Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dennis Sprous"'
Publikováno v:
British Journal of Pharmacology. 153:1739-1749
Background and purpose: Thymol, a major component of thyme and oregano, has medical uses in oral care products as an astringent and antibiotic. Its distinctive sharp odour and pungent flavour are considered aversive properties. The molecular basis of
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:525-528
Fragment-based virtual library design and virtual screening have been conducted against malic enzyme (ME) homology model. Several scaffolds have been identified as promising motifs to target ME's NADP binding site. One small focused library has been
Publikováno v:
Biopolymers. 39:259-278
Small (600 base pair) DNA plasmids were modeled with a simplified representation (3DNA) and the intramolecular motions were studied using molecular mechanics and molecular dynamics techniques. The model is detailed enough to incorporate sequence effe
Publikováno v:
Biopolymers. 39:243-258
Many modeling studies of supercoiled DNA are based on equilibrium structures from theoretical calculations or energy minimization. Since closed circular DNAs are flexible, it is possible that errors are introduced by calculating properties from a sin
Publikováno v:
Combinatorial chemistryhigh throughput screening. 16(3)
Positive allosteric modulators (PAMs) of receptors represent a class of pharmacologic agents having the desirable property of acting only in the presence of cognate ligands. Discovery and optimization of the structure activity relationships of PAMs i
Autor:
Stacy Carlucci-Derbyshire, Ivona Bakaj, Rok Cerne, Rosa Y. Cortés, Zheng Zhang, M. N. Tulu Buber, S. Paul Lee, Dennis Sprous, Aaron C. Pawlyk, R. Kyle Palmer, Heather R. Devantier, Karnail S. Atwal, Vincent H. Jorgensen, Robert W. Bryant
Publikováno v:
Assay and drug development technologies. 8(6)
Transient receptor potential melastatin-5 (TRPM5) is a calcium-gated monovalent cation channel expressed in highly specialized cells of the taste bud and gastrointestinal tract, as well as in pancreatic β-cells. Well established as a critical signal
Autor:
Dennis, Sprous, Kyle R, Palmer
Publikováno v:
Progress in molecular biology and translational science. 91
Taste signaling is a critical determinant of ingestive behaviors and thereby linked to obesity and related metabolic dysfunctions. Recent evidence of taste signaling pathways in the gut suggests the link to be more direct, raising the possibility tha
Autor:
R. Kyle Palmer, Dennis Sprous
Taste signaling is a critical determinant of ingestive behaviors and thereby linked to obesity and related metabolic dysfunctions. Recent evidence of taste signaling pathways in the gut suggests the link to be more direct, raising the possibility tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fae1e1784ce0869870911cb80b1c18f
https://doi.org/10.1016/s1877-1173(10)91006-5
https://doi.org/10.1016/s1877-1173(10)91006-5
Autor:
Dennis Sprous
Publikováno v:
Journal of molecular graphicsmodelling. 27(2)
In ongoing research, QSAR has been a tool applied to evaluate compound qualities associated with skin permeability and membership in either a druglike class or specific nondruglike type classes. A need that arose from this pursuit was to know the bou
Publikováno v:
Journal of molecular graphicsmodelling. 24(4)
We have applied a retrosynthetic program to determine the scaffold and R-group chemical space seen within a library of known kinase inhibitors and nonkinase druglike molecules. Comparison of the differences quickly revealed that kinase inhibitors are