Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dennis R. Chidester"'
Autor:
Lawrence W. Fitzgerald, Anthony J. Cocuzza, Steven Culp, Dennis R. Chidester, Paul J. Gilligan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1063-1066
The Suzuki reaction has been used to synthesize a variety of aryl-substituted heterocyclic antagonists of the CRH1 receptor. Examples with several different heterocyclic cores are potent CRH receptor ligands.
Autor:
Charles R. Arnold, Frank W. Hobbs, Steven Culp, Dennis R. Chidester, Paul J. Gilligan, Jerry A. Yarem, Anthony J. Cocuzza, Lawrence W. Fitzgerald
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1057-1062
A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.
Autor:
Steven Culp, Dennis R. Chidester, Paul J. Gilligan, Lawrence W. Fitzgerald, Anthony J. Cocuzza
Publikováno v:
ChemInform. 30
The Suzuki reaction has been used to synthesize a variety of aryl-substituted heterocyclic antagonists of the CRH1 receptor. Examples with several different heterocyclic cores are potent CRH receptor ligands.
Autor:
Charles R. Arnold, Steven Culp, Paul J. Gilligan, Dennis R. Chidester, Anthony J. Cocuzza, Lawrence W. Fitzgerald, Frank W. Hobbs, Jerry A. Yarem
Publikováno v:
ChemInform. 30
A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.
Autor:
Lee T. Bacheler, George L. Trainor, Susan Jeffrey, Rodney L. Parsons, Susan Erickson-Viitanen, Dennis R. Chidester, Soo S. Ko, Anthony J. Cocuzza, Beverly C. Cordova
Publikováno v:
ChemInform. 32
Two series of efavirenz analogues have been developed: one in which the cyclopropane ring has been replaced by small heterocycles and another in which the entire acetylenic side chain has been replaced by alkyloxy groups. Several members of both seri
Autor:
Soo S. Ko, Susan Jeffrey, Sharon Diamond, Carolyn A. Weigelt, Susan Erickson-Viitanen, James D. Rodgers, Beverly C. Cordova, Dennis R. Chidester, Anthony J. Cocuzza, Ronald M. Klabe, Lee T. Bacheler
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(11)
A series of 4,1-benzoxazepinone analogues of efavirenz (Sustiva) as potent NNRTIs has been discovered. The cis-3-alkylbenzoxazepinones are more potent then the trans isomers and can be synthesized preferentially by a novel stereoselective cyclization
Autor:
Lee T. Bacheler, George L. Trainor, Susan Jeffrey, Beverly C. Cordova, Soo S. Ko, Rodney L. Parsons, Dennis R. Chidester, Susan Erickson-Viitanen, Anthony J. Cocuzza
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(9)
Two series of efavirenz analogues have been developed: one in which the cyclopropane ring has been replaced by small heterocycles and another in which the entire acetylenic side chain has been replaced by alkyloxy groups. Several members of both seri