Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Dennis S. Hom"'
Autor:
Jay S. Tung, Balazs G. Szoke, David W. G. Wone, Michael A. Pleiss, Albert W. Garofalo, Jon E. Hawkinson, Dennis S. Hom, Heather Zhang, Jennifer L. Marugg, Martin L. Neitzel, Jing Wu, Darren B. Dressen, Jacek Jagodzinski
Publikováno v:
Journal of Medicinal Chemistry. 50:5161-5167
The B1 receptor is an attractive target for the treatment of pain and inflammation. A series of 3-carboxamido-5-phenacylamino pyrazole B1 receptor antagonists are described that exhibit good potency against B1 and high selectivity over B2. Initially,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4a3be695c64bc74dc9e0ae3d18382e
https://doi.org/10.1021/jm051292n
https://doi.org/10.1021/jm051292n
Autor:
Angie Wadsworth, Lany Ruslim, Bhushan Samant, Dennis S. Hom, Linda Chen, Hongbing Zhang, Juri Y Fukuda, Mei-Chuan Ko, Anna Liao, Stellanie Simmonds, Karla P. Zeitz, Wes Zmolek, Raymond A. Chavez, Michael P. Bova, Balazs G. Szoke, Mark Dreyer, Albert W. Garofalo, Annika B. Malmberg, Eduardo R. Butelman, Ryan Holcomb, Jon E. Hawkinson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:619-630
The bradykinin B(1) receptor plays a critical role in chronic pain and inflammation, although efforts to demonstrate efficacy of receptor antagonists have been hampered by species-dependent potency differences, metabolic instability, and low oral exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd5c128d96318ca657dbc995c3d83a7
https://doi.org/10.1124/jpet.107.120352
https://doi.org/10.1124/jpet.107.120352