Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Dennis M Zaller"'
Autor:
Cristina St Pierre, Jane Guo, John D Shin, Laura W Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J Michael Ellis, Hani Houshyar, Michael A Crackower, Melanie A Kleinschek, Dallas C Jones, Alexandra Hicks, Dennis M Zaller, Stephen E Alves, Ravisankar A Ramadas
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180870 (2017)
While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune
Externí odkaz:
https://doaj.org/article/a511e5553a1e4c19982a055d21745012
Autor:
Fatemeh Moadab, Sepideh Sohrabi, Xiaoxing Wang, Rayan Najjar, Justina C. Wolters, Hua Jiang, Wenyan Miao, Donna Romero, Dennis M. Zaller, Megan Tran, Alison Bays, Martin S. Taylor, Rosana Kapeller, John LaCava, Tomas Mustelin
Publikováno v:
Mobile DNA, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with an unpredictable course of recurrent exacerbations alternating with more stable disease. SLE is characterized by broad immune activation and autoantibodies ag
Externí odkaz:
https://doaj.org/article/fe6226e258ca424d9883469888357136
Autor:
Peter J Stivers, Lauren Harmonay, Alexandra Hicks, Huseyin Mehmet, Melody Morris, Gain M Robinson, Peter R Strack, Mary J Savage, Dennis M Zaller, Izabela Zwierzynski, Philip E Brandish
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145151 (2015)
Glucocorticoid signaling regulates target genes by multiple mechanisms, including the repression of transcriptional activities of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) though direct protein-protein interactions and subs
Externí odkaz:
https://doaj.org/article/38e20953737e4617ae4904e635032021
Autor:
Alexander Solovyov, Julie M. Behr, David Hoyos, Eric Banks, Alexander W. Drong, Jimmy Z. Zhong, Enrique Garcia-Rivera, Wilson McKerrow, Chong Chu, Dennis M. Zaller, Menachem Fromer, Benjamin D. Greenbaum
Somatic activity of LINE-1 (L1) mobile elements has been implicated in cancer etiology, which may be related to the loss of p53-mediated regulation as a result ofTP53mutations. Quantifying the mechanisms of L1 regulation in cancer has been challengin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b9b6eab935d5f6a353477786727d0d6
https://doi.org/10.1101/2023.05.11.539471
https://doi.org/10.1101/2023.05.11.539471
Autor:
Laura Engstrom, Kyle J. Piers, Kenneth Jay Barr, Renu Jain, Dallas C. Jones, Huseyin Mehmet, Heidi Ferguson, Gary D. Glick, John S. Mudgett, Richard Miller, Xiao Hu, Hongjun Zhang, I-Ming Wang, Abbas Hawwari, Craig C. Correll, Barbara Joyce-Shaikh, Razvan Cristescu, Yanxia Guo, Daniel J. Cua, Gretchen A. Baltus, Yi Chen, Thomas Daniel Aicher, Dennis M. Zaller, Laura L. Carter, Laxminarayan G Hegde, Kenzie D. MacIsaac
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3206-3218 (2016)
Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+
Autor:
Stephen E. Alves, Michael A. Crackower, Philip R Cooper, Alan B. Northrup, Dennis M. Zaller, Erich E Sirkowski, Gretchen A. Baltus, Cynthia J. Koziol-White, Steven L. Smock, Blanca E. Himes, Reynold A. Panettieri, Yanlin Jia
Publikováno v:
British Journal of Pharmacology. 173:3080-3087
Background and purpose Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyper-reactivity (AHR). Spleen tyrosine kinase (Syk) mediates allergen-induced mast cell degranulation, a central component of a
Autor:
Teja Celhar, Hao Kim Lu, Lia Benso, Larissa Rakhilina, Hui Yin Lee, Shubhita Tripathi, Olga Zharkova, Wei Yee Ong, Hiroko Yasuga, Bijin Au, Damien Marlier, Lina Hsiu Kim Lim, Thomas Paulraj Thamboo, John S. Mudgett, Matthew F. Mackey, Dennis M. Zaller, John E. Connolly, Anna-Marie Fairhurst
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
The global increase in autoimmunity, together with the emerging autoimmune-related side effects of cancer immunotherapy, have furthered a need for understanding of immune tolerance and activation. Systemic lupus erythematosus (SLE) is the archetypica
Autor:
Changyou Zhou, David Sutton, Hong Li, Shaoqiang Huang, Xianghong Huo, Hilary A. Wilkinson, Haisheng Wang, Lusong Luo, Dennis M. Zaller, Hank Wang, Gui-Bai Liang, Wei Tang, Peter T. Meinke, Xuelin Yang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4077-4080
In a search for novel small molecule calcium-sensing receptor (CaSR) antagonists as oral bone anabolic agents, we discovered dihydrobenzofuran cyclopropane carboxylic acid derivatives, such as 12f (IC50=27.6nM), are highly potent calcium-sensing rece
Autor:
Juhi Firdos, Kern Jeffrey, Dennis M. Zaller, Douglas Hodges, Laurence Fayadat-Dilman, Isabel Figueroa, Shuli Zhang, Anthony Manibusan, Peter Stivers, Lily Y. Moy, Hyun Chong Woo, Yiwei Zhang, Nickolas Knudsen, Philip E. Brandish, Laura Garvin-Queen, Svetlana Antonenko, Kristen Kwasnjuk, Daniela M. Tomazela, Prasanthi Geda, SuChun Hseih, Mark T. Cancilla, Sanjiv J. Shah, Robert M. Garbaccio, Maribel Beaumont, John H. Shin, Lia Benso, Dennis Gately, Huiping Ma, Christopher Haines, Mangeng Cheng, Paul L. Miller, Mark Zielstorff, Linda Liang, Anthony Palmieri, Ying Sun, Guo Feng, Yujie Qu
Publikováno v:
Bioconjugate chemistry. 29(7)
Glucocorticoids (GCs) are excellent anti-inflammatory drugs but are dose-limited by on-target toxicity. We sought to solve this problem by delivering GCs to immune cells with antibody-drug conjugates (ADCs) using antibodies containing site-specific i
Autor:
Paul Bowness, Terri McClanahan, J. Richard Miller, Benjamin Kendrick, Kenneth Jay Barr, Roger Gundle, Peter C. Taylor, Michael Huhn, Hussein Al-Mossawi, Dennis M. Zaller, Rodney W. Morgan, Fiona Powrie, Craig C. Correll, K Doig, Erin Murphy, Hongjun Zhang, Jelle de Wit, Gary D. Glick, Thomas Daniel Aicher, Xiao Hu, Carolina V. Arancibia-Cárcamo
Increased frequencies of T-helper cells producing the proinflammatory cytokine IL-17A (TH17) have been reported in ankylosing spondylitis (AS), rheumatoid arthritis (RA), psoriatic arthritis (PsA), and inflammatory bowel disease (IBD).1 Genome-wide a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a049cacceddf0727c59017d25015692
https://doi.org/10.1016/j.jaci.2015.09.048
https://doi.org/10.1016/j.jaci.2015.09.048