Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Dennis Ricardo August Mans"'
1
Anti-Cancer Drug Discovery and Development in Brazil: Targeted Plant Collection as a Rational Strategy to Acquire Candidate Anti-Cancer Compounds
Autor: Gilberto Schwartsmann, Dennis Ricardo August Mans, Adriana Brondani da Rocha
Publikováno v: Scopus-Elsevier
Throughout medical history, plant products have been shown to be valuable sources of novel anti-cancer drugs. Examples are the Vinca alkaloids, the taxanes, and the camptothecins, derived from the Madagscan periwinkle plant Catharantus roseus, the Pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227f351559537d8b23280146e8c3af8f
https://doi.org/10.1634/theoncologist.5-3-185
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2
Tamoxifen inhibits particulate-associated protein kinase C activity, and sensitises cultured human glioblastoma cells not to etoposide but to γ-radiation and BCNU
Autor: A.F Logullo, Elena Aida Bernard, A Brondani da Rocha, Dennis Ricardo August Mans, Cristiano Ruschel, Gilberto Schwartsmann, Albert Leyva, L.A Wetmore
Publikováno v: European Journal of Cancer. 35:833-839
We investigated the potential mechanisms of tamoxifen cytotoxicity in the U-373, U-138, and U-87 human glioblastoma cell lines, namely interference with protein kinase C (PKC) activity, the oestrogen receptor, and/or the production of transforming gr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2648cf22c44058e59fda5388d2a9381f
https://doi.org/10.1016/s0959-8049(99)00003-9
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3
Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?
Autor: Andrea Regner, Gilberto Schwartsmann, A. B. da Rocha, Dennis Ricardo August Mans
Publikováno v: ResearcherID
Learning Objectives After completing this course, the reader should be able to: Understand protein kinase C (PKC) in signal transduction pathways. Understand protein kinase C (PKC) in tumor cell proliferation and invasion Understand protein kinase C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ced0fe47d1dc9e8b333f66a052f779
https://pubmed.ncbi.nlm.nih.gov/11854544
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4
Irinotecan and oxaliplatin: an overview of the novel chemotherapeutic options for the treatment of advanced colorectal cancer
Autor: Ivana Grivicich, Gilberto Schwartsmann, Godefridus J. Peters, Dennis Ricardo August Mans
Publikováno v: Brazilian Journal of Medical and Biological Research, Volume: 34, Issue: 9, Pages: 1087-1103, Published: SEP 2001
Brazilian Journal of Medical and Biological Research, Vol 34, Iss 9, Pp 1087-1103 (2001)
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Brazilian Journal of Medical and Biological Research v.34 n.9 2001
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Scopus-Elsevier
Colorectal cancer is one of the most frequent malignancies in humans and an important cause of cancer death. Metastatic colorectal cancer remains incurable with available systemic therapeutic options. The most active cytotoxic drug against this malig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e09a1ce29289b797010ecce54c7c318
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000900001&lng=en&tlng=en
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5
Cellular and clinical pharmacokinetic/pharmacodynamic basis for lack of efficacy of 21-day continuous topotecan in patients with untreated advanced adenocarcinoma of the pancreas
Autor: Dennis Ricardo August Mans, Maino M, Cancela Ai, Leonardo Almeida, Di Leone L, Ferrary Caldas Ap, Ivana Grivicich, Gilberto Schwartsmann, Brondani da Rocha A
Publikováno v: Scopus-Elsevier
Background In a phase II study, topotecan was evaluated for response and toxicity in patients with advanced pancreatic carcinoma at the schedule of 0.7 mg/m2/day q 21 days q 28 days. Methods Responses were assessed after at least 2 courses using WHO
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386fab660908c289a4bf2de04b34459a
https://pubmed.ncbi.nlm.nih.gov/11218186
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6
Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular-signal-regulated kinase and ornithine decarboxylase
Autor: A. B. da Rocha, C. de Lima, Vitor Monteiro, Jose Claudio Fonseca Moreira, Richard Rodnight, Andreia Kist Fernandes, Guido Lenz, Danielle Goncalves, Dennis Ricardo August Mans, Algemir Lunardi Brunetto, Gilberto Schwartsmann
Publikováno v: Pathobiology : journal of immunopathology, molecular and cellular biology. 68(3)
We investigated the involvement of protein kinase C (PKC) in the in vitro invasiveness of the A-172, U-87 and U-373 human glioma cell lines, as well as the role of ornithine decarboxylase (ODC) and/or extracellular-signal-regulated kinase (ERK) in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb9de7539fba84a9da7ad460d461de1
https://pubmed.ncbi.nlm.nih.gov/11174068
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7
Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in humancolon carcinoma cell lines
Autor: Godefridus J. Peters, Gilberto Schwartsmann, Ivana Grivicich, Dennis Ricardo August Mans
Publikováno v: European Journal of Cancer, 35, 1851-1861. Pergamon
Mans, D R A, Grivicich, I, Peters, G J & Schwartsmann, G 1999, ' Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in humancolon carcinoma cell lines ', European Journal of Cancer, vol. 35, pp. 1851-1861 . https://doi.org/10.1016/S0959-8049(99)00222-1
We evaluated irinotecan (CPT-11) together with 5-fluorouracil (5-FU) for improved cell growth inhibition with respect to that by either agent alone in the human colon carcinoma cell lines SW620, HT-29 and SNU-C4. Cells were exposed for 24 h to each d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c877f722e36ec903b419fc2c1cc1e150
https://research.vumc.nl/en/publications/d94a4699-6828-4974-a6f1-296c680cf234
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8
Phase II study of pentosan polysulfate (PPS) in patients with AIDS-related Kaposi's sarcoma
Autor: Ernesto Sander, Eduardo Sprinz, Dennis Ricardo August Mans, Richard Koya, Ivana Grivicich, Luciane Kalakun, Nise Yamagushi, Gilberto Schwartsmann
Publikováno v: Scopus-Elsevier
Aims and background To evaluate the response rate, toxicity and survival of patients with AIDS-related Kaposi's sarcoma (AIDS-KS) treated in a phase II clinical trial of pentosan polysulpate (PPS), an inhibitor of basic-fibroblast growth factor (b-FG
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b422a2478c1f9a15193ef1d05459ccdf
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029803230&partnerID=MN8TOARS
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