Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Dennis R, Grayson"'
Autor:
Hooriyah S. Rizavi, Omar S. Khan, Hui Zhang, Runa Bhaumik, Dennis R. Grayson, Ghanshyam N. Pandey
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract A dysregulated hypothalamic-pituitary-adrenal (HPA) axis has repeatedly been demonstrated to play a fundamental role in psychiatric disorders and suicide, yet the mechanisms underlying this dysregulation are not clear. Decreased expression o
Externí odkaz:
https://doaj.org/article/1c4c58eb83d04267a50d23e25a747acf
Autor:
Wei-Yang Chen, Hu Chen, Kana Hamada, Eleonora Gatta, Ying Chen, Huaibo Zhang, Jenny Drnevich, Harish R. Krishnan, Mark Maienschein-Cline, Dennis R. Grayson, Subhash C. Pandey, Amy W. Lasek
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Alcohol use disorder (AUD) is highly comorbid with depression. Withdrawal from chronic alcohol drinking results in depression and understanding brain molecular mechanisms that drive withdrawal-related depression is important for finding new
Externí odkaz:
https://doaj.org/article/4f01af3adbe34d83bd69eca16d8ef2c2
Autor:
Henry Sershen, Alessandro Guidotti, James Auta, Jenny Drnevich, Dennis R. Grayson, Marin Veldic, Jordan Meyers, Mary Youseff, Adrian Zhubi, Keturah Faurot, Renrong Wu, Jingping Zhao, Hua Jin, Abel Lajtha, John M. Davis, Robert C. Smith
Publikováno v:
Biomarkers in Neuropsychiatry, Vol 5, Iss , Pp 100038- (2021)
Some of the biochemical abnormalities underlying schizophrenia, involve differences in methylation and methylating enzymes, as well as other related target genes. We present results of a study of differences in mRNA expression in peripheral blood lym
Externí odkaz:
https://doaj.org/article/0bbbabdd6f1d471e9a975af204f3de47
Autor:
Francesco, Matrisciano, Valentina, Locci, Erbo, Dong, Ferdinando, Nicoletti, Alessandro, Guidotti, Dennis R, Grayson
Publikováno v:
Current Neuropharmacology. 20:2354-2368
Background: mGlu5 metabotropic glutamate receptors are considered as candidate drug targets in the treatment of “monogenic” forms of autism spectrum disorders (ASD), such as Fragile- X syndrome (FXS). However, despite promising preclinical data,
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
REELN (RELN) is a large (420 kDa) glycoprotein that in adulthood is mostly synthesized in GABAergic neurons of corticolimbic structures. Upon secretion in the extracellular matrix, RELN binds to VLDL, APOE2, and 32 Integrin receptors located on
Externí odkaz:
https://doaj.org/article/aae5dcc5e2aa4f81ad50be7b75ffee70
Autor:
Harish R. Krishnan, Huaibo Zhang, Ying Chen, John Peyton Bohnsack, Annie W. Shieh, Handojo Kusumo, Jenny Drnevich, Chunyu Liu, Dennis R. Grayson, Mark Maienschein-Cline, Subhash C. Pandey
Publikováno v:
Molecular psychiatry. 27(11)
Positive effects of alcohol drinking such as anxiolysis and euphoria appear to be a crucial factor in the initiation and maintenance of alcohol use disorder (AUD). However, the mechanisms that lead from chromatin reorganization to transcriptomic chan
Autor:
Jenny Drnevich, James Auta, Harish R. Krishnan, Eleonora Gatta, Subhash C. Pandey, Erbo Dong, Dennis R. Grayson, Vikram Saudagar, Alessandro Guidotti, Ying Chen
Publikováno v:
Molecular psychiatry
Environmental factors, including substance abuse and stress, cause long-lasting changes in the regulation of gene expression in the brain via epigenetic mechanisms, such as DNA methylation. We examined genome-wide DNA methylation patterns in the pref
Autor:
Dennis R. Grayson
Publikováno v:
Genes, Vol 8, Iss 7, p 181 (2017)
In 1957, Conrad H. Waddington published a paper in which he demonstrated the inheritance of an acquired characteristic in a population in response to an environmental stimulus [1].[...]
Externí odkaz:
https://doaj.org/article/55cbf8112e444b16b9426c43e7323eb6
Publikováno v:
Molecular Pharmacology
Schizophrenia (SZ), schizoaffective (SZA), and bipolar (BP) disorder are neurodevelopmental psychopathological conditions related, in part, to genetic load and, in part, to environmentally induced epigenetic dysregulation of chromatin structure and f
Autor:
Erminio Costa, John Davis, Dennis R. Grayson, Alessandro Guidotti, George D. Pappas, Christine Pesold
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 5, Pp 723-742 (2001)
In this review, we will first present a brief overview of the current understanding of: (a) the biology of reelin; (b) the putative reelin signaling pathways via integrin receptor stimulation; (c) the cytosolic adapter protein DAB1, which appears to
Externí odkaz:
https://doaj.org/article/e174bd8ea8014b8faf7c7d0d37a0dd6a