Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Dennis Madsen"'
Autor:
Olga Kubrak, Anne F. Jørgensen, Takashi Koyama, Mette Lassen, Stanislav Nagy, Jacob Hald, Gianluca Mazzoni, Dennis Madsen, Jacob B. Hansen, Martin Røssel Larsen, Michael J. Texada, Jakob L. Hansen, Kenneth V. Halberg, Kim Rewitz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Obesity impairs tissue insulin sensitivity and signaling, promoting type-2 diabetes. Although improving insulin signaling is key to reversing diabetes, the multi-organ mechanisms regulating this process are poorly defined. Here, we screen th
Externí odkaz:
https://doaj.org/article/c0b57de7e927476fa4302bfb4b15a306
Autor:
Lena K Hansson, Rasmus Borup Hansen, Sune Pletscher-Frankild, Rudolfs Berzins, Daniel Hvidberg Hansen, Dennis Madsen, Sten B Christensen, Malene Revsbech Christiansen, Ulrika Boulund, Xenia Asbæk Wolf, Sonny Kim Kjærulff, Martijn van de Bunt, Søren Tulin, Thomas Skøt Jensen, Rasmus Wernersson, Jan Nygaard Jensen
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233956 (2020)
BackgroundSurveying the scientific literature is an important part of early drug discovery; and with the ever-increasing amount of biomedical publications it is imperative to focus on the most interesting articles. Here we present a project that high
Externí odkaz:
https://doaj.org/article/97287a9d68b2414aad61ea290a973c33
Autor:
Violeta Georgieva Tsonkova, Fredrik Wolfhagen Sand, Xenia Asbæk Wolf, Lars Groth Grunnet, Anna Kirstine Ringgaard, Camilla Ingvorsen, Louise Winkel, Mark Kalisz, Kevin Dalgaard, Christine Bruun, Johannes Josef Fels, Charlotte Helgstrand, Sven Hastrup, Fredrik Kryh Öberg, Erik Vernet, Michael Paolo Bastner Sandrini, Allan Christian Shaw, Carsten Jessen, Mads Grønborg, Jacob Hald, Hanni Willenbrock, Dennis Madsen, Rasmus Wernersson, Lena Hansson, Jan Nygaard Jensen, Annette Plesner, Tomas Alanentalo, Maja Borup Kjær Petersen, Anne Grapin-Botton, Christian Honoré, Jonas Ahnfelt-Rønne, Jacob Hecksher-Sørensen, Philippe Ravassard, Ole D. Madsen, Claude Rescan, Thomas Frogne
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 144-157 (2018)
Objective: To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a scree
Externí odkaz:
https://doaj.org/article/87dc16429b2843beab1b7a3a86b28d77
Autor:
Felix Teufel, Jan C. Refsgaard, Marina A. Kasimova, Kristine Deibler, Christian T. Madsen, Carsten Stahlhut, Mads Grønborg, Ole Winther, Dennis Madsen
Publikováno v:
Journal of Chemical Information and Modeling. 63:2651-2655
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca1d45353fbaef4cba2107ff3acc745
https://doi.org/10.1021/acs.jcim.3c00378
https://doi.org/10.1021/acs.jcim.3c00378
Autor:
Felix Teufel, Jan C. Refsgaard, Marina A. Kasimova, Christian T. Madsen, Carsten Stahlhut, Mads Grønborg, Ole Winther, Dennis Madsen
Many secreted endogenous peptides rely on signalling pathways to exert their function in the body. While peptides can be discovered through high throughput technologies, their cognate receptors typically cannot, hindering the understanding of their m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b4df7af4fcd572d7cbbb3f79237844
https://doi.org/10.1101/2022.10.28.514036
https://doi.org/10.1101/2022.10.28.514036
Sequential Gaussian Process Regression for Simultaneous Pathology Detection and Shape Reconstruction
Publikováno v:
Medical Image Computing and Computer Assisted Intervention – MICCAI 2021 ISBN: 9783030872397
MICCAI (5)
MICCAI (5)
In this paper, we view pathology segmentation as an outlier detection task. Hence no prior on pathology characteristics is needed, and we can rely solely on a statistical prior on healthy data. Our method is based on the predictive posterior distribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f61cca7205c8c5becb3e66066da8687
https://doi.org/10.1007/978-3-030-87240-3_41
https://doi.org/10.1007/978-3-030-87240-3_41
Publikováno v:
Shape in Medical Imaging ISBN: 9783030610555
ShapeMI@MICCAI
ShapeMI@MICCAI
Point Distribution Models (PDM) require a dataset in which point-to-point correspondence between the individual shapes has been established. However, in the medical domain, minimising radiation exposure and pathological deformations are reasons why h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc7234727517b47e6b1af197b3c653cb
https://doi.org/10.1007/978-3-030-61056-2_3
https://doi.org/10.1007/978-3-030-61056-2_3
Autor:
Marcel Lüthi, Patrick Kahr, Thomas Vetter, Andreas Morel-Forster, Dana Rahbani, Dennis Madsen
Publikováno v:
Computer Vision – ECCV 2020 ISBN: 9783030585198
ECCV (17)
ECCV (17)
We propose to view non-rigid surface registration as a probabilistic inference problem. Given a target surface, we estimate the posterior distribution of surface registrations. We demonstrate how the posterior distribution can be used to build shape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6ffe5ccc2cfc01c3f51b6851378d51d
https://doi.org/10.1007/978-3-030-58520-4_17
https://doi.org/10.1007/978-3-030-58520-4_17
Autor:
Zhishuang Guan, Jinjing Xu, Dongxia Hao, Henrik Østergaard, Wei Yang, Lin Wang, Zhuoxiao Cao, Chih-Chuan Chang, Hong Cheng, Zibing Liu, Haibin Chen, Liu Wei, Chenxi Shen, Bing Shan, Fengting Xu, Di Liu, Bingke Yu, Wan Wang, Lujia Peng, Xun Li, Haisun Zhu, Jishu Wang, Haimei Xing, Zhiru Yang, Li Yang, Lin Li, Tengkun Li, Jing Su, Tzu-Yuan Chao, Zhe Sun, Yanping Du, Dapeng Li, Søren Berg Padkjær, Lishan Kang, Dennis Madsen, Esper Boel
Publikováno v:
Journal of Biotechnology. 260:18-30
Interactions between protein ligands and receptors play crucial roles in cell-cell signalling. Most of the human cell surface receptors have been identified in the post-Human Genome Project era but many of their corresponding ligands remain unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7b626364d5cbd96410e49c5fbee618
https://doi.org/10.1016/j.jbiotec.2017.08.023
https://doi.org/10.1016/j.jbiotec.2017.08.023
Autor:
Per Nørgaard, Jing Su, Jane Boesen Frantzen, Zhiru Yang, Anne Bugge, Chih-Chuan Chang, Linu M. John, Anna Secher, Zhenhua He, Haisun Zhu, Tao Huang, Wei Yang, Kristian Tage Hansen, Xiaoai Wu, Xiang Gao, Sarah J Paulsen, Sebastian Beck Jørgensen, Jacob Jeppesen, Zhe Sun, Linda Yang, Haibin Chen, Bing Shan, Xun Li, Karin Hultman, Jishu Wang, Søren Berg Padkjær, Dennis Madsen
Publikováno v:
Nature Medicine. 23:1158-1166
Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown. Here we show that GD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df7309da29b5ef10acefc642a3c77d83
https://doi.org/10.1038/nm.4394
https://doi.org/10.1038/nm.4394