Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dennis P. Gately"'
Autor:
Stephen B. Howell, Tim Vorberg, Xiying Shang, Joji Watanabe, Clara Wong, Songman Yu, Arisa Watanabe, Songyu Tian, Wannan Chen, Dennis P. Gately, Maria Carmen Mulero
Publikováno v:
Bioconjugate chemistry. 32(2)
LGR5 and LGR6 mark epithelial stem cells in many niches including the ovarian surface and fallopian tube epithelia from which ovarian cancer arises. Human ovarian cancers express these receptors at high levels and express one of their ligands, RSPO1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975fd2f1667286df9165f0c0da6b495c
https://pubmed.ncbi.nlm.nih.gov/33492953
https://pubmed.ncbi.nlm.nih.gov/33492953
Publikováno v:
International Journal of Cancer. 91:555-562
The GADD153 gene is strongly transcriptionally activated by many types of cellular injury and the magnitude of the change in GADD153 expression is proportional to the extent of damage. We developed a novel reporter system in which a chimeric gene con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7862c30b2f02414da52bf20ef844f91c
https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1083>3.0.co
https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1083>3.0.co
Publikováno v:
British Journal of Cancer
The inability to assess the extent of tumour damage immediately following treatment is a major clinical obstacle to improving the management of cancer patients. Normally, the effectiveness of chemotherapy or radiation therapy cannot be determined for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42b32d4417decc67d0e219a06ca88fa
https://doi.org/10.1038/bjc.1994.455
https://doi.org/10.1038/bjc.1994.455
Autor:
Jeffrey A. Jones, Doreen K. Hom, Stephen B. Howell, Franz Thiebaut, Seiji Isonishi, Relef Kroning, Gerrit Los, R D Christen, A. Jekunen, Dennis P. Gately
Publikováno v:
Cancer and Metastasis Reviews. 13:175-189
Even though alterations in receptor and nonreceptor kinases are involved in the development of human cancer, many cancer cell lines still retain their responsiveness to growth factors. We have investigated the hypothesis that cellular signaling event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f457268e7bfa54052b70293fa7665efc
https://doi.org/10.1007/bf00689635
https://doi.org/10.1007/bf00689635
Autor:
Dennis P. Gately, Salman Kirmani, M M de las Alas, R D Christen, G Los, D E Weiner, Horacio B. D'Agostino, Edward F. McClay, Steven C. Plaxe, Stefan Aebi, D. Darrah, Benbatoul K, Stephen B. Howell
Publikováno v:
Cancer chemotherapy and pharmacology. 45(5)
Purpose: We investigated the relationship between the basal and treatment-induced change in the tumor expression of the drug resistance gene MDR1 and the cellular injury response gene GADD153, and clinical response to paclitaxel treatment. Methods: M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19691bee74a2770584bc2c6b4ba979ad
https://pubmed.ncbi.nlm.nih.gov/10803921
https://pubmed.ncbi.nlm.nih.gov/10803921
Autor:
Stephen B. Howell, Dennis P. Gately
Publikováno v:
The Journal of biological chemistry. 271(34)
The GADD153 promoter is transcriptionally activated by paclitaxel-induced injury. Promoter deletion from −786 to −85 base pairs relative to the start of transcription had no significant effect on activation, but deletion to the TATA box abolished
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba38b411f3abcbb0f229b9d8983b97d3
https://pubmed.ncbi.nlm.nih.gov/8702804
https://pubmed.ncbi.nlm.nih.gov/8702804
Publikováno v:
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2 ISBN: 9781489902207
Treatment of cells with clinically relevant exposures to cisplatin (DDP) activates an injury response that eventually induces death via an apoptotic mechanism. The activation of apoptosis involves generation of a signal from a detector that senses th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97035061eb71b1fbe093abbe57874eca
https://doi.org/10.1007/978-1-4899-0218-4_25
https://doi.org/10.1007/978-1-4899-0218-4_25
Autor:
Peter Naredi, Gerrit Los, Stephen B. Howell, Michael L. Costello, Dennis P. Gately, Franz Thiebaut
Publikováno v:
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2 ISBN: 9781489902207
Small molecules cross membranes by either passive diffusion or are transported actively by transmembrane proteins. If given enough time, however, essentially any molecule will diffuse across a lipid bilayer down its concentration gradient. The rate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::903cd95ec7558fb1d76efe0a4244a7ce
https://doi.org/10.1007/978-1-4899-0218-4_9
https://doi.org/10.1007/978-1-4899-0218-4_9
Publikováno v:
British journal of cancer, vol 73, iss 1
British Journal of Cancer
British Journal of Cancer
Signal transduction pathways activated by injury play a central role in coordinating the cellular responses that determine whether a cell survives or dies. GADD153 expression increases markedly in response to some types of cellular injury and the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aef7b0c461b8b52e4c90c8039b17eb6
https://escholarship.org/uc/item/40s783bf
https://escholarship.org/uc/item/40s783bf
Autor:
S. B. Howell, Dennis P. Gately
Publikováno v:
British Journal of Cancer
Acquired resistance to cisplatin (DDP) is a major clinical problem in the treatment of ovarian, testicular, and head and neck carcinomas; decreased accumulation of DDP is the most consistently observed alteration in resistant cells. It has been postu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cc3e6e02b18c0e38c451849365ab9d
https://pubmed.ncbi.nlm.nih.gov/8512802
https://pubmed.ncbi.nlm.nih.gov/8512802