Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dennis T. Takata"'
Autor:
Kristin K. Brown, Jack D. Leber, Sharad K. Verma, Shu-Yun Zhang, Hong Lin, Brian Donovan, Mei Li, Dirk A. Heerding, Elisabeth A. Minthorn, Louis V. LaFrance, Kimberly A. Robell, Barry S. Brown, Juan I. Luengo, Igor G. Safonov, Wenyong Wang, Dennis S. Yamashita, Michael D. Schaber, Dennis T. Takata, Dana S. Levy, Jason A. Kahana, Joseph W. Venslavsky, Jin Zeng, Rakesh Kumar, Ren Xie, Anthony E. Choudhry, Zhihong Lai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:684-688
The synthesis and evaluation of tetrasubstituted aminopyridines, bearing novel azaindazole hinge binders, as potent AKT inhibitors are described. Compound 14c was identified as a potent AKT inhibitor that demonstrated reduced CYP450 inhibition and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35f1d03a41bbaae3c90655ee77ea89d
https://doi.org/10.1016/j.bmcl.2009.11.061
https://doi.org/10.1016/j.bmcl.2009.11.061
Autor:
Kevin L. Salyers, James Samanen, R. Curtis Haltiwanger, M.W. Lark, Leonard M. Azzarano, Irene N. Uzinskas, Karl F. Erhard, Robert N. Willette, Kyung O. Johanson, Catherine J. Gress, Stephen T Ross, Tian Li Yue, Keith W. Ward, William F. Huffman, Russell D. Cousins, Dirk A. Heerding, David J. Rieman, Shing Mei Hwang, Chet Kwon, Brian R. Smith, Ian E. James, William H. Miller, Catherine C.K. Yuan, Dennis T. Takata, Manley Peter J
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1483-1486
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b020a8d8d76827308cf4beb670e93f46
https://doi.org/10.1016/s0960-894x(03)00102-1
https://doi.org/10.1016/s0960-894x(03)00102-1
Autor:
William H. Miller, Catherine C.K. Yuan, Kalindi Vaidya, Brian J. Polizzi, Dennis T. Takata, Rebecca Claire Greenwood, Dirk A. Heerding, Mark A. Seefeld, Scott B. Winram, Valerie Berry, Martha S. Head, Walter J. Burgess, Andrew P. Fosberry, Nicola G. Wallis, David J. Payne, Stephen Rittenhouse, William F. Huffman, Paul M. Keller, Kevin L. Salyers, Manley Peter J, Kenneth A. Newlander, Deborah Dee Jaworski, Courtney Slater-Radosti, Cheryl A. Janson, Walter E. DeWolf, Irene N. Uzinskas, John Brosky, Stewart C. Pearson, Xiayang Qiu, Emile Chen, Terrance D. Moore, Martin G. Smyth
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:3118-3124
Bacterial enoyl-acyl carrier protein (ACP) reductase (FabI) catalyzes the final step in each elongation cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. High-throughput screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997a68e3d46cb5b0dd9196003827969e
https://doi.org/10.1128/aac.46.10.3118-3124.2002
https://doi.org/10.1128/aac.46.10.3118-3124.2002
Autor:
Dirk A. Heerding, Walter E. DeWolf, Stephen Rittenhouse, William H. Miller, Kalindi Vaidya, Catherine C.K. Yuan, Xiayang Qiu, Dennis T. Takata, Courtney Slater-Radosti, Cheryl A. Janson, Ward W. Smith, Andrew P. Fosberry, Terrance D. Moore, Edward McManus, William F. Huffman, Deborah Dee Jaworski, David J. Payne, George M. Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2061-2065
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20efabd918b21cc79658ea765378efca
https://doi.org/10.1016/s0960-894x(01)00404-8
https://doi.org/10.1016/s0960-894x(01)00404-8
Autor:
Richard M. Keenan, Steven T. Ross, M. Amparo Lago, S M Hwang, Eliot H. Ohlstein, Tian-Li Yue, David J. Rieman, Chet Kwon, Fadia E. Ali, Brian R. Smith, Lynne Vickery, Thomas T. Nguyen, Dalia R. Jakas, Russell D. Cousins, Calvert Louden, Jeffrey M. Stadel, Leon B. Hall, James Samanen, William H. Miller, Catherine C.K. Yuan, Dennis T. Takata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3171-3176
In the 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists, a compound containing an imidazopyridine arginine mimetic was discovered which had sufficient potency and i.v. pharmacokinetics for demonstrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd994a9ec637d9aef7d70da2654228e
https://doi.org/10.1016/s0960-894x(98)00556-3
https://doi.org/10.1016/s0960-894x(98)00556-3
Autor:
Thomas W. Ku, Dalia R. Jakas, William H. Miller, Valerie A. Reader, James F. Callahan, Catherine C.K. Yuan, Brian R. Smith, Dennis T. Takata, Raul R. Calvo, Thomas T. Nguyen, Bondinell William E, Fadia E. Ali, Russell D. Cousins, S M Hwang, Chet Kwon, Steven T. Ross, Irene N. Uzinskas, David J. Rieman, M. Amparo Lago, Richard M. Keenan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3165-3170
In a 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists containing a benzimidazole as a novel arginine mimetic, we examined the effects of benzimidazole modifications and amide substitutions on both act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fa8760f29ac2a671d601214e0654b9
https://doi.org/10.1016/s0960-894x(98)00555-1
https://doi.org/10.1016/s0960-894x(98)00555-1
Publikováno v:
Tetrahedron Letters. 39:6815-6818
We show here the first example of a ruthenium catalyzed ene-yne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to efficiently form highly substituted hexahydroisoindole ring systems on Wang resin. This approach was used to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb5a94f9c98e99f4d949c95e80170be7
https://doi.org/10.1016/s0040-4039(98)01473-7
https://doi.org/10.1016/s0040-4039(98)01473-7
Autor:
Angela S. Wong, James F. Callahan, William H. Miller, Catherine C.K. Yuan, Raul R. Calvo, Janice A. Vasko-Moser, Thomas W. Ku, Richard E. Valocik, Dennis T. Takata, Richard M. Keenan, Drake S. Eggleston, Michael F. Parker, Southall Linda Sue, S M Hwang, Paul F. Koster, William F. Huffman, Tobias Oregon Yellin, Chet Kwon, Irene N. Uzinskas, Bondinell William E, Fadia E. Ali, Dalia R. Jakas, Andrew J. Nichols, James Samanen, R. Curtis Haltiwanger, Kenneth A. Newlander
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2481-2486
In an investigation of the contribution of N-1 to the binding, antiaggregatory, and oral activity in 3-oxo-1,4-benzodiazepine-2-acetic acid based GPIIb/IIIa antagonists, a series of 2-benzazepine analogs, wherein N-1 of the 1,4-benzodiazepine nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ef79983c86eb17cdad500249ba3114f
https://doi.org/10.1016/0960-894x(96)00432-5
https://doi.org/10.1016/0960-894x(96)00432-5
Autor:
Kenneth A. Newlander, Chet Kwon, William F. Huffman, Richard M. Keenan, Leon B. Hall, James Samanen, Chuan-Kui Yuan, T. W. Ku, William E. Bondinell, F. E. Ali, Karl F. Erhard, Raul R. Calvo, William H. Miller, Larry D. Davis, Dennis T. Takata, Stephen T. Ross
Publikováno v:
Tetrahedron Letters. 36:9433-9436
An enantiospecific synthesis of SB 214857, a potent, nonpeplide fibrinogen receptor antagonist, is reported. The synthetic route employs as a key step an intramolecular aryl fluoride displacement to form the sevenmembered ring of the 1,4-benzodiazepi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e020141c650769ae0d556a7deb7f5124
https://doi.org/10.1016/0040-4039(95)02054-3
https://doi.org/10.1016/0040-4039(95)02054-3
Autor:
David J. Holmes, Joseph W. Venslavsky, Lisa T. Christmann, Dennis T. Takata, Tammy J. Clark, Stephen Rittenhouse, Dirk A. Heerding
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3771-3773
A novel benzylidenethiazolidinedione has been discovered with antimicrobial activity. Here, we present the results of a structure-activity study on this compound with respect to its antimicrobial activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d61badd0f9fe2e3682fde4aad29d2d
https://doi.org/10.1016/j.bmcl.2003.07.010
https://doi.org/10.1016/j.bmcl.2003.07.010