Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Dennis S Metselaar"'
Autor:
Dennis S. Metselaar, Michaël H. Meel, Joshua R. Goulding, Aimeé du Chatinier, Leyla Rigamonti, Piotr Waranecki, Neal Geisemeyer, Mark C. de Gooijer, Marjolein Breur, Jan Koster, Sophie E.M. Veldhuijzen van Zanten, Marianna Bugiani, Niels E. Franke, Alyssa Reddy, Pieter Wesseling, Gertjan J.L. Kaspers, Esther Hulleman
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101700- (2024)
Summary: Atypical teratoid/rhabdoid tumors (ATRTs) are highly malignant embryonal tumors of the central nervous system with a dismal prognosis. Using a newly developed and validated patient-derived ATRT culture and xenograft model, alongside a panel
Externí odkaz:
https://doaj.org/article/dad8aa161f6e4aad834b1c8a6839ea6b
Publikováno v:
Clinical and Translational Discovery, Vol 2, Iss 4, Pp n/a-n/a (2022)
Abstract In recent years, the discovery and development of clustered regularly interspaced short palindromic repeats (CRISPR) technology has revolutionized and accelerated functional genetic screening in cancer research. In this review, we discuss di
Externí odkaz:
https://doaj.org/article/c367fff43695451181851efc3302fa01
Autor:
Dennis S. Metselaar, Aimée du Chatinier, Michaël H. Meel, Giovanna ter Huizen, Piotr Waranecki, Joshua R. Goulding, Marianna Bugiani, Jan Koster, Gertjan J.L. Kaspers, Esther Hulleman
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104398- (2022)
Summary: Diffuse midline gliomas (DMG) are highly malignant incurable pediatric brain tumors. In this study, we show that Aurora kinase A (AURKA) is overexpressed in DMG and can be used as a therapeutic target. Additionally, AURKA inhibition combined
Externí odkaz:
https://doaj.org/article/db96f8f4ad9a452e998e3fd3254e1990
Autor:
Dennis S. Metselaar, Michaël H. Meel, Bente Benedict, Piotr Waranecki, Jan Koster, Gertjan J.L. Kaspers, Esther Hulleman
Publikováno v:
EBioMedicine, Vol 50, Iss , Pp 81-92 (2019)
Background: Pediatric high-grade gliomas (pHGG) are the leading cause of cancer-related death during childhood. Due to their diffuse growth characteristics, chemoresistance and location behind the blood-brain barrier (BBB), the prognosis of pHGG has
Externí odkaz:
https://doaj.org/article/ab0572c7175b4e10b24ebea070bfba27
Autor:
Dennis S. Metselaar, Aimée du Chatinier, Iris Stuiver, Gertjan J. L. Kaspers, Esther Hulleman
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Pediatric high-grade gliomas (pHGG) are the leading cause of cancer-related death in children. These epigenetically dysregulated tumors often harbor mutations in genes encoding histone 3, which contributes to a stem cell-like, therapy-resistant pheno
Externí odkaz:
https://doaj.org/article/dd98f2500cad417b9d8b8be2aff9e3d4
Autor:
Ilango Balakrishnan, Etienne Danis, Angela Pierce, Krishna Madhavan, Dong Wang, Nathan Dahl, Bridget Sanford, Diane K. Birks, Nate Davidson, Dennis S. Metselaar, Michaël Hananja Meel, Rakeb Lemma, Andrew Donson, Trinka Vijmasi, Hiroaki Katagi, Ismail Sola, Susan Fosmire, Irina Alimova, Jenna Steiner, Ahmed Gilani, Esther Hulleman, Natalie J. Serkova, Rintaro Hashizume, Cynthia Hawkins, Angel M. Carcaboso, Nalin Gupta, Michelle Monje, Nada Jabado, Kenneth Jones, Nicholas Foreman, Adam Green, Rajeev Vibhakar, Sujatha Venkataraman
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108286- (2020)
Summary: Diffuse intrinsic pontine glioma (DIPG) is an incurable brain tumor of childhood characterized by histone mutations at lysine 27, which results in epigenomic dysregulation. There has been a failure to develop effective treatment for this tum
Externí odkaz:
https://doaj.org/article/df550ba18a7344fb83017de0c06084bc
Publikováno v:
MethodsX, Vol 5, Iss , Pp 173-183 (2018)
Pediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are rare, but rapidly fatal malignancies of the central nervous system (CNS), and the leading cause of cancer-related death in children. Besides the scarcity of available
Externí odkaz:
https://doaj.org/article/38f98d640b1245148868c9185af098ef
Autor:
Esther Hulleman, Gertjan J.L. Kaspers, Dannis G. van Vuurden, Olaf van Tellingen, Timothy N. Phoenix, Marianna Bugiani, Ángel Montero Carcaboso, Eric H. Raabe, Rintaro Hashizume, Jan Koster, Jos W.R. Twisk, Laurine E. Wedekind, Tonny Lagerweij, Levi C.M. Buil, Marjolein Breur, Piotr Waranecki, Kenn Zwaan, A. Charlotte P. Sewing, Dennis S. Metselaar, Mark C. de Gooijer, Michaël H. Meel
Purpose:Diffuse intrinsic pontine glioma (DIPG) is an incurable type of pediatric brain cancer, which in the majority of cases is driven by mutations in genes encoding histone 3 (H3K27M). We here determined the preclinical therapeutic potential of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426e325eb37e62297bb71b9385084f22
https://doi.org/10.1158/1078-0432.c.6529571
https://doi.org/10.1158/1078-0432.c.6529571
Autor:
Esther Hulleman, Gertjan J.L. Kaspers, Dannis G. van Vuurden, Olaf van Tellingen, Timothy N. Phoenix, Marianna Bugiani, Ángel Montero Carcaboso, Eric H. Raabe, Rintaro Hashizume, Jan Koster, Jos W.R. Twisk, Laurine E. Wedekind, Tonny Lagerweij, Levi C.M. Buil, Marjolein Breur, Piotr Waranecki, Kenn Zwaan, A. Charlotte P. Sewing, Dennis S. Metselaar, Mark C. de Gooijer, Michaël H. Meel
Legends pertaining to supplementary figures and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f3f0b188d7068471497ed95dac109a
https://doi.org/10.1158/1078-0432.22477094
https://doi.org/10.1158/1078-0432.22477094
Autor:
Esther Hulleman, Gertjan J.L. Kaspers, Dannis G. van Vuurden, Olaf van Tellingen, Timothy N. Phoenix, Marianna Bugiani, Ángel Montero Carcaboso, Eric H. Raabe, Rintaro Hashizume, Jan Koster, Jos W.R. Twisk, Laurine E. Wedekind, Tonny Lagerweij, Levi C.M. Buil, Marjolein Breur, Piotr Waranecki, Kenn Zwaan, A. Charlotte P. Sewing, Dennis S. Metselaar, Mark C. de Gooijer, Michaël H. Meel
File containing all supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081cd3246c4a6479a7a296a32247511d
https://doi.org/10.1158/1078-0432.22477091
https://doi.org/10.1158/1078-0432.22477091