Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Dennis S, France"'
Breast cancer exhibits a propensity to metastasize to bone, resulting in debilitating skeletal complications associated with significant morbidity and poor prognosis. The cross-talk between metastatic cancer cells and bone is critical to the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db186f2051dfe63fe72b0aef4f0c37ab
https://doi.org/10.1158/1535-7163.c.6535770
https://doi.org/10.1158/1535-7163.c.6535770
Autor:
Chiang J. Li, David S. Leggett, Magdi M. Moussa, Jason Hill, Mark A. Ashwell, Dennis S. France, Chang-Rung Chen, Youzhi Li, Sébastien Jeay, Neru Munshi
Supplementary Data from ARQ 197, a Novel and Selective Inhibitor of the Human c-Met Receptor Tyrosine Kinase with Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4ce340728dfa8b147d5d39ba35a58f
https://doi.org/10.1158/1535-7163.22485296
https://doi.org/10.1158/1535-7163.22485296
Autor:
Chiang J. Li, David S. Leggett, Magdi M. Moussa, Jason Hill, Mark A. Ashwell, Dennis S. France, Chang-Rung Chen, Youzhi Li, Sébastien Jeay, Neru Munshi
The met proto-oncogene is functionally linked with tumorigenesis and metastatic progression. Validation of the receptor tyrosine kinase c-Met as a selective anticancer target has awaited the emergence of selective c-Met inhibitors. Herein, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266530d573120c053bc6898e1d8c2b56
https://doi.org/10.1158/1535-7163.c.6531881.v1
https://doi.org/10.1158/1535-7163.c.6531881.v1
Autor:
Mark A. Ashwell, Jean-Marc Lapierre, Christopher Brassard, Karen Bresciano, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Terence Hall, Jason Hill, Eoin Kelleher, Sampada Khanapurkar, Darin Kizer, Steffi Koerner, Jeff Link, Yanbin Liu, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Khanh Nguyen, Robert Nicewonger, Rocio Palma, Jeff Szwaya, Manish Tandon, Uma Uppalapati, David Vensel, Laurie P. Volak, Erika Volckova, Neil Westlund, Hui Wu, Rui-Yang Yang, Thomas C. K. Chan
Publikováno v:
Journal of Medicinal Chemistry. 55:5291-5310
This paper describes the implementation of a biochemical and biophysical screening strategy to identify and optimize small molecule Akt1 inhibitors that act through a mechanism distinct from that observed for kinase domain ATP-competitive inhibitors.