Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Dennis Sohn"'
Autor:
Judith Neuwahl, Chantal A. Neumann, Annika C. Fitz, Anica D. Biermann, Maja Magel, Annabelle Friedrich, Lorenz Sellin, Björn Stork, Roland P. Piekorz, Peter Proksch, Wilfried Budach, Reiner U. Jänicke, Dennis Sohn
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-14 (2024)
Abstract The targeted elimination of radio- or chemotherapy-induced senescent cells by so-called senolytic substances represents a promising approach to reduce tumor relapse as well as therapeutic side effects such as fibrosis. We screened an in-hous
Externí odkaz:
https://doaj.org/article/e1d558cf63a94e08b3b6bbd7624c9ad0
Autor:
Soha A. Hassan, Amira A. H. Ali, Dennis Sohn, Ulrich Flögel, Reiner U. Jänicke, Horst‐Werner Korf, Charlotte vonGall
Publikováno v:
Cancer Medicine, Vol 10, Iss 21, Pp 7712-7725 (2021)
Abstract This study investigates whether a chronotherapeutic treatment of hepatocellular carcinoma (HCC) may improve treatment efficacy and mitigate side effects on non‐tumoral liver (NTL). HCC was induced in Per2::luc mice which were irradiated at
Externí odkaz:
https://doaj.org/article/23184073e86e41f8a8664be2650268d9
Autor:
Mona Yassine, Soha A. Hassan, Simon Sommer, Lea Aylin Yücel, Hanna Bellert, Johanna Hallenberger, Dennis Sohn, Horst-Werner Korf, Charlotte von Gall, Amira A. H. Ali
Publikováno v:
Cells, Vol 12, Iss 1, p 61 (2022)
Chronic liver diseases including hepatocellular carcinoma (HCC) create a state of chronic inflammation that affects the brain via the liver–brain axis leading to an alteration of neurotransmission and cognition. However, little is known about the e
Externí odkaz:
https://doaj.org/article/6b6dfbcb07fc4d17a8c0aaaf37c873fb
Autor:
Nicolò Garbin, Alexander P. Mamunes, Dennis Sohn, Ryan W. Hawkins, Pietro Valdastri, Keith L. Obstein
Publikováno v:
Endoscopy International Open, Vol 07, Iss 09, Pp E1175-E1183 (2019)
Background and study aims Our academic lab has developed a novel, low-cost, disposable endoscope for assessment of the esophagus and stomach without need for large equipment or complex electronics. Usability and intuitiveness of the platform are unkn
Externí odkaz:
https://doaj.org/article/2d08ec648ccc42c58564032cb7c41c56
Autor:
Deborah Ingenhag, Sven Reister, Franziska Auer, Sanil Bhatia, Sarah Wildenhain, Daniel Picard, Marc Remke, Jessica I. Hoell, Andreas Kloetgen, Dennis Sohn, Reiner U. Jänicke, Gesine Koegler, Arndt Borkhardt, Julia Hauer
Publikováno v:
Haematologica, Vol 104, Iss 1 (2019)
The homeobox gene HLXB9 encodes for the transcription factor HB9, which is essential for pancreatic as well as motor neuronal development. Beside its physiological expression pattern, aberrant HB9 expression has been observed in several neoplasias. E
Externí odkaz:
https://doaj.org/article/54d17398874743d28e9bc9dfe026294a
Autor:
Laura Bergmann, Alexander Lang, Christoph Bross, Simone Altinoluk-Hambüchen, Iris Fey, Nina Overbeck, Anja Stefanski, Constanze Wiek, Andreas Kefalas, Patrick Verhülsdonk, Christian Mielke, Dennis Sohn, Kai Stühler, Helmut Hanenberg, Reiner U. Jänicke, Jürgen Scheller, Andreas S. Reichert, Mohammad Reza Ahmadian, Roland P. Piekorz
Publikováno v:
Cells, Vol 9, Iss 9, p 1950 (2020)
The stress-inducible and senescence-associated tumor suppressor SIRT4, a member of the family of mitochondrial sirtuins (SIRT3, SIRT4, and SIRT5), regulates bioenergetics and metabolism via NAD+-dependent enzymatic activities. Next to the known mitoc
Externí odkaz:
https://doaj.org/article/a6074553cc1f43e5aa630ee3f5397b69
Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors.
Autor:
Sabine Pietkiewicz, Dennis Sohn, Roland P Piekorz, Susanne Grether-Beck, Wilfried Budach, Kanaga Sabapathy, Reiner U Jänicke
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61438 (2013)
Proteasome inhibitors (PIs) potently induce apoptosis in a variety of tumor cells, but the underlying mechanisms are not fully elucidated. Comparing PI-induced apoptosis susceptibilities of various mouse embryonic fibroblast (MEF) lines differing in
Externí odkaz:
https://doaj.org/article/7537a4fb11924f6f8e7f1b98aeef1ec6
Supplementary Figure 1 from p21 Blocks Irradiation-Induced Apoptosis Downstream of Mitochondria by Inhibition of Cyclin-Dependent Kinase–Mediated Caspase-9 Activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0bc922b18c392bec8c513de8a8b226
https://doi.org/10.1158/0008-5472.22366127
https://doi.org/10.1158/0008-5472.22366127
The role of the cyclin-dependent kinase (CDK) inhibitor p21 as a mediator of p53-induced growth arrest is well established. In addition, recent data provide strong evidence for new emerging functions of p21, including a role as a modulator of apoptos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0f5fb67dbc8a6f03e17c881c38e93e
https://doi.org/10.1158/0008-5472.c.6495005.v1
https://doi.org/10.1158/0008-5472.c.6495005.v1
Supplementary Figure Legend from p21 Blocks Irradiation-Induced Apoptosis Downstream of Mitochondria by Inhibition of Cyclin-Dependent Kinase–Mediated Caspase-9 Activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5ebede22b26a7820b62454ead297ab
https://doi.org/10.1158/0008-5472.22366124
https://doi.org/10.1158/0008-5472.22366124