Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Dennis R Trune"'
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119228 (2015)
Transtympanic steroid treatment will induce changes in ion homeostasis and inflammatory gene expression to decrease middle ear inflammation due to bacterial inoculation.Otitis media is common, but treatment options are limited to systemic antibiotic
Externí odkaz:
https://doaj.org/article/ef14f74b21684107835be71565de9cc1
Autor:
Dennis R. Trune, Carol J. MacArthur, Fran Hausman, Dongseok Choi, Katherine D. Shives, J. Beth Kempton
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 128:134S-138S
Objectives: Glucocorticoids are given for sensorineural hearing loss, but little is known of their molecular impact on the inner ear. Furthermore, in spite of claims of improved hearing recovery with intratympanic delivery of steroids, no studies hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5d911e697492eaece070f17939626a
https://doi.org/10.1177/0003489419837562
https://doi.org/10.1177/0003489419837562
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75213 (2013)
Otitis media is known to alter expression of cytokine and other genes in the mouse middle ear and inner ear. However, whole mouse genome studies of gene expression in otitis media have not previously been undertaken. Ninety-nine percent of mouse gene
Externí odkaz:
https://doaj.org/article/e48f9c2749b34a7f8c6f320d8dc3d7b4
Publikováno v:
PLoS ONE, Vol 8, Iss 4 (2013)
Externí odkaz:
https://doaj.org/article/85d9d2f970254de2add37e9a76c5e60a
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39004 (2012)
The middle ear contains homeostatic mechanisms that control the movement of ions and fluids similar to those present in the inner ear, and are altered during inflammation.The normal middle ear cavity is fluid-free and air-filled to allow for effectiv
Externí odkaz:
https://doaj.org/article/82d10d201f4942f58bdc9d86ccfdece0
Publikováno v:
Hearing Research. 326:49-58
Although the inner ear has long been reported to be susceptible to middle ear disease, little is known of the inflammatory mechanisms that might cause permanent sensorineural hearing loss. Recent studies have shown inner ear tissues are capable of ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c184e2c7703b2cb991adba7fd3497d0
https://doi.org/10.1016/j.heares.2015.04.006
https://doi.org/10.1016/j.heares.2015.04.006
Publikováno v:
Otology & Neurotology. 36:1089-1095
The inner ear (IE) endothelium is capable of responding to therapeutic steroids by altering the local expression of cytokine and ion homeostasis genes that impact inflammation and fluid regulation.Glucocorticoids are often given transtympanically for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12db26c9c99682954b9a900df90298d0
https://doi.org/10.1097/mao.0000000000000725
https://doi.org/10.1097/mao.0000000000000725
Publikováno v:
Acta Oto-Laryngologica. 133:685-691
Age-related differences in the expression of inflammatory cytokines in the inner ear may contribute to the development of age-related hearing loss (ARHL).ARHL is characterized by tissue remodeling, ischemia, ion homeostasis, and inflammation. Steroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e29f41a5dee2fdefb63d95032f2265
https://doi.org/10.3109/00016489.2013.771407
https://doi.org/10.3109/00016489.2013.771407
Publikováno v:
International Forum of Allergy & Rhinology. 3:364-368
Background Chronic sinonasal inflammation is associated with tissue remodeling, such as osteitis, which may be a marker of refractory disease; however, the pathophysiology of osteitis in chronic rhinosinusitis (CRS) is insufficiently understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::911d45e4c8428eea58943598c5a55a9b
https://doi.org/10.1002/alr.21135
https://doi.org/10.1002/alr.21135
Autor:
Henry A. Milczuk, Philip B. Zald, Carol J. MacArthur, Zachary M. Soler, Sarah R. Carroll, Dennis R. Trune
Publikováno v:
International Journal of Pediatric Otorhinolaryngology. 76:976-979
Objective Toll-like receptors (TLR) activate the innate immune system. Single nucleotide polymorphisms (SNPs) in TLR genes are linked to increased susceptibility to infections. TLR4-deficient mice have increased incidence and duration of otitis media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a94464780b29dc855587669e9dcb32
https://doi.org/10.1016/j.ijporl.2012.03.011
https://doi.org/10.1016/j.ijporl.2012.03.011