Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dennis R. Compton"'
Autor:
John A. Katzenellenbogen, Matthew S. Burge, C. Richard Lyttle, Kyla Gallacher, Jennifer L. Green, Gary Hattersley, Maysoun Shomali, Alexei Tchesnokov, Dottie Paquin, Louis St. L. O’Dea, Dennis R. Compton, Hillary Herendeen, Bishwabhusan Sahoo, Chris P. Miller, Sean Kerrigan, Michael Nickels
Publikováno v:
ACS Medicinal Chemistry Letters. 2:124-129
This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49883bca23cc766e3a9dc26159dd75b
https://doi.org/10.1021/ml1002508
https://doi.org/10.1021/ml1002508
Autor:
Benita S. Katzenellenbogen, Sanjay Sharma, Kendall W. Nettles, John A. Katzenellenbogen, Kathryn E. Carlson, Younchang Kim, Hai-Bing Zhou, Shubin Sheng, Dennis R. Compton, Andrzej Joachimiak, Geoffrey L. Greene
Publikováno v:
Journal of medicinal chemistry. 50(2)
2,3-Diarylpyrazolo[1,5-a]pyrimidines are estrogen receptor (ER) antagonists of modest potency that we have described previously. Guided by the crystal structure of an ER-ligand complex that we have obtained with one of these compounds, we prepared an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df7b42694258d87abdff112c8135bac
https://pubmed.ncbi.nlm.nih.gov/17228884
https://pubmed.ncbi.nlm.nih.gov/17228884
Autor:
Benita S. Katzenellenbogen, Kathryn E. Carlson, Natalie A. Rebacz, Shubin Sheng, Dennis R. Compton, John A. Katzenellenbogen, In Young Lee
Publikováno v:
Journal of medicinal chemistry. 47(24)
In our search for novel subtype-selective estrogen receptor (ER) ligands, we have examined various heterocyclic units as core structural elements. Here, we have investigated the fused, bicyclic pyrazolo[1,5-a]pyrimidine core, which is a system that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009978e334e1619f9334ca84472e9eff
https://pubmed.ncbi.nlm.nih.gov/15537344
https://pubmed.ncbi.nlm.nih.gov/15537344
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(22)
We have examined the pyrazolo[1,5-a]pyrimidine scaffold as a novel core structure for estrogen receptor ligands. Attachment of various substituents has helped to define the orientation of this heterocycle in the ligand-binding pocket as one in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425b85a0f43d6d30c65e7ead8379982e
https://pubmed.ncbi.nlm.nih.gov/15482947
https://pubmed.ncbi.nlm.nih.gov/15482947
Autor:
Hai-Bing Zhou, Shubin Sheng, Dennis R. Compton, Younchang Kim, Andrzej Joachimiak, Sanjay Sharma, Kathryn E. Carlson, Benita S. Katzenellenbogen, Kendall W. Nettles, Geoffrey L. Greene, John A. Katzenellenbogen
Publikováno v:
Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 2, p399-403, 5p