Zobrazeno 1 - 10
of 348
pro vyhledávání: '"Dennis M Klinman"'
Autor:
Julia Scheiermann, Dennis M Klinman
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180561 (2017)
Bacteria can rarely be isolated from normal healthy lungs using conventional culture techniques, supporting the traditional belief that the lungs are sterile. Yet recent studies using next generation sequencing report that bacterial DNA commonly foun
Externí odkaz:
https://doaj.org/article/e915399c2c6944b4a8f46b4819d27a8b
Autor:
Wambui S Wandu, Cuiyan Tan, Osato Ogbeifun, Barbara P Vistica, Guangpu Shi, Samuel J H Hinshaw, Chengsong Xie, Xi Chen, Dennis M Klinman, Huaibin Cai, Igal Gery
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128906 (2015)
Mutations in LRRK2 are related to certain forms of Parkinson's disease and, possibly, to the pathogenesis of Crohn's disease. In both these diseases inflammatory processes participate in the pathogenic process. LRRK2 is expressed in lymphoid cells an
Externí odkaz:
https://doaj.org/article/d5759c03978d4c24a5912486766dcee2
Autor:
Jing Zhao, Yongshan Mou, Joshua D Bernstock, Dace Klimanis, Sixian Wang, Maria Spatz, Dragan Maric, Kory Johnson, Dennis M Klinman, Xiaohong Li, Xinhui Li, John M Hallenbeck
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140772 (2015)
The immune system plays a fundamental role in both the development and pathobiology of stroke. Inflammasomes are multiprotein complexes that have come to be recognized as critical players in the inflammation that ultimately contributes to stroke seve
Externí odkaz:
https://doaj.org/article/16f8c7ebefb54f14829b8023b01b19d6
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67991 (2013)
Synthetic oligonucleotides containing repetitive TTAGGG motifs mimic the immunosuppressive activity of telomeric DNA. These suppressive oligonucleotides (Sup ODN) are effective in the treatment/prevention of various inflammatory and autoimmune diseas
Externí odkaz:
https://doaj.org/article/7b5b1ba6c4d84c06b6c1a8f7e418e7d5
Autor:
Masaru Shimada, Shinya Abe, Toru Takahashi, Kazumasa Shiozaki, Mitsue Okuda, Hiroaki Mizukami, Dennis M Klinman, Keiya Ozawa, Kenji Okuda
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57606 (2013)
We previously reported on a monoclonal antibody (mAb) that targeted amyloid beta (Aß) protein. Repeated injection of that mAb reduced the accumulation of Aß protein in the brain of human Aß transgenic mice (Tg2576). In the present study, cDNA enco
Externí odkaz:
https://doaj.org/article/bb5584f2f78548e1b4006193324b91db
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 553-565 (2023)
Homeostatic restoration of an inflammatory response requires quenching of the immune system after pathogen threats vanish. A continued assault orchestrated by host defense results in tissue destruction or autoimmunity. A151 is the epitome of syntheti
Externí odkaz:
https://doaj.org/article/b69edf08eb7d40f583c41e62c6e26e45
Publikováno v:
Journal of Immunotherapy. 46:170-177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c70afcbb355b85e247925f2eb5ac57f
https://doi.org/10.1097/cji.0000000000000467
https://doi.org/10.1097/cji.0000000000000467
Publikováno v:
Blood Advances, Vol 1, Iss 26, Pp 2510-2519 (2017)
Abstract: Human monocytes differentiate into either proinflammatory or immunosuppressive macrophages in response to distinct stimuli. Results show that the Toll-like receptor 2/1 agonist PAM3 replicates the ability of macrophage colony-stimulating fa
Externí odkaz:
https://doaj.org/article/25ace06bbf3041ff8bfa25716e2f4542
Autor:
Guizhi Zhu, Geoffrey M. Lynn, Orit Jacobson, Kai Chen, Yi Liu, Huimin Zhang, Ying Ma, Fuwu Zhang, Rui Tian, Qianqian Ni, Siyuan Cheng, Zhantong Wang, Nan Lu, Bryant C. Yung, Zhe Wang, Lixin Lang, Xiao Fu, Albert Jin, Ido D. Weiss, Harshad Vishwasrao, Gang Niu, Hari Shroff, Dennis M. Klinman, Robert A. Seder, Xiaoyuan Chen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Albumin conjugates can enhance drug delivery. Here, the authors repurpose albumin-binding Evans blue to develop nanovaccines that co-deliver adjuvants and tumor neoantigens to antigen-presenting cells in lymph nodes, resulting in potent and durable a
Externí odkaz:
https://doaj.org/article/6c1cbd8acb2f42149db4a8201852deb6
Autor:
Chikashi Ishioka, Masato Kubo, Hiroyasu Ito, Shuku-ei Ito, Dennis M. Klinman, Hidekazu Shirota
Supplementary Figure 1. Increased IL-4 and IL-21 expression in tumor draining LNs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f31794a73c4c683c7dcc6131efda8d
https://doi.org/10.1158/2326-6066.22537249.v1
https://doi.org/10.1158/2326-6066.22537249.v1
