Zobrazeno 1 - 10
of 314
pro vyhledávání: '"Dennis R. Roop"'
Autor:
Yosuke Ishitsuka, Tatsuya Ogawa, Yoshiyuki Nakamura, Noriko Kubota, Yasuhiro Fujisawa, Rei Watanabe, Naoko Okiyama, Manabu Fujimoto, Dennis R. Roop, Akemi Ishida-Yamamoto
Publikováno v:
JID Innovations, Vol 2, Iss 1, Pp 100065- (2022)
Cornification involves cytoskeletal cross-linkages in corneocytes (the brick) and the secretion of lipids/adhesion structures to the interstitial space (the mortar). Because the assembly of lipid envelopes precedes corneocyte maturation, loricrin is
Externí odkaz:
https://doaj.org/article/3f586b8bb46046aeb57214cd1957d59e
Autor:
Yosuke Ishitsuka, Dennis R. Roop
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 673 (2022)
Cornification is a specialized mode of the cell-death program exclusively allowed for terrestrial amniotes. Recent investigations suggest that loricrin (LOR) is an important cornification effector. As the connotation of its name (“lorica” meaning
Externí odkaz:
https://doaj.org/article/54a1efd7a81d431095cf22608d41b6b4
Autor:
Igor Kogut, Sandra M. McCarthy, Maryna Pavlova, David P. Astling, Xiaomi Chen, Ana Jakimenko, Kenneth L. Jones, Andrew Getahun, John C. Cambier, Anna M. G. Pasmooij, Marcel F. Jonkman, Dennis R. Roop, Ganna Bilousova
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Induced pluripotent stem cells (iPSCs) have potential for regenerative medicine applications, but are generated with very low efficiency. Here, the authors show highly efficient reprogramming of human primary fibroblasts to iPSCs via the synergistic
Externí odkaz:
https://doaj.org/article/279523f467794ff7bb0f3d426b9968a3
Autor:
Yosuke Ishitsuka, Dennis R. Roop
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 47 (2021)
A functional epithelial barrier necessitates protection against dehydration, and ichthyoses are caused by defects in maintaining the permeability barrier in the stratum corneum (SC), the uppermost protective layer composed of dead cells and secretory
Externí odkaz:
https://doaj.org/article/b8aa802b6e14421fb4c07b050761a16b
Autor:
Antonio Jimeno, Rene Gonzalez, Dennis R. Roop, William Robinson, Jing H. Wang, Xiao-Jing Wang, Theresa Medina, Hilary Somerset, Aik-Choon Tan, Dexiang Gao, Randi Yeager, Bettina Miller, Karina Gomez, Cera Nieto, Phuong N. Le, Loni Perrenoud, Julie Reisinger, Tugs-Saikhan Chimed, Stephen B. Keysar, Nathaniel Alzofon, J. Jason Morton
Resistance to immunotherapy is a significant challenge, and the scarcity of human models hinders the identification of the underlying mechanisms. To address this limitation, we constructed an autologous humanized mouse (aHM) model with hematopoietic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::655a6f1c1b66b2ca94647218902d75a6
https://doi.org/10.1158/1541-7786.c.6545108.v1
https://doi.org/10.1158/1541-7786.c.6545108.v1
Autor:
Antonio Jimeno, Rene Gonzalez, Dennis R. Roop, William Robinson, Jing H. Wang, Xiao-Jing Wang, Theresa Medina, Hilary Somerset, Aik-Choon Tan, Dexiang Gao, Randi Yeager, Bettina Miller, Karina Gomez, Cera Nieto, Phuong N. Le, Loni Perrenoud, Julie Reisinger, Tugs-Saikhan Chimed, Stephen B. Keysar, Nathaniel Alzofon, J. Jason Morton
Table S1. Expanded HSPC engraftment into mouse cohorts Table S2. Human immune cell presence in HM tissues Table S3a. CUHM003 mutations present at diagnosis b. Additional CUHM003 mutations present at progression c. CUHM005 mutations present at diagnos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c3fbcf5bdeea96081d6cb3e0e4b08c
https://doi.org/10.1158/1541-7786.22526474.v1
https://doi.org/10.1158/1541-7786.22526474.v1
Autor:
Dennis R. Roop, Subrata Sen, Carlos Caulin, William R. Brinkley, James Fitzpatrick, Hiroshi Katayama, Hong Sheng, Yiyun Chen, Enrique C. Torchia
Supplementary Data 1 from A Genetic Variant of Aurora Kinase A Promotes Genomic Instability Leading to Highly Malignant Skin Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ee8da2c99933ced10d13e79b4c9b1c
https://doi.org/10.1158/0008-5472.22378202.v1
https://doi.org/10.1158/0008-5472.22378202.v1
Autor:
Dennis R. Roop, Subrata Sen, Carlos Caulin, William R. Brinkley, James Fitzpatrick, Hiroshi Katayama, Hong Sheng, Yiyun Chen, Enrique C. Torchia
Supplementary Figure 1 from A Genetic Variant of Aurora Kinase A Promotes Genomic Instability Leading to Highly Malignant Skin Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5081f9df11ef3c6d8720673ff938cb20
https://doi.org/10.1158/0008-5472.22378199
https://doi.org/10.1158/0008-5472.22378199
Autor:
Dennis R. Roop, Subrata Sen, Carlos Caulin, William R. Brinkley, James Fitzpatrick, Hiroshi Katayama, Hong Sheng, Yiyun Chen, Enrique C. Torchia
Supplementary Figure 2 from A Genetic Variant of Aurora Kinase A Promotes Genomic Instability Leading to Highly Malignant Skin Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c3ea2ce580e4d879c970efb086d10c
https://doi.org/10.1158/0008-5472.22378196
https://doi.org/10.1158/0008-5472.22378196
Autor:
Matthias Schäfer, Ann‐Helen Willrodt, Svitlana Kurinna, Andrea S Link, Hany Farwanah, Alexandra Geusau, Florian Gruber, Olivier Sorg, Aaron J Huebner, Dennis R Roop, Konrad Sandhoff, Jean‐Hilaire Saurat, Erwin Tschachler, Marlon R Schneider, Lutz Langbein, Wilhelm Bloch, Hans‐Dietmar Beer, Sabine Werner
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 4, Pp 442-457 (2014)
Abstract The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacological Nrf2 activation is a promising strategy for skin protection and cancer prevention. We show here that prolonged Nrf2 activation in keratinoc
Externí odkaz:
https://doaj.org/article/8045fc2494be47d89d7a67ce26c7aaac