Výsledky vyhledávání - "Dennis R. Patton"

Conformational restriction of angiotensin II: cyclic analogs having high potency

Autor: Monica S. Brown, Gillian M. Olins, Maria A. Palomo, Ellen G. Mcmahon, Emily J. Reinhard, Kerry L. Spear, Dennis R. Patton

Publikováno v: Journal of Medicinal Chemistry. 33:1935-1940

Cyclic analogues of angiotensin II (AII) were synthesized by connecting the side chains of residues 3 and 5 via a disulfide bridge. Appropriate conformational constraints afforded an analogue, [Hcy 3,5 ]AII, having high contractile activity (pD 2 = 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c08519112f894866cdba4e79b775ca
https://doi.org/10.1021/jm00169a019

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Structure-activity relationships for the carboxy-terminus-truncated analogs of angiotensin II, a new class of angiotensin II antagonists

Autor: Maria A. Palomo, Gillian M. Olins, G J Smits, K S Salles, Joan M. O'Neal, P R Bovy, Dennis R. Patton, A. J. Trapani, J P Koepke, Ellen G. Mcmahon

Publikováno v: Journal of Medicinal Chemistry. 33:1477-1482

A series of analogues of the recently reported angiotensin II (AII) antagonist [Sar1]AII-(1-7)-amide or des-Phe8[Sar1]AII (3) have been prepared by solid-phase synthesis and purified by reverse-phase liquid chromatography. The agonist and antagonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1df0bc239548aec2e50ed2041de3888
https://doi.org/10.1021/jm00167a030

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Specific receptors for atriopeptin III in rabbit lung

Autor: Delores J. Blehm, Gillian M. Olins, Dennis R. Patton, Foe S. Tjoeng

Publikováno v: Biochemical and Biophysical Research Communications. 140:302-307

Binding studies revealed the presence of a single class of high affinity binding sites for atriopeptin III on rabbit lung membranes. An apparent dissociation constant (Kd) of 0.32 nM and a binding capacity of 166 fmol/mg protein was determined. Bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36e9936f5bf0ceae3fcfee53aa132a6
https://doi.org/10.1016/0006-291x(86)91090-9

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Analogs of atriopeptin(103-125)amide having high binding selectivity

Autor: Gillian M. Olins, Monica S. Brown, Dennis R. Patton, Kerry L. Spear

Publikováno v: Journal of Medicinal Chemistry. 32:1094-1098

Analogues of atriopeptin(103-125)amide were prepared having a disulfide bridge at positions different from that found in the natural product. Most of these conformationally perturbed peptides were found to bind selectively to one subclass of binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841fe0c5281119e10f38dae9d45df6db
https://doi.org/10.1021/jm00125a026

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A linear analog of atrial natriuretic peptide (ANP) discriminates guanylate cyclase-coupled ANP receptors from non-coupled receptors

Autor: P P Mehta, Dennis R. Patton, Philippe R. Bovy, Gillian M. Olins

Publikováno v: Journal of Biological Chemistry. 263:10989-10993

Atrial natriuretic peptide (ANP) contains a disulfide which is generally considered to be required for biological activity. A truncated linear ANP analog, des-Cys105,Cys121-ANP-(104-126) (referred to as analog I), that lacks the 2 cysteine residues o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01d4dad52a249c3394112a8c1bc80349
https://doi.org/10.1016/s0021-9258(18)38067-0

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A Synthetic Linear Decapeptide Binds to the Atrial Natriuretic Peptide Receptors and Demonstrates Cyclase Activation and Vasorelaxant Activity

Autor: Joseph R. Schuh, Philippe R. Bovy, Delores J. Blehm, Ellen G. Mcmahon, Gillian M. Olins, P P Mehta, Dennis R. Patton, Joan M. O'Neal, Maria A. Palomo

Publikováno v: Journal of Biological Chemistry. 264:20309-20313

A linear decapeptide, [cyclohexylalanine 106]ANP-(105-114)NH2 (1), where ANP is atrial natriuretic peptide, was prepared by solid phase synthesis and purified by reverse-phase liquid chromatography. This novel peptide was found to bind to ANP recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6ec6780e6d4608f831709c2cfd19228
https://doi.org/10.1016/s0021-9258(19)47063-4

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Conformationally restricted analogues of atriopeptin(103-125)amide

Autor: Gillian M. Olins, Maria A. Palomo, Ellen G. Mcmahon, Kerry L. Spear, Emily J. Reinhard, Dennis R. Patton

Publikováno v: Journal of medicinal chemistry. 32(1)

Conformationally restricted analogues of atriopeptin(103-125)amide were prepared by synthesizing novel bicyclic peptides in which a second disulfide bridge linking residues 108 and 117 was introduced. These syntheses were shown to proceed with no sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb0e889f660a19b17c3b48b82e00baf
https://pubmed.ncbi.nlm.nih.gov/2535877

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Identification of structural requirements for analogues of atrial natriuretic peptide (ANP) to discriminate between ANP receptor subtypes

Autor: Gillian M. Olins, Joan M. O'Neal, Dennis R. Patton, Philippe R. Bovy

Publikováno v: Journal of medicinal chemistry. 32(4)

The structure-activity relationships for affinity and selective binding of atrial natriuretic peptide (ANP) and analogues to guanylate cyclase coupled (CC) and non-cyclase coupled (NC) receptors in rabbit lung membranes are described. We have designe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c1210bb3a1b5b4d77b680214f3e3df
https://pubmed.ncbi.nlm.nih.gov/2564895

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