Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dennis Synetos"'
Publikováno v:
Biochimie. 90:908-917
Two mutations in the A-site of 18S rRNA of Saccharomyces cerevisiae were investigated. The first, A1491G (rdn15), creates in yeast the same C1409-G1491 base pair as in Escherichia coli and has behaved as an antisuppressor in genetic studies. Ribosome
Publikováno v:
Molecular Microbiology. 59:1651-1663
The ribosome is a macromolecular machine responsible for protein synthesis in all organisms. Despite the enormous progress in studies on the structure and function of prokaryotic ribosomes, the respective molecular details of the mechanism by which t
Publikováno v:
Journal of Biological Chemistry. 278:3314-3322
Yeast ribosomal protein L41 is dispensable in the yeast. Its absence had no effect on polyphenylalanine synthesis activity, and a limited effect on growth, translational accuracy, or the resistance toward the antibiotic paromomycin. Removal of L41 di
Publikováno v:
Biochemistry. 40:8101-8108
The major function of the ribosome is its ability to catalyze formation of peptide bonds, and it is carried out by the ribosomal peptidyltransferase. Recent evidence suggests that the catalyst of peptide bond formation is the 23S rRNA of the large ri
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1309:156-166
Ribosomal proteins S 12, S5 and S4 of Escherichia coli are essential for the control of translational accuracy. Their yeast equivalents, i.e., S28, S4 and S13, have also been implicated in this process. Using a poly(U)-dependent cell-free translation
Publikováno v:
Journal of Autonomic Pharmacology. 11:343-351
1. The biological activity of a plasma-derived, clonidine displacing substance (CDS)-like material was tested on isolated rat aortic rings and compared to that of clonidine, an imidazoline with alpha 2-adrenoceptor agonist properties. 2. The CDS-like
Autor:
Dennis Synetos, Panagiotis Panopoulos, Theodoros C. Konstantinidis, John Dresios, Smaragdi Tselika
Publikováno v:
The FASEB Journal. 21
Publikováno v:
Biochemistry. 45(11)
The function of mutations rdn1A, rdn1T, and rdn2 in 18S rRNA of Saccharomyces cerevisiae is investigated. The mutations correspond to substitutions C1054A, C1054U in helix 34, and G517A in helix 18 of 16S rRNA in Escherichia coli, respectively, in wh
Publikováno v:
Nucleic acids research. 32(18)
A C→U mutation (rdn5) in the conserved sarcin/ricin domain of yeast 25S rRNA has been shown to cause translational suppression and paromomycin resistance. It also separates the killing from the misreading effect of this antibiotic. We confirm these
Publikováno v:
Biochemistry. 39(24)
Four mutant strains from Saccharomyces cerevisiae were used to study ribosome structure and function. They included a strain carrying deletions of the two genes encoding ribosomal protein L24, a strain carrying a mutation spb2 in the gene for ribosom