Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Dennis M. Zimmerman"'
Autor:
Darryle D. Schoepp, Stephen L. Nutt, Wosnick Michael A, B. Korczak, Vikarna Rampersad, Rajender Kamboj, Rebecca A. True, Dennis M. Zimmerman, Shekter Lee
Publikováno v:
Journal of Neurochemistry. 62:1-9
Kainate is a potent neuroexcitatory agent; its neurotoxicity is thought to be mediated by an ionotropic receptor with a nanomolar affinity for kainate. In this report, we describe the cloning of a cDNA encoding a human glutamate ionotropic receptor s
Autor:
Ana Maria Escribano, Ana M. Castaño, E. Dominguez, Hamideh Zarrinmayeh, Dennis M. Zimmerman, Ken H. Ho, William Joseph Hornback, Eric S. Nisenbaum, Alma Jiménez, Nancy Rankl, Eric George Tromiczak, Carmen Dominguez Fernandez
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5203-5206
The synthesis and structure-activity relationship (SAR) of novel and highly potent positive allosteric modulators of AMPA receptors, 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, are described. These studies indicated that hi
Autor:
Mary Gates, Michael J. O'Neill, Katherine Whalley, David Bleakman, David M. Lodge, Jim Vandergriff, Dennis M. Zimmerman, Phil Skolnick, Mark A Ward, Tracey K. Murray, Eric S. Nisenbaum, Edward R. Siuda, Polly Baumbarger, Caroline A Hicks, Christine S. Robinson, Ann Marie L. Ogden
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:752-762
Glutamate is the major excitatory transmitter in the brain. Recent developments in the molecular biology and pharmacology of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) subtype of glutamate receptors have led to the discovery of
Autor:
Dennis M. Zimmerman, Miles Goodman Siegel, Gary A. Koppel, David C. Hunden, Patric James Hahn, Michael P. Clay, Robert F. Bruns, Anne M. Van Abbema, Donald R. Gehlert, Paul L. Ornstein, Douglas W. Johnson, Hamideh Zarrinmayeh, Douglas A. Schober, Michael O. Chaney, Buddy E. Cantrell
Publikováno v:
Tetrahedron. 55:11619-11639
This study describes the integrated application of parallel synthesis and computational chemistry to the design of potent nonpeptide antagonists for the neuropeptide Y-1 (NPY1) receptor. A lead molecule was modeled in the active site of the NPY1 rece
Autor:
James B. Thomas, Richard B. Rothman, Dennis M. Zimmerman, John S. Partilla, Kenner C. Rice, F. Ivy Carrol
Publikováno v:
Analgesia. 4:27-32
Autor:
S. Wayne Mascarella, Kenneth M. Gigstad, Jason P. Burgess, Buddy E. Cantrell, Scott E. Fix, James B. Thomas, Julie B. Cooper, F. Ivy Carroll, Dennis M. Zimmerman
Publikováno v:
Tetrahedron Letters. 40:403-406
A convergent, highly stereoselective synthetic approach to N-alkyl-4β-methyl-5-phenylmorphans has been developed utilizing alkylation of the metalloenamine of N-alkyl-1,2,3,6-tetrahydro-4-phenylpyridines with 2-(chloromethyl)-3,5-dioxahex-1-ene (Oka
Autor:
Jason P. Burgess, Xiaoling Zheng, Buddy E. Cantrell, Dennis M. Zimmerman, F. Ivy Carroll, Scott E. Fix, Lawrence E. Brieaddy, James B. Thomas, S. Wayne Mascarella
Publikováno v:
Tetrahedron Letters. 39:7001-7004
A convergent synthetic approach to 9β-methyl-2-alkyl-7-oxo-5-arylmorphans has been developed utilizing alkylation of the metalloenamine of 1,2,3,6-tetrahydro-4-aryl-1-alkylpyridines with 2-(chloromethyl)-3,5-dioxahex-1-ene (Okahara's reagent).
Autor:
Dennis M. Zimmerman, Joseph P. Tizzano, Rajender K. Kamboj, Louise N. Farrell, Ken H. Hoo, David Bleakman, James A. Monn, Buddy E. Cantrell, Ian A. Pullar
Publikováno v:
Journal of Medicinal Chemistry. 39:3617-3624
The synthesis and pharmacological characterization of a novel series of 4-aryl-substituted kainic acid analogs are described. Receptor affinities were determined on recombinantly expressed humGluR6 kainate receptors and on [3H]kainate binding to rat
Autor:
Darryle Darwin Schoepp, Buddy E. Cantrell, J. S. Gidda, Dennis M. Zimmerman, J. D. Leander, B G Johnson
Publikováno v:
Journal of Medicinal Chemistry. 37:2262-2265
Structure-activity relationship studies were pursued within N-substituted-trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines in an effort to discover a peripherally selective opioid antagonist with high activity following systemic administration. Alte
Autor:
Richard B. Rothman, Kenner C. Rice, Andrew Kim, Dennis M. Zimmerman, Heng Xu, George U. Char, Brian R. de Costa
Publikováno v:
Peptides. 14:17-20
Certain opioid antagonists of the phenylpiperidine series (PPAs), such as LY255582, seem uniquely efficacious at producing weight loss in lean and meal-fed obese Zucker rats. Comparison of the pharmacological and receptor binding profile of PPAs that