Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines

Autor: Mandy B. Hulst, Le Zhang, Helga U. van der Heul, Chao Du, Somayah S. Elsayed, Arina Koroleva, Thadee Grocholski, Dennis P. A. Wander, Mikko Metsä-Ketelä, Jacques J. C. Neefjes, Gilles P. van Wezel

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

Introduction: Daunorubicin and doxorubicin, two anthracycline polyketides produced by S. peucetius, are potent anticancer agents that are widely used in chemotherapy, despite severe side effects. Recent advances have highlighted the potential of prod

Externí odkaz: https://doaj.org/article/4df9c2d97b6a46d0a40d7261af1249f7

Synthetic (N, N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs

Autor: Jeroen D. C. Codée, Branca C van Veen, Thomas Bruyning, Joey G C Vlaming, Dennis P A Wander, Thomas Hansen, Gijsbert A. van der Marel, Merijn B L Vriends, Jacques Neefjes, Sabina Y van der Zanden, Herman S. Overkleeft

Publikováno v: The Journal of Organic Chemistry
Wander, D P A, Van Der Zanden, S Y, Vriends, M B L, Van Veen, B C, Vlaming, J G C, Bruyning, T, Hansen, T, Van Der Marel, G A, Overkleeft, H S, Neefjes, J J C & Codée, J D C 2021, ' Synthetic (N, N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs ', The Journal of organic chemistry, vol. 86, no. 8, pp. 5757-5770 . https://doi.org/10.1021/acs.joc.1c00220
Journal of Organic Chemistry
Journal of Organic Chemistry, 86(8), 5757-5770. American Chemical Society ({ACS})
Journal of Organic Chemistry, 86(8), 5757-5770. AMER CHEMICAL SOC
The Journal of organic chemistry, 86(8), 5757-5770. American Chemical Society

Anthracyclines are effective drugs in the treatment of various cancers, but their use comes with severe side effects. The archetypal anthracycline drug, doxorubicin, displays two molecular modes of action: DNA double-strand break formation (through t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd22143011eab15341b55008619a42c
http://www.scopus.com/inward/record.url?scp=85104915338&partnerID=8YFLogxK

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin

Autor: Christine L. Mummery, Olaf van Tellingen, Hermen S. Overkleeft, Charlotte L. Zuur, Jacques Neefjes, Dennis P A Wander, Jeroen Bakker, Xiaohang Qiao, Tessa van Herwaarden, Elisa Giacomelli, Anke M. Smits, Baoxu Pang, Milena Bellin, Valeria V. Orlova, Jimmy J. Akkermans, Sophie Gerhardt, Linda Smit, J.-Y. Song, Sabina Y van der Zanden, Noortje van Gils, Ramon Arens, Junmin Li, Arjo Rutten, Daniel M. Borràs, Suzanne van Duikeren, Xiao Yang Li, Leon G.J. Tertoolen

Publikováno v: Qiao, X, van der Zanden, S Y, Wander, D P A, Borràs, D M, Song, J Y, Li, X, van Duikeren, S, van Gils, N, Rutten, A, van Herwaarden, T, van Tellingen, O, Giacomelli, E, Bellin, M, Orlova, V, Tertoolen, L G J, Gerhardt, S, Akkermans, J J, Bakker, J M, Zuur, C L, Pang, B, Smits, A M, Mummery, C L, Smit, L, Arens, R, Li, J, Overkleeft, H S & Neefjes, J 2020, ' Uncoupling DNA damage from chromatin damage to detoxify doxorubicin ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 26, pp. 15182-15192 . https://doi.org/10.1073/pnas.1922072117
Proceedings of the National Academy of Sciences, 117(26), 15182-15192. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 117(26), 15182-15192. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(26), 15182-15192
Proceedings of the National Academy of Sciences of the United States of America

Significance Anthracyclines like doxorubicin are anticancer drugs, used by over 1 million cancer patients annually. However, they cause severe side effects, most notably, cardiotoxicity and therapy-related malignancies. It is unclear whether these si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6082d1592787bfbc7ecf586f7775901c
https://research.vumc.nl/en/publications/6f402344-13ef-4a55-838d-a6a835f4e619

Synthesis of Carba-Cyclophellitols: a New Class of Carbohydrate Mimetics

Autor: Dennis P A Wander, Jeroen D. C. Codée, Herman S. Overkleeft, Johannes M. F. G. Aerts, Thomas J. M. Beenakker, Gijsbert A. van der Marel

Publikováno v: European Journal of Organic Chemistry

Cyclophellitol and cyclophellitol aziridine are potent and irreversible inhibitors of retaining β‐glucosidases. They preferentially adopt a 4H3 half‐chair conformation, thereby mimicking the substrate‐transition‐state conformation characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a4e3ac12150b1cf0962cd83101fe1d8
https://doi.org/10.1002/ejoc.201701601