Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Dennis O'rourke"'
Autor:
Danyi Wang, Dennis O’Rourke, Jorge F. Sanchez-Garcia, Ti Cai, Juergen Scheuenpflug, Zheng Feng
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background MutL Homolog 1 (MLH1) promotor methylation is associated with microsatellite instability high colorectal cancer (CRC). The strong correlation between methylation status and cancer development and progression has led to a growing i
Externí odkaz:
https://doaj.org/article/cdcef17b668c499fa74247605b92d156
Autor:
Danyi Wang PhD, P. Alexander Rolfe PhD, Dorothee Foernzler PhD, Dennis O’Rourke MS, Sheng Zhao PhD, Juergen Scheuenpflug PhD, Zheng Feng MD, PhD
Publikováno v:
Technology in Cancer Research & Treatment, Vol 21 (2022)
Objective: RNA extraction and library preparation from formalin-fixed, paraffin-embedded (FFPE) samples are crucial pre-analytical steps towards achieving optimal downstream RNA sequencing (RNASeq) results. In this study, we assessed 2 Illumina libra
Externí odkaz:
https://doaj.org/article/b42a0ab18a8c46abbbf7c08946d5fdd3
Autor:
Dennis O'Rourke, Danyi Wang, Jorge F Sanchez-Garcia, Maria Perella Cusano, Waldemar Miller, Ti Cai, Juergen Scheuenpflug, Zheng Feng
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250849 (2021)
Development of a clinically applicable liquid biopsy-based test for PD-L1 mRNA expression would be beneficial in providing complementary evidence to current immunohistochemistry assays. Hence, we report the development of a fit-for-purpose assay for
Externí odkaz:
https://doaj.org/article/5cb6fb0ac0a54dee8a6a076bc6158c73
Autor:
Lumila P. Menéndez, Kathleen S. Paul, Constanza de la Fuente, Tatiana Almeida, Miguel Delgado, Gonzalo Figueiro, Kelsey Jorgensen, Susan Kuzminsky, María Clara López‐Sosa, Johanna Nichols, Mirjana Roksandic, George Richard Scott, Dennis O'Rourke, Mark Hubbe
Publikováno v:
Evolutionary Anthropology: Issues, News, and Reviews. 31:62-68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13b39a4ef7dd9f10ec0d2ea9ee36ded1
https://doi.org/10.1002/evan.21937
https://doi.org/10.1002/evan.21937
Autor:
Ti Cai, Dennis O'Rourke, Danyi Wang, Juergen Scheuenpflug, Zheng Feng, Jorge F. Sanchez-Garcia
Publikováno v:
BMC Cancer
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
Background MutL Homolog 1 (MLH1) promotor methylation is associated with microsatellite instability high colorectal cancer (CRC). The strong correlation between methylation status and cancer development and progression has led to a growing interest i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506c6e17d9b2004bd9ce2fa99f5ef4d6
http://europepmc.org/articles/PMC8272385
http://europepmc.org/articles/PMC8272385
Autor:
Danyi Wang, Zheng Feng, Maria Perella Cusano, Juergen Scheuenpflug, Jorge F. Sanchez-Garcia, Dennis O’Rourke, Ti Cai, Waldemar Miller
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0250849 (2021)
PLoS ONE, Vol 16, Iss 5, p e0250849 (2021)
Development of a clinically applicable liquid biopsy-based test for PD-L1 mRNA expression would be beneficial in providing complementary evidence to current immunohistochemistry assays. Hence, we report the development of a fit-for-purpose assay for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29998713fe3e87bbe66920761df7bea
https://pubmed.ncbi.nlm.nih.gov/33970922
https://pubmed.ncbi.nlm.nih.gov/33970922
Publikováno v:
Cancer Research. 81:542-542
Introduction: Reliable detection of low mutant allele fractions (MAF) in circulating tumor DNA (ctDNA) offers clinically crucial information. Importantly, minimal residual disease (MRD) detection in solid tumors has been recognized as a powerful read
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50fd39941d174d7caf677e8629886340
https://doi.org/10.1158/1538-7445.am2021-542
https://doi.org/10.1158/1538-7445.am2021-542
Autor:
Ti Cai, Dennis O'Rourke, Zheng Feng, Jorge F. Sanchez-Garcia, Juergen Scheuenpflug, Danyi Wang
Publikováno v:
Cancer Research. 80:1976-1976
Purpose Studies have shown that MutL Homolog 1 (MLH1) promotor methylation is closely associated with microsatellite instability high colorectal cancer (CRC). The strong correlation between methylation status and cancer development and progression ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b981a07ac11b270a17a23bbaf52fbff7
https://doi.org/10.1158/1538-7445.am2020-1976
https://doi.org/10.1158/1538-7445.am2020-1976
Publikováno v:
Cancer Research. 80:5881-5881
Purpose High analytical sensitivity and a broad dynamic range make RNA sequencing (RNA-Seq) an appealing platform for mRNA expression analyses for clinical exploratory biomarker development and identification. However, the reliability and accuracy of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d9a10cbf2dd62de1aa75e27ebc437d
https://doi.org/10.1158/1538-7445.am2020-5881
https://doi.org/10.1158/1538-7445.am2020-5881
Autor:
Danyi Wang, Juergen Scheuenpflug, P. Alexander Rolfe, Zheng Feng, Dennis O'Rourke, Jorge F. Sanchez-Garcia, Alice Huang
Publikováno v:
Cancer Research. 80:2016-2016
Purpose HTG EdgeSeq Next Generation Sequencing (NGS) technology is a targeted RNA Sequencing (RNA-Seq) platform based on quantitative nuclease protection chemistry, which requires substantially less sample input than RNA-Seq (one formalin-fixed paraf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b38c182c1a307a9e1d18b993f8f6894
https://doi.org/10.1158/1538-7445.am2020-2016
https://doi.org/10.1158/1538-7445.am2020-2016