/358f94242cfc4b32b4f085b383315533
Autor:
Hyun-Jung Kim, Jung Jin Hwang, M.Margarita Behrens, B.Joy Snider, Dennis W Choi, Jae-Young Koh
Publikováno v:
Neurobiology of Disease, Vol 14, Iss 1, Pp 110-119 (2003)
In the present study, the signaling mechanisms underlying the effect of brain-derived neurotrophic factor (BDNF) on neuronal necrosis were investigated. Exposure of mature mouse cortical cultures (more than 10 days in vitro (DIV)) to 50–100 ng/ml B
Externí odkaz:
https://doaj.org/article/0a5b03d139c24719b29a6199dec5eb1a
Autor:
Lorella M.T. Canzoniero, Alberto eGranzotto, Dorothy M Turetsky, Dennis W Choi, Laura L Dugan, Stefano L Sensi
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Hungtinton’s disease (HD) is a neurodegenerative condition characterized by severe neuronal loss in the cortex and striatum that leads to motor and behavioral deficits. Excitotoxicity is thought to be involved in HD and several studies have indicat
Externí odkaz:
https://doaj.org/article/c815d13f9e5a4947a68aad4db6a6b584
Autor:
Jin Soo Lee, Ji Sung Lee, Byoung Joo Gwag, Dennis W. Choi, Chun San An, Hyun Goo Kang, Tae-Jin Song, Seong Hwan Ahn, Chang Hun Kim, Dong-Ick Shin, Sun U. Kwon
Publikováno v:
Journal of Stroke, Vol 25, Iss 1, Pp 160-168 (2023)
Background and Purpose Nelonemdaz (Neu2000) has both selective antagonism against 2B subunit of N-methyl-D-aspartate receptor and antioxidant activity. This drug provides sufficient evidence of neuroprotection in acute cerebral ischemia/reperfusion m
Externí odkaz:
https://doaj.org/article/a097a12398f447f6bc989b7fdc4a1d66
Publikováno v:
BMC Neurology, Vol 20, Iss 1, Pp 1-6 (2020)
Abstract Background The blood-brain barrier has been a hindrance to developing blood-based diagnostic tests for dementias, as it limits the appearance of brain biomarkers in the blood. Our aim was to see if the natural opening of the blood-brain barr
Externí odkaz:
https://doaj.org/article/1948521baea540928a6b909331590dfe
Autor:
Ji Man Hong, Jin Soo Lee, Yeong-Bae Lee, Dong Hoon Shin, Dong-Ick Shin, Yang-Ha Hwang, Seong Hwan Ahn, Jae Guk Kim, Sung-Il Sohn, Sun U. Kwon, Ji Sung Lee, Byoung Joo Gwag, Ángel Chamorro, Dennis W. Choi, Ángel Chammorro, Eung Yeop Kim, Jin Wook Choi, Min-Ju Yeo, Jaehyuk Kwak, Sung Eun Lee, Jeong-Ho Hong, Sangkil Lee, Yoon-Joo Lee, Min-Joo Lee
Publikováno v:
Stroke. 53:3250-3259
Background: Nelonemdaz is a multitarget neuroprotectant that selectively blocks N-methyl-D-aspartate receptors and scavenges free radicals, as proven in preclinical ischemia-reperfusion studies. We aimed to evaluate the safety and efficacy of nelonem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22eac512f43e517de28ebdc802ef09dd
https://doi.org/10.1161/strokeaha.122.039649
https://doi.org/10.1161/strokeaha.122.039649
Autor:
Jin Soo Lee, Ji Sung Lee, Byoung Joo Gwag, Dennis W Choi, Chun San An, Hyun Goo Kang, Tae-Jin Song, Seong Hwan Ahn, Chang Hun Kim, Sun U Kwon
Publikováno v:
Stroke. 54
Background: A phase III Rescue On reperfusion Damage in cerebral Infarction by Nelonemdaz (RODIN) trial has been launched since December, 2021 and patients are being enrolled. Rationale: Nelonemdaz (previously, neu2000) targets (1) selectively the 2B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::464e41a76a3e63c9f1bc0599b35b6e12
https://doi.org/10.1161/str.54.suppl_1.tp15
https://doi.org/10.1161/str.54.suppl_1.tp15
Publikováno v:
BMC Neurology, Vol 20, Iss 1, Pp 1-6 (2020)
BMC Neurology
BMC Neurology
BackgroundThe blood-brain barrier has been a hindrance to developing blood-based diagnostic tests for dementias, as it limits the appearance of brain biomarkers in the blood. Our aim was to see if the natural opening of the blood-brain barrier induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde2ad0be00de63128d76598261bc1db
http://link.springer.com/article/10.1186/s12883-020-01859-1
http://link.springer.com/article/10.1186/s12883-020-01859-1
Autor:
Dennis W. Choi
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience, Vol 14 (2020)
Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate (NMDA) antagonists in high profile clinical stroke trials. Nonetheles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc3134918c8b73b84102dd32178fc89
http://europepmc.org/articles/PMC7649323
http://europepmc.org/articles/PMC7649323
Autor:
Joel A. Kovoor, Yu H. Zhong, Wei X. Zhang, Jasbeer Dhawan, Anat Biegon, John Sullivan, Dennis W. Choi
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 174:225-233
Accumulating evidence suggests that expression of aromatase, the enzyme responsible for the conversion of androgens to estrogens, is transiently upregulated in rat stroke models. It was further suggested that increased aromatase expression is linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e6dad4850e27594be620ec28eebe14
https://doi.org/10.1016/j.jsbmb.2017.09.019
https://doi.org/10.1016/j.jsbmb.2017.09.019