Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dennis R. Benjamin"'
Autor:
Dennis R. Benjamin, Jason Neale, Lori Westendorf, Joshua H. Hunter, Julia H. Cochran, Vincent Feng-Sheng Shih, Michelle L. Ulrich, Fu Li
To provide a better understanding of the pharmacokinetics–pharmacodynamics relationships of antibody-based drugs, we analyzed several chimeric and humanized monoclonal antibodies or antibody–drug conjugates (ADC) for PK and efficacy among four st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8374d132b770669b196b144950686f40
https://doi.org/10.1158/1535-7163.c.6538009.v1
https://doi.org/10.1158/1535-7163.c.6538009.v1
Autor:
Dennis R. Benjamin, Jason Neale, Lori Westendorf, Joshua H. Hunter, Julia H. Cochran, Vincent Feng-Sheng Shih, Michelle L. Ulrich, Fu Li
Additional PK measurements and antibody sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a5cfc99a95240fc821025d94bd15b7
https://doi.org/10.1158/1535-7163.22505254
https://doi.org/10.1158/1535-7163.22505254
Autor:
Dennis R. Benjamin, Nancy Whiting, Heather A. Van Epps, Lori Westendorf, Albina Nesterova, Jamie B. Miyamoto, Heather Kostner, Joshua H. Hunter, Steve Duniho, Martha E. Anderson, Leia M. Smith, Django Sussman
In this article, we describe a novel antibody–drug conjugate (ADC; SGN–LIV1A), targeting the zinc transporter LIV-1 (SLC39A6) for the treatment of metastatic breast cancer. LIV-1 was previously known to be expressed by estrogen receptor–positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3042d158186c555911d8bdd687fbbe
https://doi.org/10.1158/1535-7163.c.6537138
https://doi.org/10.1158/1535-7163.c.6537138
Autor:
Dennis R. Benjamin, Nancy Whiting, Heather A. Van Epps, Lori Westendorf, Albina Nesterova, Jamie B. Miyamoto, Heather Kostner, Joshua H. Hunter, Steve Duniho, Martha E. Anderson, Leia M. Smith, Django Sussman
Supplementary Table 1: Surface antigen density impacts in vitro potency of anti-LIV-1 ADC . MCF-7 ATCC cells from three sources with varying levels of LIV-1 expression were tested with SGN-LIV1A for cytotoxicity. Lower antigen density resulted in dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a51b89562749a45548755643dceabbd
https://doi.org/10.1158/1535-7163.22502631.v1
https://doi.org/10.1158/1535-7163.22502631.v1
Autor:
Che-Leung Law, Dennis R. Benjamin, Lori Westendorf, Xinqun Zhang, Germein Linares, Ivan J. Stone, Mechthild Jonas, Michelle Ulrich, Fu Li
The primary mechanism of antibody–drug conjugates (ADC) is targeted delivery of a cytotoxic payload to tumor cells via cancer-associated membrane receptors. However, the tumor microenvironment likely plays a role in ADC penetration, distribution, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60535f598f017fba5fe5815d0e67e54e
https://doi.org/10.1158/1535-7163.c.6539563
https://doi.org/10.1158/1535-7163.c.6539563
Autor:
Che-Leung Law, Dennis R. Benjamin, Lori Westendorf, Xinqun Zhang, Germein Linares, Ivan J. Stone, Mechthild Jonas, Michelle Ulrich, Fu Li
Legends of supplementary Figure S1, S2 and S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed69dd0cf4638d7221e966054f3c81b
https://doi.org/10.1158/1535-7163.22510279
https://doi.org/10.1158/1535-7163.22510279
Autor:
Dennis R. Benjamin, Eric J. Feldman, Che-Leung Law, Peter D. Senter, Sa A. Wang, Maitrayee Goswami, Timothy S. Lewis, Mechthild Jonas, Weiping Zeng, Ivan J. Stone, Martha E. Anderson, Michelle Ulrich, Kerry Klussman, Django Sussman, Ashley Cronkite, Lucy Pan, John Valliere-Douglass, Lori Westendorf, Roland B. Walter, Changpu Yu, May Kung Sutherland, Fu Li
Gating strategy, primary AML cytotoxicity assay,additional cell liens for pH2AX assay and caspase assay, and h7G3ec antibody sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6621500ceec28e5ffa45ca4f5d714e
https://doi.org/10.1158/1535-7163.22505200
https://doi.org/10.1158/1535-7163.22505200
Autor:
Dennis R. Benjamin, Eric J. Feldman, Che-Leung Law, Peter D. Senter, Sa A. Wang, Maitrayee Goswami, Timothy S. Lewis, Mechthild Jonas, Weiping Zeng, Ivan J. Stone, Martha E. Anderson, Michelle Ulrich, Kerry Klussman, Django Sussman, Ashley Cronkite, Lucy Pan, John Valliere-Douglass, Lori Westendorf, Roland B. Walter, Changpu Yu, May Kung Sutherland, Fu Li
Treatment choices for acute myelogenous leukemia (AML) patients resistant to conventional chemotherapies are limited and novel therapeutic agents are needed. IL3 receptor alpha (IL3Rα, or CD123) is expressed on the majority of AML blasts, and there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac8020bf88554cef4d7229c4d038ea4f
https://doi.org/10.1158/1535-7163.c.6537988.v1
https://doi.org/10.1158/1535-7163.c.6537988.v1
Autor:
Che-Leung Law, Dennis R. Benjamin, Robert P. Lyon, Nicole M. Okeley, Nicole D. Nicholas, Jocelyn R. Setter, Jamie B. Miyamoto, Xinqun Zhang, Mechthild Jonas, Kim K. Emmerton, Fu Li
Antibody-drug conjugates (ADC) comprise targeting antibodies armed with potent small-molecule payloads. ADCs demonstrate specific cell killing in clinic, but the basis of their antitumor activity is not fully understood. In this study, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e50fcc62ed39c8a6e72591ade0c7eb
https://doi.org/10.1158/0008-5472.c.6508011
https://doi.org/10.1158/0008-5472.c.6508011
Autor:
Che-Leung Law, Dennis R. Benjamin, Robert P. Lyon, Nicole M. Okeley, Nicole D. Nicholas, Jocelyn R. Setter, Jamie B. Miyamoto, Xinqun Zhang, Mechthild Jonas, Kim K. Emmerton, Fu Li
Figure legends for Supplemental Figures S1-S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596ec54a00dfb6e85adb2ad80c769078
https://doi.org/10.1158/0008-5472.22410507.v1
https://doi.org/10.1158/0008-5472.22410507.v1