Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dennis V. Nazareno"'
Autor:
Marc A. Labroli, Geoffrey B. Varty, Dennis V. Nazareno, Stuart W. McCombie, Steensma Ruo, Julie M. Strizki, Bahige M. Baroudy, Jayaram R. Tagat, Kathleen Cox, Robert W. Watkins, Jean E. Lachowicz, Yushi Xiao
Publikováno v:
Journal of Medicinal Chemistry. 47:2405-2408
The nature and the size of the benzylic substituent are shown to be the key to controlling receptor selectivity (CCR5 vs M1, M2) and potency in the title compounds. Optimization of the lead benzylic methyl compound 3 led to the methoxymethyl analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2f7d87ed1298266b41ff938e8e90d6
https://doi.org/10.1021/jm0304515
https://doi.org/10.1021/jm0304515
Autor:
Michael G. Murray, Bernard R. Neustadt, Julie M. Strizki, Sue-Ing Lin, Nicole Vantuno, Lisa Wojcik, Jayaram R. Tagat, Kathleen Cox, and Bahige M. Baroudy, Steensma Ruo, Dennis V. Nazareno, Stuart W. McCombie, Serena Xu
Publikováno v:
Journal of Medicinal Chemistry. 44:3343-3346
Truncation of the original piperidino-2(S)-methyl piperazine lead structure 2, from a family of muscarinic antagonists, gave compound 8 which has improved selectivity for the HIV-1 co-receptor CCR5 over muscarinic receptors. Further optimization for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d3fd3d509d230c7eb1b4a8a60a7827
https://doi.org/10.1021/jm0155401
https://doi.org/10.1021/jm0155401
Autor:
Dennis V. Nazareno, Guowei Zhou, Herbert Binch, William J. Greenlee, Mary Cohen-Williams, Jayaram R. Tagat, Diane E. Grotz, Jean E. Lachowicz, James J. Kaminski, Joseph A. Kozlowski, Gordon Crosby, Stuart W. McCombie, Vicki L. Coffin, Kathleen Cox, Vilma Ruperto, Craig D. Boyle, Samuel Chackalamannil, Ruth A. Duffy, Hubert B. Josien, Yuguang Wang, John W. Clader, William Billard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2311-2314
The potential toxicological liabilities of the M(2) muscarinic antagonist 1 were addressed by replacing the methylenedioxyphenyl moiety with a p-methoxyphenyl group, resulting in M(2) selective compounds such as 3. Several halogenated naphthamide der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4596ee0f6758218aaf4305ca38b8523f
https://doi.org/10.1016/s0960-894x(01)00435-8
https://doi.org/10.1016/s0960-894x(01)00435-8
Autor:
Dennis V. Nazareno, Stuart W. McCombie, Bahige M. Baroudy, Jayaram R. Tagat, Steensma Ruo, Serena Xu, Sue-Ing Lin, Nicole Vantuno, Jia Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2143-2146
Optimization of the piperidino-piperazines 1 and 2 provided early leads 3 and 4, which showed good activity in the CCR5–RANTES binding assay and in antiviral assays. A systematic study around these structures showed that the 2(S)-methyl piperazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa9f48d8d60af12dd8a81e32c5ce804
https://doi.org/10.1016/s0960-894x(01)00381-x
https://doi.org/10.1016/s0960-894x(01)00381-x
Autor:
Thomas A. Bara, Hubert B. Josien, Anandan Palani, Stuart W. McCombie, Dennis V. Nazareno, Annette Bauer, Jennifer Ford, Vice Susan F, Jayaram R. Tagat, Michael W. Miller, C A Evans
Publikováno v:
The Journal of Organic Chemistry. 66:2487-2492
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79aed5aac8c1cfe75c181cb67a029294
https://doi.org/10.1021/jo0007682
https://doi.org/10.1021/jo0007682
Autor:
Beverly E. Barton, Stuart W. McCombie, Jayaram R. Tagat, Jennifer Shortall, Dennis V. Nazareno, James V. Jackson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2139-2142
A versatile synthetic route to the title class of compounds and the development of an orally absorbed analogue of the lead structure are described. The minimum structural requirements needed in the compounds related to 1 for the inhibition of interle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce0fbf79a57ec89871b2a6c6916ea0b4
https://doi.org/10.1016/0960-894x(95)00362-w
https://doi.org/10.1016/0960-894x(95)00362-w
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1101-1104
Dehydroabietic acid 5 was converted to the exocyclic olefin 7 by applying the Barton decarboxylation protocol. The latter served as key intermediate for the stereoselective synthesis of a variety of ring-A functionalized derivatives. Compounds 13 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::509e97d1656979a18c5772699e4a571c
https://doi.org/10.1016/s0960-894x(01)80236-5
https://doi.org/10.1016/s0960-894x(01)80236-5
Autor:
Dennis V. Nazareno, Stuart W. McCombie, Bandarpalle B. Shankar, William A. Metz, Jayaram R. Tagat
Publikováno v:
ChemInform. 22
Treatment of 2-[(dimethylamino) methylene]-3-oxobutanoates 9 or 10 with LiN(SiMe 3 ) 2 in the presence of RCOCl results in C-acylation. The resulting intermediate, without isolation, may be converted to 6-R-3-Carbethoxy-4-pyrones (e.g., 12) by H 3 O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa60e90787d02a7ecd65a6ed47ff836
https://doi.org/10.1002/chin.199152206
https://doi.org/10.1002/chin.199152206
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33c2f2b6a098bf95b0d6e44331cc2a1f
https://doi.org/10.1002/chin.199401310
https://doi.org/10.1002/chin.199401310
Autor:
Sue-Ing Lin, Dennis V. Nazareno, Jia Liu, Serena Xu, Jayaram R. Tagat, Nicole Vantuno, Steensma Ruo, Bahige M. Baroudy, Stuart W. McCombie
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a85e6cebc20c17cb4949e2bea0e9dd1
https://doi.org/10.1002/chin.200145175
https://doi.org/10.1002/chin.200145175