Shuffled lipidation pattern and degree of lipidation determines the membrane interaction behavior of a linear cationic membrane-active peptide

Autor: Dennis Skjøth Bruhn, Sofie Fogh Hedegaard, Marité Cárdenas, Hanne Mørck Nielsen, Himanshu Khandelia

Publikováno v: Hedegaard, S F, Bruhn, D S, Khandelia, H, Cárdenas, M & Nielsen, H M 2020, ' Shuffled lipidation pattern and degree of lipidation determines the membrane interaction behavior of a linear cationic membrane-active peptide ', Journal of Colloid and Interface Science, vol. 578, pp. 584-597 . https://doi.org/10.1016/j.jcis.2020.05.121

Hypothesis Permeation of macromolecular drugs across biological plasma membranes is a major challenge in drug delivery. Cationic cell-penetrating peptides (CPPs) are attractive functional excipient candidates for the delivery of macromolecules across

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233792b9c1e6e669007793376363e623
https://doi.org/10.1016/j.jcis.2020.05.121

Membrane Tubulation in Lipid Vesicles Triggered by the Local Application of Calcium Ions

Autor: Weria Pezeshkian, Gavin D. M. Jeffries, Himanshu Khandelia, Baharan Ali Doosti, Tatsiana Lobovkina, Dennis Skjøth Bruhn, John Hjort Ipsen

Publikováno v: Ali Doosti, B, Pezeshkian, W, Bruhn, D S, Ipsen, J H, Khandelia, H, Jeffries, G D M & Lobovkina, T 2017, ' Membrane tubulation in lipid vesicles triggered by the local application of calcium ions ', Langmuir, vol. 33, no. 41, pp. 11010-11017 . https://doi.org/10.1021/acs.langmuir.7b01461

Experimental and theoretical studies on ion-lipid interactions, predict that binding of calcium ions to cell membranes leads to macroscopic mechanical effects and membrane remodeling. Herein, we provide experimental evidence that a point-source of Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95130c4f13cbc8a8f0edafd450976a56
https://doi.org/10.1021/acs.langmuir.7b01461

About simulations of the Zika virus, and membrane bending by electrostatic potentials (flexo-electricity)

Autor: Himanshu Khandelia, Dennis Skjøth Bruhn, Weria Pezeshkian

Publikováno v: Khandelia, H, Bruhn, D S & Pezeshkian, W 2017, ' About simulations of the Zika virus, and membrane bending by electrostatic potentials (flexo-electricity) ', 5th European Joint Theoretical/experimental Meeting on Membranes, Krakow, Poland, 06/12/2017-08/12/2017 .
University of Southern Denmark

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::722052f98ed44c1383aa2c64f123a5fb
https://portal.findresearcher.sdu.dk/da/publications/bd0d5ac7-3f4b-41a0-9db7-ae1febb45dd9

Formation of Membrane Tubular Protrusions upon Localized Application of Calcium Ions to the Surface of Giant Lipid Vesicles

Autor: Baharan Ali Doosti, Weria Pezeshkian, Himanshu Khandeli, Gavin D. M. Jeffries, Tatsiana Lobovkina, John Hjort Ipsen, Dennis Skjøth Bruhn

Publikováno v: Lobovkina, T, Doosti, B A, Pezeshkian, W, Bruhn, D S, Ipsen, J H, Khandeli, H & Jeffries, G D M 2018, ' Formation of Membrane Tubular Protrusions upon Localized Application of Calcium Ions to the Surface of Giant Lipid Vesicles ', Biophysical Journal, vol. 114, no. 3, Suppl. 1, pp. 562A . https://doi.org/10.1016/j.bpj.2017.11.3074

We present a study on the formation of lipid nanotubular protrusions as a result of localized application of calcium ions to the membrane of giant lipid vesicles. Our findings demonstrate that a point source of calcium ions acting upon a negatively c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5261a508e9065f21a2ca66d0379d89
https://doi.org/10.1016/j.bpj.2017.11.3074

The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca2+-ATPase (SERCA) ATP Hydrolysis from Ca2+ Transport

Autor: Naresh C. Bal, Himanshu Khandelia, Wojciech Kopec, Sanjaya K. Sahoo, Danesh H. Sopariwala, Dennis Skjøth Bruhn, Muthu Periasamy, Sana A. Shaikh

Publikováno v: Sahoo, S K, Shaikh, S A, Sopariwala, D H, Bal, N C, Bruhn, D S, Kopec, W, Khandelia, H & Periasamy, M 2015, ' The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca 2+-ATPase (SERCA) ATP Hydrolysis from Ca 2+ Transport ', Journal of Biological Chemistry, vol. 290, no. 22, pp. 14057-67 . https://doi.org/10.1074/jbc.M115.636738

The sarcoendoplasmic reticulum Ca2+-ATPase (SERCA) is responsible for intracellular Ca2+ homeostasis. SERCA activity in muscle can be regulated by phospholamban (PLB), an affinity modulator, and sarcolipin (SLN), an uncoupler. Although PLB gets dislo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7f411be5d51db38521e005b2fab699
https://pubmed.ncbi.nlm.nih.gov/25882845