Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dennis Paul Phillion"'
Autor:
Katherine Loomis, Kevin Daniel Freeman-Cook, Zhengrong Zhao, Susan Tapley, Dennis Paul Phillion, Richard L. Elliott, Steven B. Coffey, Christopher S. Jones, Kevin E. Henegar, Kirk McPherson, Chris Limberakis, Scott Bader, Janet A. Houser, Leanne M. Buzon, Angel Guzman-Perez, Shawn D. Doran, Wei Song, Betsy Pierce, Kendra Louise Nelson, Meihua Tu, William P. Esler, Kenneth J. DiRico, Sharad B. Murdande, Jeffrey W. Corbett, Paul A. Amor, Eliot Sugarman
Publikováno v:
Journal of medicinal chemistry. 55(2)
This paper describes the design and synthesis of a novel series of dual inhibitors of acetyl-CoA carboxylase 1 and 2 (ACC1 and ACC2). Key findings include the discovery of an initial lead that was modestly potent and subsequent medicinal chemistry op
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(10)
Focused SAR studies were carried out around 5-heteroaryl and 1-amide portions of the 2-chlorobenzamide scaffold, resulting in the discovery of a potent, metabolically stable and centrally penetrable antagonist against P2X 7 receptor.
Autor:
Darryl G. Cleary, Dennis Paul Phillion
Publikováno v:
The Journal of Organic Chemistry. 57:2763-2764
Publikováno v:
The Journal of Organic Chemistry. 45:1535-1538
Publikováno v:
The Journal of Organic Chemistry. 46:3209-3214
Publikováno v:
Tetrahedron Letters. 20:1469-1472
Macrolide formation from reactive crown ether 1 is driven by the proximate binding of alkoxide and thioester functionalities.
Publikováno v:
The Journal of Organic Chemistry. 46:3204-3208
Publikováno v:
The Journal of Organic Chemistry. 51:1610-1612