Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Dennis R. Clayton"'
Autor:
Marianela G. Dalghi, Ella DuRie, Wily G. Ruiz, Dennis R. Clayton, Nicolas Montalbetti, Stephanie B. Mutchler, Lisa M. Satlin, Thomas R. Kleyman, Marcelo D. Carattino, Yun Stone Shi, Gerard Apodaca
Publikováno v:
Physiological Reports, Vol 12, Iss 9, Pp n/a-n/a (2024)
Abstract The epithelial cells that line the kidneys and lower urinary tract are exposed to mechanical forces including shear stress and wall tension; however, the mechanosensors that detect and respond to these stimuli remain obscure. Candidates incl
Externí odkaz:
https://doaj.org/article/5aa6f4ad49de43d68e2bfdfa1f282fab
Autor:
Aidan W. Porter, Diep N. Nguyen, Dennis R. Clayton, Wily G. Ruiz, Stephanie M. Mutchler, Evan C. Ray, Allison L. Marciszyn, Lubika J. Nkashama, Arohan R. Subramanya, Sebastien Gingras, Thomas R. Kleyman, Gerard Apodaca, Linda M. Hendershot, Jeffrey L. Brodsky, Teresa M. Buck
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Molecular chaperones are responsible for maintaining cellular homeostasis, and one such chaperone, GRP170, is an endoplasmic reticulum (ER) resident that oversees both protein biogenesis and quality control. We previously discovered that GRP170 regul
Externí odkaz:
https://doaj.org/article/2095d64dac0b445d9ccc8fd828f7f516
Autor:
Marianela G. Dalghi, Wily G. Ruiz, Dennis R. Clayton, Nicolas Montalbetti, Stephanie L. Daugherty, Jonathan M. Beckel, Marcelo D. Carattino, Gerard Apodaca
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
The mechanisms that link visceral mechanosensation to the perception of internal organ status (i.e., interoception) remain elusive. In response to bladder filling, the urothelium releases ATP, which is hypothesized to stimulate voiding function by co
Externí odkaz:
https://doaj.org/article/8abfefc5202543cabde55b70bd38d134
Autor:
Dennis R, Clayton, Wily G, Ruiz, Marianela G, Dalghi, Nicolas, Montalbetti, Marcelo D, Carattino, Gerard, Apodaca
Publikováno v:
American journal of physiology. Renal physiology. 323(3)
Fibroblasts are crucial to normal and abnormal organ and tissue biology, yet we lack basic insights into the fibroblasts that populate the bladder wall. Candidates may include bladder interstitial cells (also referred to as myofibroblasts, telocytes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ced6db9f44668970405eb918014f3249
https://pubmed.ncbi.nlm.nih.gov/35834272
https://pubmed.ncbi.nlm.nih.gov/35834272
Autor:
Dennis R. Clayton, Wily G. Ruiz, Marianela G. Dalghi, Nicolas Montalbetti, Marcelo D. Carattino, Gerard Apodaca
Publikováno v:
American Journal of Physiology-Renal Physiology. 323:F299-F321
We currently lack basic insights into the fibroblasts that populate the bladder wall. By exploring the ultrastructure of mouse bladder connective tissue cells, combined with analyses of their gene and protein expression, our study revealed that PDGRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d35a94c9e9cc0e9a8eb960a0e244abb9
https://doi.org/10.1152/ajprenal.00135.2022
https://doi.org/10.1152/ajprenal.00135.2022
Bladder infection with uropathogenic Escherichia coli increases the excitability of afferent neurons
Autor:
Marcelo D. Carattino, Nicolas Montalbetti, Dennis R. Clayton, Sheldon I. Bastacky, Wily G. Ruiz, Marianela G. Dalghi, Gerard Apodaca
Publikováno v:
American Journal of Physiology-Renal Physiology. 322:F1-F13
Urinary tract infections (UTIs) cause bladder hyperactivity and pelvic pain, but the underlying causes of these symptoms remain unknown. We investigated whether afferent sensitization contributes to the bladder overactivity and pain observed in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03d0938ba9ae83641326b328d91bbad6
https://doi.org/10.1152/ajprenal.00167.2021
https://doi.org/10.1152/ajprenal.00167.2021
Autor:
Nicolas, Montalbetti, Marianela G, Dalghi, Sheldon I, Bastacky, Dennis R, Clayton, Wily G, Ruiz, Gerard, Apodaca, Marcelo D, Carattino
Publikováno v:
Am J Physiol Renal Physiol
Urinary tract infections (UTIs) cause bladder hyperactivity and pelvic pain, but the underlying causes of these symptoms remain unknown. We investigated whether afferent sensitization contributes to the bladder overactivity and pain observed in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55928824a240e02e0ff6e6d11386bec9
https://pubmed.ncbi.nlm.nih.gov/34779263
https://pubmed.ncbi.nlm.nih.gov/34779263
Autor:
Steven T Truschel, Dennis R Clayton, Jonathan M Beckel, Jonathan G Yabes, Yi Yao, Amanda Wolf-Johnston, Lori A Birder, Gerard Apodaca
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198817 (2018)
Lysosomal dysfunction is associated with a number of age-related pathologies that affect all organ systems. While much research has focused on neurodegenerative diseases and aging-induced changes in neurons, much less is known about the impact that a
Externí odkaz:
https://doaj.org/article/b24393ea745b48c1b626f706b41e29d9
Autor:
Gerard Apodaca, Marcelo D. Carattino, Nicolas Montalbetti, Marianela G. Dalghi, Dennis R. Clayton, Wily G. Ruiz
Publikováno v:
Journal of Visualized Experiments.
In addition to forming a high-resistance barrier, the urothelium lining the renal pelvis, ureters, bladder, and proximal urethra is hypothesized to sense and transmit information about its environment to the underlying tissues, promoting voiding func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683dbe2538d12fe6a978e9a9f4f7c258
https://doi.org/10.3791/64584-v
https://doi.org/10.3791/64584-v
Autor:
Teresa M. Buck, Aidan Porter, Wily G. Ruiz, Dennis R. Clayton, Stephanie M. Mutchler, Evan C. Ray, Allison L. Marciszyn, Lubika J. NKashama, Arohan R. Subramanya, Sebastien Gingras, Thomas Kleyman, Gerard Apodaca, Linda M. Hendershot, Jeffrey L. Brodsky
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec69637d72f0f87a46f2846a23934a7a
https://doi.org/10.1096/fasebj.2022.36.s1.r4334
https://doi.org/10.1096/fasebj.2022.36.s1.r4334